8.3 Tumors

Der erste Bericht über eine Antitumoraktiviträt von Extrakten von Boswellia serrata stammt von Jing und Mitarbeitern (1992) unter Verwendung von menschlichen HL 60 Leukämiezellen.

Untersuchungen, die 1999 in Tübingen durchgeführt wurden, zeigten ebenfalls eine Antitumorwirkung bei HL 60 Leukämiezellen sowie bei Glioblastomzellen. Es stellte sich jedoch bei all diesen Untersuchungen heraus, dass die in vitro verwendeten Konzentrationen von Boswelliaextrakten und Boswelliasäuren, die zur Hemmung des Tumorwachstums notwendig waren, wesentlich höher lagen als diejenigen, die eine Hemmung der Leukotriensynthese in Leukozyten bewirkten, wie dies auch aus der Tabelle hervorgeht. Andererseits ist es jedoch denkbar, dass niedrigere Konzentrationen von Boswelliasäuren bei solchen Tumoren wirksam sein könnten, die eng mit einer erhöhten Bildung von Leukotrien verbunden sind.

Hier einige Daten aus dem Tübinger Institut:

hl60.jpg

Publications

1.

New derivatives of 11-keto-β-boswellic acid (KBA) induce apoptosis in breast and prostate cancers cells.
Bini Araba A, Ur Rehman N, Al-Araimi A, Al-Hashmi S, Al-Shidhani S, Csuk R, Hussain H, Al-Harrasi A, Zadjali F

Nat Prod Res. 2019 Apr;():1-10.
PMID: 30931626 [PubMed - as supplied by publisher]

2.

Boswellic acid has anti-inflammatory effects and enhances the anticancer activities of Temozolomide and Afatinib, an irreversible ErbB family blocker, in human glioblastoma cells.
Barbarisi M, Barbarisi A, De Sena G, Armenia E, Aurilio C, Libutti M, Iaffaioli RV, Botti G, Maurea N, Quagliariello V

Phytother Res. 2019 Mar;():.
PMID: 30924205 [PubMed - as supplied by publisher]

3.

Interplay of non-coding RNAs and approved antimetabolites such as gemcitabine and pemetrexed in mesothelioma.
Biersack B

Noncoding RNA Res. 2018 Dec;3(4):213-225.
PMID: 30809600 [PubMed - as supplied by publisher]

4.

Relations between approved platinum drugs and non-coding RNAs in mesothelioma.
Biersack B

Noncoding RNA Res. 2018 Dec;3(4):161-173.
PMID: 30809599 [PubMed - as supplied by publisher]

5.

Synthesis of new boswellic acid derivatives as potential antiproliferative agents.
Shamraiz U, Hussain H, Ur Rehman N, Al-Shidhani S, Saeed A, Khan HY, Khan A, Fischer L, Csuk R, Badshah A, Al-Rawahi A, Hussain J, Al-Harrasi A

Nat Prod Res. 2019 Jan;():1-8.
PMID: 30691289 [PubMed - as supplied by publisher]

6.

Boswellia frereana suppresses HGF-mediated breast cancer cell invasion and migration through inhibition of c-Met signalling.
Parr C, Ali AY

J Transl Med. 2018 10;16(1):281.
PMID: 30314527 [PubMed - as supplied by publisher]

7.

Retraction: Boswellic Acid Blocks Signal Transducers and Activators of Transcription 3 Signaling, Proliferation, and Survival of Multiple Myeloma via the Protein Tyrosine Phosphatase SHP-1.

Mol Cancer Res. 2018 09;16(9):1444.
PMID: 30181208 [PubMed - as supplied by publisher]

8.

Acetyl-11-keto-β-boswellic acid suppresses docetaxel-resistant prostate cancer cells in vitro and in vivo by blocking Akt and Stat3 signaling, thus suppressing chemoresistant stem cell-like properties.
Liu YQ, Wang SK, Xu QQ, Yuan HQ, Guo YX, Wang Q, Kong F, Lin ZM, Sun DQ, Wang RM, Lou HX

Acta Pharmacol Sin. 2019 May;40(5):689-698.
PMID: 30171201 [PubMed - as supplied by publisher]

9.

Design, synthesis and biological evaluation of ring A modified 11-keto-boswellic acid derivatives as Pin1 inhibitors with remarkable anti-prostate cancer activity.
Huang M, Li A, Zhao F, Xie X, Li K, Jing Y, Liu D, Zhao L

Bioorg Med Chem Lett. 2018 10;28(19):3187-3193.
PMID: 30153964 [PubMed - as supplied by publisher]

10.

