9.1.2 Immunsystem

 

 Es ist offenbar, dass wohl im Wesentlichen Teile des Immunsystems, die an Autoimmunerkrankungen beteiligt sind, als Ziel der Wirkung von Boswelliasäuren infrage kommen.


Publikationen

1. Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs.
Kumar A, Shah BA, Singh S, Hamid A, Singh SK, Sethi VK, Saxena AK, Singh J, Taneja SC

Bioorg Med Chem Lett. 2012 Jan;22(1):431-5.
PMID: 22123322 [PubMed - as supplied by publisher]

2. Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes.
Akhtar N, Miller MJ, Haqqi TM

BMC Complement Altern Med. 2011;11(0):66.
PMID: 21854562 [PubMed - indexed for MEDLINE]

3. Gum resin of Boswellia serrata inhibited human monocytic (THP-1) cell activation and platelet aggregation.
Kokkiripati PK, Bhakshu LM, Marri S, Padmasree K, Row AT, Raghavendra AS, Tetali SD

J Ethnopharmacol. 2011 Sep;137(1):893-901.
PMID: 21771654 [PubMed - indexed for MEDLINE]

4. Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract.
Sengupta K, Kolla JN, Krishnaraju AV, Yalamanchili N, Rao CV, Golakoti T, Raychaudhuri S, Raychaudhuri SP

Mol Cell Biochem. 2011 Aug;354(1-2):189-97.
PMID: 21479939 [PubMed - indexed for MEDLINE]

5. Immunological adjuvant effect of Boswellia serrata (BOS 2000) on specific antibody and cellular response to ovalbumin in mice.
Gupta A, Khajuria A, Singh J, Singh S, Suri KA, Qazi GN

Int Immunopharmacol. 2011 Aug;11(8):968-75.
PMID: 21371582 [PubMed - indexed for MEDLINE]

6. Traditional herbal remedies that influence cell adhesion molecule activity.
Spelman K, Aldag R, Hamman A, Kwasnik EM, Mahendra MA, Obasi TM, Morse J, Williams EJ

Phytother Res. 2011 Apr;25(4):473-83.
PMID: 21105177 [PubMed - indexed for MEDLINE]

7. Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity.
Subba Rao GS, Kondaiah P, Singh SK, Ravanan P, Sporn MB

Tetrahedron. 2008 Dec;64(51):11541-11548.
PMID: 20622928 [PubMed - as supplied by publisher]

8. Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage.
Blain EJ, Ali AY, Duance VC

Phytother Res. 2010 Jun;24(6):905-12.
PMID: 19943332 [PubMed - indexed for MEDLINE]

9. Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis.
Wang H, Syrovets T, Kess D, Büchele B, Hainzl H, Lunov O, Weiss JM, Scharffetter-Kochanek K, Simmet T

J Immunol. 2009 Oct;183(7):4755-63.
PMID: 19752240 [PubMed - indexed for MEDLINE]

10. Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration.
Popovic M, Laumonnier Y, Burysek L, Syrovets T, Simmet T

J Leukoc Biol. 2008 Jul;84(1):215-23.
PMID: 18436581 [PubMed - indexed for MEDLINE]

11. Immunomodulatory activity of biopolymeric fraction BOS 2000 from Boswellia serrata.
Khajuria A, Gupta A, Suden P, Singh S, Malik F, Singh J, Gupta BD, Suri KA, Srinivas VK, Ella K, Qazi GN

Phytother Res. 2008 Mar;22(3):340-8.
PMID: 18167047 [PubMed - indexed for MEDLINE]

12. Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice.
Cuaz-Pérolin C, Billiet L, Baugé E, Copin C, Scott-Algara D, Genze F, Büchele B, Syrovets T, Simmet T, Rouis M

Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):272-7.
PMID: 18032778 [PubMed - indexed for MEDLINE]

13. Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation.
Moussaieff A, Shohami E, Kashman Y, Fride E, Schmitz ML, Renner F, Fiebich BL, Munoz E, Ben-Neriah Y, Mechoulam R

Mol Pharmacol. 2007 Dec;72(6):1657-64.
PMID: 17895408 [PubMed - indexed for MEDLINE]

