Der erste Bericht über eine Antitumoraktiviträt von Extrakten von Boswellia serrata stammt von Jing und Mitarbeitern (1992) unter Verwendung von menschlichen HL 60 Leukämiezellen.
Untersuchungen, die 1999 in Tübingen durchgeführt wurden, zeigten ebenfalls eine Antitumorwirkung bei HL 60 Leukämiezellen sowie bei Glioblastomzellen. Es stellte sich jedoch bei all diesen Untersuchungen heraus, dass die in vitro verwendeten Konzentrationen von Boswelliaextrakten und Boswelliasäuren, die zur Hemmung des Tumorwachstums notwendig waren, wesentlich höher lagen als diejenigen, die eine Hemmung der Leukotriensynthese in Leukozyten bewirkten, wie dies auch aus der Tabelle hervorgeht. Andererseits ist es jedoch denkbar, dass niedrigere Konzentrationen von Boswelliasäuren bei solchen Tumoren wirksam sein könnten, die eng mit einer erhöhten Bildung von Leukotrien verbunden sind.
Hier einige Daten aus dem Tübinger Institut:
Publikationen
| 1. | Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells. Suhail MM, Wu W, Cao A, Mondalek FG, Fung KM, Shih PT, Fang YT, Woolley C, Young G, Lin HK
BMC Complement Altern Med. 2011;11(0):129.
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| 2. | Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets. Park B, Prasad S, Yadav V, Sung B, Aggarwal BB
PLoS One. 2011;6(10):e26943.
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| 3. | Targeting Sp1 transcription factors in prostate cancer therapy. Sankpal UT, Goodison S, Abdelrahim M, Basha R
Med Chem. 2011 Sep;7(5):518-25.
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| 4. | Potentiation of the antitumor effect of 11-keto-β-boswellic acid by its 3-α-hexanoyloxy derivative. Chashoo G, Singh SK, Mondhe DM, Sharma PR, Andotra SS, Shah BA, Taneja SC, Saxena AK
Eur J Pharmacol. 2011 Oct;668(3):390-400.
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| 5. | Antitumor properties of Boswellic acid against Ehrlich ascites cells bearing mouse. Agrawal SS, Saraswati S, Mathur R, Pandey M
Food Chem Toxicol. 2011 Sep;49(9):1924-34.
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| 6. | A Novel cyano derivative of 11-Keto-β-Boswellic acid causes apoptotic death by disrupting PI3K/AKT/Hsp-90 cascade, mitochondrial integrity, and other cell survival signaling events in HL-60 cells. Khan S, Kaur R, Shah BA, Malik F, Kumar A, Bhushan S, Jain SK, Taneja SC, Singh J
Mol Carcinog. 2011 Jul;0(0):0.
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| 7. | Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers. Yadav VR, Prasad S, Sung B, Gelovani JG, Guha S, Krishnan S, Aggarwal BB
Int J Cancer. 2011 Jun;0(0):0.
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| 8. | Growth inhibitory, apoptotic and anti-inflammatory activities displayed by a novel modified triterpenoid, cyano enone of methyl boswellates. Ravanan P, Singh SK, Rao GS, Kondaiah P
J Biosci. 2011 Jun;36(2):297-307.
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| 9. | A cyano analogue of boswellic acid induces crosstalk between p53/PUMA/Bax and telomerase that stages the human papillomavirus type 18 positive HeLa cells to apoptotic death. Khan S, Chib R, Shah BA, Wani ZA, Dhar N, Mondhe DM, Lattoo S, Jain SK, Taneja SC, Singh J
Eur J Pharmacol. 2011 Jun;660(2-3):241-8.
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| 10. | Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression. Park B, Sung B, Yadav VR, Cho SG, Liu M, Aggarwal BB
Int J Cancer. 2011 Jul;129(1):23-33.
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| 11. | A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid. Kaur R, Khan S, Chib R, Kaur T, Sharma PR, Singh J, Shah BA, Taneja SC
Eur J Med Chem. 2011 Apr;46(4):1356-66.
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| 12. | A propionyloxy derivative of 11-keto-β-boswellic acid induces apoptosis in HL-60 cells mediated through topoisomerase I & II inhibition. Chashoo G, Singh SK, Sharma PR, Mondhe DM, Hamid A, Saxena A, Andotra SS, Shah BA, Qazi NA, Taneja SC, Saxena AK
Chem Biol Interact. 2011 Jan;189(1-2):60-71.