Review of Common Alternative Herbal "Remedies" for Skin Cancer.
Li JY, Kampp JT

Dermatol Surg. 2019 01;45(1):58-67.
PMID: 30096105 [PubMed - indexed for MEDLINE]

11.

Chemoprevention of inflammation-related colorectal cancer by silymarin-, acetyl-11-keto-beta-boswellic acid-, curcumin- and maltodextrin-enriched dietetic formulation in animal model.
Girardi B, Principi M, Pricci M, Giorgio F, Iannone A, Losurdo G, Ierardi E, Di Leo A, Barone M

Carcinogenesis. 2018 10;39(10):1274-1282.
PMID: 30084990 [PubMed - indexed for MEDLINE]

12.

3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.
Li W, Liu J, Fu W, Zheng X, Ren L, Liu S, Wang J, Ji T, Du G

J Exp Clin Cancer Res. 2018 Jul;37(1):132.
PMID: 29970196 [PubMed - indexed for MEDLINE]

13.

Combined acetyl-11-keto-β-boswellic acid and radiation treatment inhibited glioblastoma tumor cells.
Conti S, Vexler A, Edry-Botzer L, Kalich-Philosoph L, Corn BW, Shtraus N, Meir Y, Hagoel L, Shtabsky A, Marmor S, Earon G, Lev-Ari S

PLoS One. 2018;13(7):e0198627.
PMID: 29969452 [PubMed - indexed for MEDLINE]

14.

Homopiperazine-rhodamine B adducts of triterpenoic acids are strong mitocans.
Wolfram RK, Fischer L, Kluge R, Ströhl D, Al-Harrasi A, Csuk R

Eur J Med Chem. 2018 Jul;155():869-879.
PMID: 29960206 [PubMed - indexed for MEDLINE]

15.

Inhibitory effect of 11-carbonyl-beta-boswellic acid on non-small cell lung cancer H446 cells.
Huang G, Yang J, Zhang L, Cao L, Zhang M, Niu X, Zhou Z, Zhang X, Li P, Liu JF

Biochem Biophys Res Commun. 2018 09;503(4):2202-2205.
PMID: 29953860 [PubMed - indexed for MEDLINE]

16.

Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway.
Wang D, Ge S, Bai J, Song Y

J BUON. 2018 Mar-Apr;23(2):340-345.
PMID: 29745074 [PubMed - as supplied by publisher]

17.

Utilizing biomarkers in colorectal cancer: an interview with Ajay Goel.
Goel A

Future Oncol. 2017 Dec;13(28):2511-2514.
PMID: 29168653 [PubMed - indexed for MEDLINE]

18.

Transcriptomic Profiling of MDA-MB-231 Cells Exposed to and 3-O-Acetyl-B-Boswellic Acid; ER/UPR Mediated Programmed Cell Death.
Mazzio EA, Lewis CA, Soliman KFA

Cancer Genomics Proteomics. 2017 Nov-Dec;14(6):409-425.
PMID: 29109091 [PubMed - indexed for MEDLINE]

19.

Methanolic extract of Boswellia serrata exhibits anti-cancer activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells.
Ranjbarnejad T, Saidijam M, Moradkhani S, Najafi R

Prostaglandins Other Lipid Mediat. 2017 07;131():1-8.
PMID: 28549801 [PubMed - indexed for MEDLINE]

20.

P-gp modulatory acetyl-11-keto-β-boswellic acid based nanoemulsified carrier system for augmented oral chemotherapy of docetaxel.
Pandey G, Mittapelly N, Valicherla GR, Shukla RP, Sharma S, Banala VT, Urandur S, Jajoriya AK, Mitra K, Mishra DP, Gayen JR, Mishra PR

Colloids Surf B Biointerfaces. 2017 Jul;155():276-286.
PMID: 28437753 [PubMed - indexed for MEDLINE]

21.

Boswellia serrata resin extract alleviates azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon tumorigenesis.
Chou YC, Suh JH, Wang Y, Pahwa M, Badmaev V, Ho CT, Pan MH

Mol Nutr Food Res. 2017 09;61(9):.
PMID: 28245338 [PubMed - indexed for MEDLINE]

22.

