Erste Untersuchungen mit einem Extrakt aus salai guggal und Boswelliasäuren auf Entzündungsfaktoren aus der Acharidonsäurekaskade und andere Entzündungsfaktoren wurden am Lehrstuhl Pharmakologie des Pharmazeutischen Instituts der Universität Tübingen nach einem Treffen mit Dr. G.B. Sing aus Jammu (Indien) durchgeführt.
In vitro effects of an alcoholic extract from gum resin of Boswellia serrata AKBA/KBA on formation of 5-LOX products and elastase activity from polymorphnuclear leucozytes (PMNL)
aus: Ammon et al. 1991 und Safayhi et al. 1992
Hier noch einige der wichtigsten Ergebnisse unseres Instituts:
Publikationen
| 1. | Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii. Su S, Hua Y, Wang Y, Gu W, Zhou W, Duan JA, Jiang H, Chen T, Tang Y
J Ethnopharmacol. 2012 Jan;139(2):649-56.
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| 2. | Boswellic acids from frankincense inhibit lipopolysaccharide functionality through direct molecular interference. Henkel A, Kather N, Mönch B, Northoff H, Jauch J, Werz O
Biochem Pharmacol. 2012 Jan;83(1):115-21.
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| 3. | Anti-inflammatory, antinociceptive and antioxidant activities of the endemic Soqotraen Boswellia elongata Balf. f. and Jatropha unicostata Balf. f. in different experimental models. Mothana RA
Food Chem Toxicol. 2011 Oct;49(10):2594-9.
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| 4. | Growth inhibitory, apoptotic and anti-inflammatory activities displayed by a novel modified triterpenoid, cyano enone of methyl boswellates. Ravanan P, Singh SK, Rao GS, Kondaiah P
J Biosci. 2011 Jun;36(2):297-307.
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| 5. | Inhibition of microsomal prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense. Siemoneit U, Koeberle A, Rossi A, Dehm F, Verhoff M, Reckel S, Maier TJ, Jauch J, Northoff H, Bernhard F, Doetsch V, Sautebin L, Werz O
Br J Pharmacol. 2011 Jan;162(1):147-62.
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| 6. | Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage. Blain EJ, Ali AY, Duance VC
Phytother Res. 2010 Jun;24(6):905-12.
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| 7. | Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation. Cao H, Yu R, Choi Y, Ma ZZ, Zhang H, Xiang W, Lee DY, Berman BM, Moudgil KD, Fong HH, van Breemen RB
Pharmacol Res. 2010 Jun;61(6):519-24.
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| 8. | Comparative study of the chemical composition and antioxidant activity of six essential oils and their components. Yang SA, Jeon SK, Lee EJ, Shim CH, Lee IS
Nat Prod Res. 2010;24(2):140-51.
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| 9. | Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense. Tausch L, Henkel A, Siemoneit U, Poeckel D, Kather N, Franke L, Hofmann B, Schneider G, Angioni C, Geisslinger G, Skarke C, Holtmeier W, Beckhaus T, Karas M, Jauch J, Werz O
J Immunol. 2009 Sep;183(5):3433-42.
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| 10. | On the interference of boswellic acids with 5-lipoxygenase: mechanistic studies in vitro and pharmacological relevance. Siemoneit U, Pergola C, Jazzar B, Northoff H, Skarke C, Jauch J, Werz O
Eur J Pharmacol. 2009 Mar;606(1-3):246-54.
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| 11. | Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island Soqotra. Mothana RA, Lindequist U, Gruenert R, Bednarski PJ
BMC Complement Altern Med. 2009;9(0):7.
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| 12. | Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids. Siemoneit U, Hofmann B, Kather N, Lamkemeyer T, Madlung J, Franke L, Schneider G, Jauch J, Poeckel D, Werz O
Biochem Pharmacol. 2008 Jan;75(2):503-13.