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| 13. | [Effect of acetyl-11-keto-β-boswellic acid on proliferation, apoptosis and cell cycle of human acute myeloid leukemia cell line HL-60]. Yuan XY, Li YH, Qi ZH, Peng MY, Wan Z, Wang GP, Chen FP
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Dec;18(6):1440-4.
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| 14. | [Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1]. Liang YH, Li P, Zhao JX, Liu X, Huang QF
Zhong Xi Yi Jie He Xue Bao. 2010 Nov;8(11):1060-9.
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| 15. | Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity. Subba Rao GS, Kondaiah P, Singh SK, Ravanan P, Sporn MB
Tetrahedron. 2008 Dec;64(51):11541-11548.
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| 16. | Synthesis of an antitumor active endoperoxide from 11-keto-beta-boswellic acid. Csuk R, Niesen-Barthel A, Barthel A, Kluge R, Ströhl D
Eur J Med Chem. 2010 Sep;45(9):3840-3.
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| 17. | Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells. Estrada AC, Syrovets T, Pitterle K, Lunov O, Büchele B, Schimana-Pfeifer J, Schmidt T, Morad SA, Simmet T
Mol Pharmacol. 2010 Mar;77(3):378-87.
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| 18. | [Cembrane diterpenes in olibanum]. Wang F, Li Z, Liu T, Hua H
Zhongguo Zhong Yao Za Zhi. 2009 Oct;34(19):2477-80.
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| 19. | Boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells. Zhang Y, Duan RD
Lipids Health Dis. 2009;8(0):51.
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| 20. | Activation of p53/p21/PUMA alliance and disruption of PI-3/Akt in multimodal targeting of apoptotic signaling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata. Bhushan S, Malik F, Kumar A, Isher HK, Kaur IP, Taneja SC, Singh J
Mol Carcinog. 2009 Dec;48(12):1093-108.
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| 21. | LY294002 enhances boswellic acid-induced apoptosis in colon cancer cells. Liu JJ, Duan RD
Anticancer Res. 2009 Aug;29(8):2987-91.
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| 22. | Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. Pang X, Yi Z, Zhang X, Sung B, Qu W, Lian X, Aggarwal BB, Liu M
Cancer Res. 2009 Jul;69(14):5893-900.
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| 23. | Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island Soqotra. Mothana RA, Lindequist U, Gruenert R, Bednarski PJ
BMC Complement Altern Med. 2009;9(0):7.
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| 24. | Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity. Frank MB, Yang Q, Osban J, Azzarello JT, Saban MR, Saban R, Ashley RA, Welter JC, Fung KM, Lin HK
BMC Complement Altern Med. 2009;9(0):6.
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| 25. | In vitro screening for the tumoricidal properties of international medicinal herbs. Mazzio EA, Soliman KF
Phytother Res. 2009 Mar;23(3):385-98.
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| 26. | Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1. Kunnumakkara AB, Nair AS, Sung B, Pandey MK, Aggarwal BB
Mol Cancer Res. 2009 Jan;7(1):118-28.
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| 27. | Bosellia serrata-induced apoptosis is related with ER stress and calcium release. Kim HR, Kim MS, Kwon DY, Chae SW, Chae HJ
Genes Nutr. 2008 Feb;2(4):371-4.
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| 28. | Inhibitory effect of acetyl-11-keto-beta-boswellic acid on androgen receptor by interference of Sp1 binding activity in prostate cancer cells. Yuan HQ, Kong F, Wang XL, Young CY, Hu XY, Lou HX
Biochem Pharmacol. 2008 Jun;75(11):2112-21.
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| 29. | Comparison of the irritation potentials of Boswellia serrata gum resin and of acetyl-11-keto-beta-boswellic acid by in vitro cytotoxicity tests on human skin-derived cell lines. Burlando B, Parodi A, Volante A, Bassi AM
Toxicol Lett. 2008 Mar;177(2):144-9.
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| 30. | Acetyl-keto-beta-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells. Lu M, Xia L, Hua H, Jing Y
Cancer Res. 2008 Feb;68(4):1180-6.
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| 31. | Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids. Shah BA, Kumar A, Gupta P, Sharma M, Sethi VK, Saxena AK, Singh J, Qazi GN, Taneja SC
Bioorg Med Chem Lett. 2007 Dec;17(23):6411-6.
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| 32. | A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells. Bhushan S, Kumar A, Malik F, Andotra SS, Sethi VK, Kaur IP, Taneja SC, Qazi GN, Singh J
Apoptosis. 2007 Oct;12(10):1911-26.
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| 33. | Effect of acetyl 11-keto beta-boswellic acid on metastatic growth factor responsible for angiogenesis. Singh SK, Bhusari S, Singh R, Saxena A, Mondhe D, Qazi GN
Vascul Pharmacol. 2007 May;46(5):333-7.