Design and synthesis of novel 2-substituted 11-keto-boswellic acid heterocyclic derivatives as anti-prostate cancer agents with Pin1 inhibition ability.
Li K, Li L, Wang S, Li X, Ma T, Liu D, Jing Y, Zhao L

Eur J Med Chem. 2017 Jan;126():910-919.
PMID: 27997878 [PubMed - indexed for MEDLINE]

23.

Ring A-modified Derivatives from the Natural Triterpene 3-O-acetyl-11-keto-β-Boswellic Acid and their Cytotoxic Activity.
Li T, Fan P, Ye Y, Luo Q, Lou H

Anticancer Agents Med Chem. 2017;17(8):1153-1167.
PMID: 27928954 [PubMed - indexed for MEDLINE]

24.

Interplay between cell cycle and autophagy induced by boswellic acid analog.
Pathania AS, Guru SK, Kumar S, Kumar A, Ahmad M, Bhushan S, Sharma PR, Mahajan P, Shah BA, Sharma S, Nargotra A, Vishwakarma R, Korkaya H, Malik F

Sci Rep. 2016 Sep;6():33146.
PMID: 27680387 [PubMed - as supplied by publisher]

25.

Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves.
Kohoude MJ, Gbaguidi F, Agbani P, Ayedoun MA, Cazaux S, Bouajila J

Pharm Biol. 2017 Dec;55(1):33-42.
PMID: 27650786 [PubMed - indexed for MEDLINE]

26.

Therapeutic potential of boswellic acids: a patent review (1990-2015).
Hussain H, Al-Harrasi A, Csuk R, Shamraiz U, Green IR, Ahmed I, Khan IA, Ali Z

Expert Opin Ther Pat. 2017 Jan;27(1):81-90.
PMID: 27646163 [PubMed - indexed for MEDLINE]

27.

Role of angiogenic factors of herbal origin in regulation of molecular pathways that control tumor angiogenesis.
Kumar M, Dhatwalia SK, Dhawan DK

Tumour Biol. 2016 Nov;37(11):14341-14354.
PMID: 27614685 [PubMed - indexed for MEDLINE]

28.

Chemical composition, antiproliferative, antioxidant and antibacterial activities of essential oils from aromatic plants growing in Sudan.
Yagi S, Babiker R, Tzanova T, Schohn H

Asian Pac J Trop Med. 2016 Aug;9(8):763-70.
PMID: 27569885 [PubMed - as supplied by publisher]

29.

Reversal of the multidrug resistance of human ileocecal adenocarcinoma cells by acetyl-11-keto-β-boswellic acid via downregulation of P-glycoprotein signals.
Xue X, Chen F, Liu A, Sun D, Wu J, Kong F, Luan Y, Qu X, Wang R

Biosci Trends. 2016 Nov;10(5):392-399.
PMID: 27545217 [PubMed - indexed for MEDLINE]

30.

Improved efficacy of cisplatin in combination with a nano-formulation of pentacyclic triterpenediol.
Alam N, Qayum A, Kumar A, Khare V, Sharma PR, Andotra SS, Singh SK, Koul S, Gupta PN

Mater Sci Eng C Mater Biol Appl. 2016 Nov;68():109-116.
PMID: 27524002 [PubMed - indexed for MEDLINE]

31.

β-Boswellic acid, a bioactive substance used in food supplements, inhibits protein synthesis by targeting the ribosomal machinery.
Casapullo A, Cassiano C, Capolupo A, Del Gaudio F, Esposito R, Tosco A, Riccio R, Monti MC

J Mass Spectrom. 2016 Sep;51(9):821-7.
PMID: 27460774 [PubMed - indexed for MEDLINE]

32.

Boswellic acid disables signal transduction of IL-6-STAT-3 in Ehrlich ascites tumor bearing irradiated mice.
Moustafa EM, Thabet NM, Azab KS

Biochem Cell Biol. 2016 08;94(4):307-13.
PMID: 27458759 [PubMed - indexed for MEDLINE]

33.

Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention.
Biersack B

Noncoding RNA Res. 2016 Oct;1(1):12-34.
PMID: 30159408 [PubMed - as supplied by publisher]

34.

Pharmacological evidences for cytotoxic and antitumor properties of Boswellic acids from Boswellia serrata.
Khan MA, Ali R, Parveen R, Najmi AK, Ahmad S

J Ethnopharmacol. 2016 Sep;191():315-323.
PMID: 27346540 [PubMed - indexed for MEDLINE]

35.