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| 13. | Boswellic acids stimulate arachidonic acid release and 12-lipoxygenase activity in human platelets independent of Ca2+ and differentially interact with platelet-type 12-lipoxygenase. Poeckel D, Tausch L, Kather N, Jauch J, Werz O
Mol Pharmacol. 2006 Sep;70(3):1071-8.
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| 14. | 3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells. Poeckel D, Tausch L, George S, Jauch J, Werz O
J Pharmacol Exp Ther. 2006 Jan;316(1):224-32.
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| 15. | Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid. Poeckel D, Tausch L, Altmann A, Feisst C, Klinkhardt U, Graff J, Harder S, Werz O
Br J Pharmacol. 2005 Oct;146(4):514-24.
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| 16. | Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property. Pandey RS, Singh BK, Tripathi YB
Indian J Exp Biol. 2005 Jun;43(6):509-16.
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| 17. | Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Altmann A, Poeckel D, Fischer L, Schubert-Zsilavecz M, Steinhilber D, Werz O
Br J Pharmacol. 2004 Jan;141(2):223-32.
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| 18. | Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors. Fischer L, Szellas D, Rådmark O, Steinhilber D, Werz O
FASEB J. 2003 May;17(8):949-51.
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| 19. | Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization. Altmann A, Fischer L, Schubert-Zsilavecz M, Steinhilber D, Werz O
Biochem Biophys Res Commun. 2002 Jan;290(1):185-90.
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| 20. | Stimulation of leukotriene synthesis in intact polymorphonuclear cells by the 5-lipoxygenase inhibitor 3-oxo-tirucallic acid. Boden SE, Schweizer S, Bertsche T, Düfer M, Drews G, Safayhi H
Mol Pharmacol. 2001 Aug;60(2):267-73.
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| 21. | Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues. Schweizer S, von Brocke AF, Boden SE, Bayer E, Ammon HP, Safayhi H
J Nat Prod. 2000 Aug;63(8):1058-61.
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| 22. | Concentration-dependent potentiating and inhibitory effects of Boswellia extracts on 5-lipoxygenase product formation in stimulated PMNL. Safayhi H, Boden SE, Schweizer S, Ammon HP
Planta Med. 2000 Mar;66(2):110-3.
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| 23. | Characterization of an acetyl-11-keto-beta-boswellic acid and arachidonate-binding regulatory site of 5-lipoxygenase using photoaffinity labeling. Sailer ER, Schweizer S, Boden SE, Ammon HP, Safayhi H
Eur J Biochem. 1998 Sep;256(2):364-8.
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| 24. | Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity. Werz O, Szellas D, Henseler M, Steinhilber D
Mol Pharmacol. 1998 Aug;54(2):445-51.
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| 25. | Inhibition by boswellic acids of human leukocyte elastase. Safayhi H, Rall B, Sailer ER, Ammon HP
J Pharmacol Exp Ther. 1997 Apr;281(1):460-3.
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| 26. | Acetyl-11-keto-beta-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity. Sailer ER, Subramanian LR, Rall B, Hoernlein RF, Ammon HP, Safayhi H
Br J Pharmacol. 1996 Feb;117(4):615-8.
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| 27. | Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid. Safayhi H, Sailer ER, Ammon HP
Mol Pharmacol. 1995 Jun;47(6):1212-6.
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| 28. | Mechanism of antiinflammatory actions of curcumine and boswellic acids. Ammon HP, Safayhi H, Mack T, Sabieraj J
J Ethnopharmacol. 1993 Mar;38(2-3):113-9.
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| 29. | Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. Safayhi H, Mack T, Sabieraj J, Anazodo MI, Subramanian LR, Ammon HP
J Pharmacol Exp Ther. 1992 Jun;261(3):1143-6.
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| 30. | Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata. Ammon HP, Mack T, Singh GB, Safayhi H
Planta Med. 1991 Jun;57(3):203-7.
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