14. A new vaccine adjuvant (BOS 2000) a potent enhancer mixed Th1/Th2 immune responses in mice immunized with HBsAg.
Khajuria A, Gupta A, Malik F, Singh S, Singh J, Gupta BD, Suri KA, Suden P, Srinivas VK, Ella K, Qazi GN

Vaccine. 2007 Jun;25(23):4586-94.
PMID: 17498851 [PubMed - indexed for MEDLINE]

15. Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFalpha, IL-1beta, NO and MAP kinases.
Gayathri B, Manjula N, Vinaykumar KS, Lakshmi BS, Balakrishnan A

Int Immunopharmacol. 2007 Apr;7(4):473-82.
PMID: 17321470 [PubMed - indexed for MEDLINE]

16. Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.
Takada Y, Ichikawa H, Badmaev V, Aggarwal BB

J Immunol. 2006 Mar;176(5):3127-40.
PMID: 16493072 [PubMed - indexed for MEDLINE]

17. Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property.
Pandey RS, Singh BK, Tripathi YB

Indian J Exp Biol. 2005 Jun;43(6):509-16.
PMID: 15991575 [PubMed - indexed for MEDLINE]

18. Boswellia carterii extract inhibits TH1 cytokines and promotes TH2 cytokines in vitro.
Chevrier MR, Ryan AE, Lee DY, Zhongze M, Wu-Yan Z, Via CS

Clin Diagn Lab Immunol. 2005 May;12(5):575-80.
PMID: 15879017 [PubMed - indexed for MEDLINE]

19. Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells.
Roy S, Khanna S, Shah H, Rink C, Phillips C, Preuss H, Subbaraju GV, Trimurtulu G, Krishnaraju AV, Bagchi M, Bagchi D, Sen CK

DNA Cell Biol. 2005 Apr;24(4):244-55.
PMID: 15812241 [PubMed - indexed for MEDLINE]

20. Acetyl-boswellic acids inhibit lipopolysaccharide-mediated TNF-alpha induction in monocytes by direct interaction with IkappaB kinases.
Syrovets T, Büchele B, Krauss C, Laumonnier Y, Simmet T

J Immunol. 2005 Jan;174(1):498-506.
PMID: 15611276 [PubMed - indexed for MEDLINE]

21. Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb.
Pungle P, Banavalikar M, Suthar A, Biyani M, Mengi S

Indian J Exp Biol. 2003 Dec;41(12):1460-2.
PMID: 15320503 [PubMed - indexed for MEDLINE]

22. Immunomodulatory triterpenoids from the oleogum resin of Boswellia carterii Birdwood.
Badria FA, Mikhaeil BR, Maatooq GT, Amer MM

Z Naturforsch C. 2003 Jul-Aug;58(7-8):505-16.
PMID: 12939036 [PubMed - indexed for MEDLINE]

23. Chemistry and immunomodulatory activity of frankincense oil.
Mikhaeil BR, Maatooq GT, Badria FA, Amer MM

Z Naturforsch C. 2003 Mar-Apr;58(3-4):230-8.
PMID: 12710734 [PubMed - indexed for MEDLINE]

24. Boswellic acid, a potent antiinflammatory drug, inhibits rejection to the same extent as high dose steroids.
Dahmen U, Gu YL, Dirsch O, Fan LM, Li J, Shen K, Broelsch CE

Transplant Proc. 2001 Feb-Mar;33(1-2):539-41.
PMID: 11266947 [PubMed - indexed for MEDLINE]

25. Anticomplementary activity of boswellic acids--an inhibitor of C3-convertase of the classical complement pathway.
Kapil A, Moza N

Int J Immunopharmacol. 1992 Oct;14(7):1139-43.
PMID: 1452399 [PubMed - indexed for MEDLINE]

26. Effect of salai guggal ex-Boswellia serrata on cellular and humoral immune responses and leucocyte migration.
Sharma ML, Khajuria A, Kaul A, Singh S, Singh GB, Atal CK

Agents Actions. 1988 Jun;24(1-2):161-4.
PMID: 3407547 [PubMed - indexed for MEDLINE]