Boswellic acid activity against glioblastoma stem-like cells.
Schneider H, Weller M

Oncol Lett. 2016 Jun;11(6):4187-4192.
PMID: 27313764 [PubMed - as supplied by publisher]

36.

Frankincense--therapeutic properties.
Al-Yasiry AR, Kiczorowska B

Postepy Hig Med Dosw (Online). 2016 Jan;70():380-91.
PMID: 27117114 [PubMed - indexed for MEDLINE]

37.

The potential role of boswellic acids in cancer prevention and treatment.
Roy NK, Deka A, Bordoloi D, Mishra S, Kumar AP, Sethi G, Kunnumakkara AB

Cancer Lett. 2016 07;377(1):74-86.
PMID: 27091399 [PubMed - indexed for MEDLINE]

38.

Use of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma.
Bonucci M, Fioranelli M, Roccia MG, Di Nardo V, Carolina JA, Lotti T

Dermatol Ther. 2016 11;29(6):393.
PMID: 27003094 [PubMed - indexed for MEDLINE]

39.

Synthesis of β-boswellic acid derivatives as cytotoxic and apoptotic agents.
Kumar A, Qayum A, Sharma PR, Singh SK, Shah BA

Bioorg Med Chem Lett. 2016 Jan;26(1):76-81.
PMID: 26608550 [PubMed - indexed for MEDLINE]

40.

Phytochemical Analysis and Anti-cancer Investigation of Boswellia serrata Bioactive Constituents In Vitro.
Ahmed HH, Abd-Rabou AA, Hassan AZ, Kotob SE

Asian Pac J Cancer Prev. 2015;16(16):7179-88.
PMID: 26514509 [PubMed - indexed for MEDLINE]

41.

Triggering of Suicidal Erythrocyte Death Following Boswellic Acid Exposure.
Calabrò S, Alzoubi K, Faggio C, Laufer S, Lang F

Cell Physiol Biochem. 2015;37(1):131-42.
PMID: 26303375 [PubMed - indexed for MEDLINE]

42.

Combination of Anti-Diabetic Drug Metformin and Boswellic Acid Nanoparticles: A Novel Strategy for Pancreatic Cancer Therapy.
Snima KS, Nair RS, Nair SV, Kamath CR, Lakshmanan VK

J Biomed Nanotechnol. 2015 Jan;11(1):93-104.
PMID: 26301303 [PubMed - indexed for MEDLINE]

43.

Boswellic acids synergize antitumor activity and protect against the cardiotoxicity of doxorubicin in mice bearing Ehrlich's carcinoma.
Ali SA, Zaitone SA, Moustafa YM

Can J Physiol Pharmacol. 2015 Aug;93(8):695-708.
PMID: 26230640 [PubMed - indexed for MEDLINE]

44.

11-Keto-boswellic acid derived amides and monodesmosidic saponins induce apoptosis in breast and cervical cancers cells.
Csuk R, Barthel-Niesen A, Barthel A, Schäfer R, Al-Harrasi A

Eur J Med Chem. 2015 Jul;100():98-105.
PMID: 26073487 [PubMed - indexed for MEDLINE]

45.

Synthesis and structure-activity relationships of boswellic acid derivatives as potent VEGFR-2 inhibitors.
Shen S, Xu X, Liu Z, Liu J, Hu L

Bioorg Med Chem. 2015 May;23(9):1982-93.
PMID: 25819335 [PubMed - indexed for MEDLINE]

46.

Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer.
Toden S, Okugawa Y, Buhrmann C, Nattamai D, Anguiano E, Baldwin N, Shakibaei M, Boland CR, Goel A

Cancer Prev Res (Phila). 2015 May;8(5):431-43.
PMID: 25712055 [PubMed - indexed for MEDLINE]

47.

Prediction of anticancer property of bowsellic acid derivatives by quantitative structure activity relationship analysis and molecular docking study.
Satpathy R, Guru RK, Behera R, Nayak B

J Pharm Bioallied Sci. 2015 Jan-Mar;7(1):21-5.
PMID: 25709332 [PubMed - as supplied by publisher]

48.

Synthesis and antitumor activity of ring A modified 11-keto-β-boswellic acid derivatives.
Csuk R, Niesen-Barthel A, Schäfer R, Barthel A, Al-Harrasi A

Eur J Med Chem. 2015 Mar;92():700-11.
PMID: 25618017 [PubMed - indexed for MEDLINE]

49.

Retraction notice to "Acetyl-11-β-boswellic acid (AKBA)inhibits human gastric carcinoma growth through modulation of the Wnt/β-canetin signalin pathway" Biochimica et Biophysica Acta [1830 (6) 3604-3615].

Biochim Biophys Acta. 2015 Jan;1850(1):254.
PMID: 25610930 [PubMed - as supplied by publisher]

50.

Retraction notice to "Acetyl-11-keto-beta-boswellic acid (AKBA) prevents human colonic adenocarcinoma growth through modulation of multiple signaling pathways" Biochimica et Biophysica Acta [1830 (10) 4907-4916].

Biochim Biophys Acta. 2015 Jan;1850(1):253.
PMID: 25610929 [PubMed - as supplied by publisher]

51.

The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA145 are potentiated by autophagy inhibitors.
Pathania AS, Wani ZA, Guru SK, Kumar S, Bhushan S, Korkaya H, Seals DF, Kumar A, Mondhe DM, Ahmed Z, Chandan BK, Malik F

Mol Cancer. 2015 Jan;14():6.
PMID: 25608686 [PubMed - indexed for MEDLINE]

52.

An α-acetoxy-tirucallic acid isomer inhibits Akt/mTOR signaling and induces oxidative stress in prostate cancer cells.
El Gaafary M, Büchele B, Syrovets T, Agnolet S, Schneider B, Schmidt CQ, Simmet T

J Pharmacol Exp Ther. 2015 Jan;352(1):33-42.
PMID: 25316122 [PubMed - indexed for MEDLINE]

53.

Effect of boswellia thurifera gum methanol extract on cytotoxicity and p53 gene expression in human breast cancer cell line.
Yazdanpanahi N, Behbahani M, Yektaeian A

Iran J Pharm Res. 2014;13(2):719-24.
PMID: 25237368 [PubMed - as supplied by publisher]

54.

Caspase mediated synergistic effect of Boswellia serrata extract in combination with doxorubicin against human hepatocellular carcinoma.
Khan MA, Singh M, Khan MS, Najmi AK, Ahmad S

Biomed Res Int. 2014;2014():294143.
PMID: 25177685 [PubMed - indexed for MEDLINE]

55.

Design, synthesis and biological evaluation of β-boswellic acid based HDAC inhibitors as inducers of cancer cell death.
Sharma S, Ahmad M, Bhat JA, Kumar A, Kumar M, Zargar MA, Hamid A, Shah BA

Bioorg Med Chem Lett. 2014 Oct;24(19):4729-4734.
PMID: 25176189 [PubMed - indexed for MEDLINE]

56.

Differential effects of selective frankincense (Ru Xiang) essential oil versus non-selective sandalwood (Tan Xiang) essential oil on cultured bladder cancer cells: a microarray and bioinformatics study.
Dozmorov MG, Yang Q, Wu W, Wren J, Suhail MM, Woolley CL, Young DG, Fung KM, Lin HK

Chin Med. 2014;9():18.
PMID: 25006348 [PubMed - as supplied by publisher]

57.

Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells.
Thummuri D, Jeengar MK, Shrivastava S, Areti A, Yerra VG, Yamjala S, Komirishetty P, Naidu VG, Kumar A, Sistla R

Environ Toxicol Pharmacol. 2014 Jul;38(1):58-70.
PMID: 24908637 [PubMed - indexed for MEDLINE]

58.

Ultrastructural and hormonal changes in rat cauda epididymal spermatozoa induced by Boswellia papyrifera and Boswellia carterii.
Ahmed M, Ali D, Harrath AH, Hussain T, Al-Daghri N, Alokail MS, Aladakatti RH, Ghodesawar MA

C R Biol. 2014 Apr;337(4):250-7.
PMID: 24702894 [PubMed - indexed for MEDLINE]

59.

The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice.
Wang R, Wang Y, Gao Z, Qu X

Drug Discov Ther. 2014 Feb;8(1):25-32.
PMID: 24647155 [PubMed - indexed for MEDLINE]

60.

Major constituents of Boswellia carteri resin exhibit cyclooxygenase enzyme inhibition and antiproliferative activity.
Ali SI, Zhang CR, Mohamed AA, El-Baz FK, Hegazy AK, Kord MA, Nair MG

Nat Prod Commun. 2013 Oct;8(10):1365-6.
PMID: 24354175 [PubMed - indexed for MEDLINE]

61.

Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059.
Pathania AS, Joshi A, Kumar S, Guru SK, Bhushan S, Sharma PR, Bhat WW, Saxena AK, Singh J, Shah BA, Andotra SS, Taneja SC, Malik FA, Kumar A

Apoptosis. 2013 Dec;18(12):1561-73.
PMID: 23948751 [PubMed - indexed for MEDLINE]

62.

Acetyl-11-keto-beta-boswellic acid (AKBA) prevents human colonic adenocarcinoma growth through modulation of multiple signaling pathways.
Yuan Y, Cui SX, Wang Y, Ke HN, Wang RQ, Lou HX, Gao ZH, Qu XJ

Biochim Biophys Acta. 2013 Oct;1830(10):4907-16.
PMID: 23850473 [PubMed - indexed for MEDLINE]

63.

Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105.
Khan MK, Ansari IA, Khan MS, Arif JM

Pharmacogn Mag. 2013 Jan;9(33):51-7.
PMID: 23661994 [PubMed - as supplied by publisher]

64.

Boswellic acid and its inhibitory effect on tumor growth in systemic malignancies: an emerging concept in oncology.
Kapoor S

Future Oncol. 2013 May;9(5):627-8.
PMID: 23647290 [PubMed - indexed for MEDLINE]

65.

Acetyl-11-keto-β-boswellic acid (AKBA) inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway.
Zhang YS, Xie JZ, Zhong JL, Li YY, Wang RQ, Qin YZ, Lou HX, Gao ZH, Qu XJ

Biochim Biophys Acta. 2013 Jun;1830(6):3604-15.
PMID: 23500016 [PubMed - indexed for MEDLINE]

66.

Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model.
Ni X, Suhail MM, Yang Q, Cao A, Fung KM, Postier RG, Woolley C, Young G, Zhang J, Lin HK

BMC Complement Altern Med. 2012 Dec;12():253.
PMID: 23237355 [PubMed - indexed for MEDLINE]

67.

Enhanced anticancer potential of encapsulated solid lipid nanoparticles of TPD: a novel triterpenediol from Boswellia serrata.
Bhushan S, Kakkar V, Pal HC, Guru SK, Kumar A, Mondhe DM, Sharma PR, Taneja SC, Kaur IP, Singh J, Saxena AK

Mol Pharm. 2013 Jan;10(1):225-35.
PMID: 23237302 [PubMed - indexed for MEDLINE]

68.

A novel semisynthetic inhibitor of the FRB domain of mammalian target of rapamycin blocks proliferation and triggers apoptosis in chemoresistant prostate cancer cells.
Morad SA, Schmid M, Büchele B, Siehl HU, El Gafaary M, Lunov O, Syrovets T, Simmet T

Mol Pharmacol. 2013 Feb;83(2):531-41.
PMID: 23208958 [PubMed - indexed for MEDLINE]

69.

NF-κB down-regulation and PARP cleavage by novel 3-α-butyryloxy-β-boswellic acid results in cancer cell specific apoptosis and in vivo tumor regression.
Qurishi Y, Hamid A, Sharma PR, Wani ZA, Mondhe DM, Singh SK, Zargar MA, Andotra SS, Shah BA, Taneja SC, Saxena AK

Anticancer Agents Med Chem. 2013 Jun;13(5):777-90.
PMID: 23157593 [PubMed - indexed for MEDLINE]

70.

Chemoprevention of intestinal adenomatous polyposis by acetyl-11-keto-beta-boswellic acid in APC(Min/+) mice.
Liu HP, Gao ZH, Cui SX, Wang Y, Li BY, Lou HX, Qu XJ

Int J Cancer. 2013 Jun;132(11):2667-81.
PMID: 23132636 [PubMed - indexed for MEDLINE]

71.

Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family.
Takahashi M, Sung B, Shen Y, Hur K, Link A, Boland CR, Aggarwal BB, Goel A

Carcinogenesis. 2012 Dec;33(12):2441-9.
PMID: 22983985 [PubMed - indexed for MEDLINE]

72.

PARP cleavage and perturbance in mitochondrial membrane potential by 3-α-propionyloxy-β-boswellic acid results in cancer cell death and tumor regression in murine models.
Qurishi Y, Hamid A, Sharma PR, Wani ZA, Mondhe DM, Singh SK, Zargar MA, Andotra SS, Shah BA, Taneja SC, Saxena AK

Future Oncol. 2012 Jul;8(7):867-81.
PMID: 22830406 [PubMed - indexed for MEDLINE]

73.

Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells.
Shen Y, Takahashi M, Byun HM, Link A, Sharma N, Balaguer F, Leung HC, Boland CR, Goel A

Cancer Biol Ther. 2012 May;13(7):542-52.
PMID: 22415137 [PubMed - indexed for MEDLINE]

74.

[Chemopreventive effect of boswellic acid and curcumin on 7,12-dimethyl benzanthracene-induced hamster cheek pouch carcinogenesis].
Zhang XY, Chen XF, Sun Z, Miao CC, Ge LH, Tian ZC

Zhonghua Kou Qiang Yi Xue Za Zhi. 2011 Nov;46(11):678-83.
PMID: 22333308 [PubMed - indexed for MEDLINE]

75.

Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells.
Suhail MM, Wu W, Cao A, Mondalek FG, Fung KM, Shih PT, Fang YT, Woolley C, Young G, Lin HK

BMC Complement Altern Med. 2011 Dec;11():129.
PMID: 22171782 [PubMed - indexed for MEDLINE]

76.

Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.
Park B, Prasad S, Yadav V, Sung B, Aggarwal BB

PLoS One. 2011;6(10):e26943.
PMID: 22066019 [PubMed - indexed for MEDLINE]

77.

Targeting Sp1 transcription factors in prostate cancer therapy.
Sankpal UT, Goodison S, Abdelrahim M, Basha R

Med Chem. 2011 Sep;7(5):518-25.
PMID: 22022994 [PubMed - indexed for MEDLINE]

78.

Potentiation of the antitumor effect of 11-keto-β-boswellic acid by its 3-α-hexanoyloxy derivative.
Chashoo G, Singh SK, Mondhe DM, Sharma PR, Andotra SS, Shah BA, Taneja SC, Saxena AK

Eur J Pharmacol. 2011 Oct;668(3):390-400.
PMID: 21821018 [PubMed - indexed for MEDLINE]

79.

A novel cyano derivative of 11-keto-β-boswellic acid causes apoptotic death by disrupting PI3K/AKT/Hsp-90 cascade, mitochondrial integrity, and other cell survival signaling events in HL-60 cells.
Khan S, Kaur R, Shah BA, Malik F, Kumar A, Bhushan S, Jain SK, Taneja SC, Singh J

Mol Carcinog. 2012 Sep;51(9):679-95.
PMID: 21751262 [PubMed - indexed for MEDLINE]

80.

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Int J Cancer. 2012 May;130(9):2176-84.
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82.

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Food Chem Toxicol. 2011 Sep;49(9):1924-34.
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83.

Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression.
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Int J Cancer. 2011 Jul;129(1):23-33.
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84.

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Eur J Pharmacol. 2011 Jun;660(2-3):241-8.
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85.

A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid.
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Eur J Med Chem. 2011 Apr;46(4):1356-66.
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86.

[Effect of acetyl-11-keto-β-boswellic acid on proliferation, apoptosis and cell cycle of human acute myeloid leukemia cell line HL-60].
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87.

[Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1].
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Zhong Xi Yi Jie He Xue Bao. 2010 Nov;8(11):1060-9.
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88.

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Chem Biol Interact. 2011 Jan;189(1-2):60-71.
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Eur J Med Chem. 2010 Sep;45(9):3840-3.
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Invest New Drugs. 2011 Oct;29(5):1081-9.
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Mol Pharmacol. 2010 Mar;77(3):378-87.
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Lipids Health Dis. 2009 Dec;8():51.
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Anticancer Res. 2009 Aug;29(8):2987-91.
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Cancer Res. 2009 Jul;69(14):5893-900.
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96.

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Mol Carcinog. 2009 Dec;48(12):1093-108.
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BMC Complement Altern Med. 2009 Mar;9():7.
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Biochem Pharmacol. 2008 Jun;75(11):2112-21.
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Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo.
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[Experimental study on induction of apoptosis of leukemic cells by Boswellia carterii Birdw extractive].
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J Neurooncol. 2000;46(2):97-103.
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Br J Cancer. 1999 May;80(5-6):756-65.
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