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| 34. | A lipoxygenase inhibitor in breast cancer brain metastases. Flavin DF
J Neurooncol. 2007 Mar;82(1):91-3.
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| 35. | Characterization of 3alpha-acetyl-11-keto-alpha-boswellic acid, a pentacyclic triterpenoid inducing apoptosis in vitro and in vivo. Büchele B, Zugmaier W, Estrada A, Genze F, Syrovets T, Paetz C, Schneider B, Simmet T
Planta Med. 2006 Nov;72(14):1285-9.
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| 36. | Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri. Akihisa T, Tabata K, Banno N, Tokuda H, Nishimura R, Nishihara R, Nakamura Y, Kimura Y, Yasukawa K, Suzuki T
Biol Pharm Bull. 2006 Sep;29(9):1976-9.
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| 37. | Acetyl-keto-beta-boswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells. Liu JJ, Huang B, Hooi SC
Br J Pharmacol. 2006 Aug;148(8):1099-107.
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| 38. | Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells. Xia L, Chen D, Han R, Fang Q, Waxman S, Jing Y
Mol Cancer Ther. 2005 Mar;4(3):381-8.
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| 39. | Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo. Syrovets T, Gschwend JE, Büchele B, Laumonnier Y, Zugmaier W, Genze F, Simmet T
J Biol Chem. 2005 Feb;280(7):6170-80.
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| 40. | Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase. Andersson D, Liu JJ, Nilsson A, Duan RD
Anticancer Res. 2003 Jul-Aug;23(4):3317-22.
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| 41. | Acetyl-11-keto-beta-boswellic acid (AKBA) is cytotoxic for meningioma cells and inhibits phosphorylation of the extracellular-signal regulated kinase 1 and 2. Park YS, Lee JH, Harwalkar JA, Bondar J, Safayhi H, Golubic M
Adv Exp Med Biol. 2002;507(0):387-93.
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| 42. | Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells. Zhao W, Entschladen F, Liu H, Niggemann B, Fang Q, Zaenker KS, Han R
Cancer Detect Prev. 2003;27(1):67-75.
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| 43. | Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro. Hostanska K, Daum G, Saller R
Anticancer Res. 2002 Sep-Oct;22(5):2853-62.
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| 44. | Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Liu JJ, Nilsson A, Oredsson S, Badmaev V, Zhao WZ, Duan RD
Carcinogenesis. 2002 Dec;23(12):2087-93.
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| 45. | Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway. Liu JJ, Nilsson A, Oredsson S, Badmaev V, Duan RD
Int J Mol Med. 2002 Oct;10(4):501-5.
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| 46. | [Experimental study on Jurkat cell apoptosis induced by Boswellia carterii Birdw extractive]. Liu X, Qi ZH
Hunan Yi Ke Da Xue Xue Bao. 2000 Jun;25(3):241-4.
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| 47. | Cytotoxic action of acetyl-11-keto-beta-boswellic acid (AKBA) on meningioma cells. Park YS, Lee JH, Bondar J, Harwalkar JA, Safayhi H, Golubic M
Planta Med. 2002 May;68(5):397-401.
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| 48. | [Experimental study on induction of apoptosis of leukemic cells by Boswellia carterii Birdw extractive]. Qi Z, Zhang G, Zhu W
Hunan Yi Ke Da Xue Xue Bao. 1999;24(1):23-5.
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| 49. | Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid. Huang MT, Badmaev V, Ding Y, Liu Y, Xie JG, Ho CT
Biofactors. 2000;13(1-4):225-30.
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| 50. | Boswellic acids inhibit glioma growth: a new treatment option? Winking M, Sarikaya S, Rahmanian A, Jödicke A, Böker DK
J Neurooncol. 2000;46(2):97-103.
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| 51. | Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity. Glaser T, Winter S, Groscurth P, Safayhi H, Sailer ER, Ammon HP, Schabet M, Weller M
Br J Cancer. 1999 May;80(5-6):756-65.
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| 52. | Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I. Hoernlein RF, Orlikowsky T, Zehrer C, Niethammer D, Sailer ER, Simmet T, Dannecker GE, Ammon HP
J Pharmacol Exp Ther. 1999 Feb;288(2):613-9.
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| 53. | Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines. Jing Y, Nakajo S, Xia L, Nakaya K, Fang Q, Waxman S, Han R
Leuk Res. 1999 Jan;23(1):43-50.
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| 54. | Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture. Shao Y, Ho CT, Chin CK, Badmaev V, Ma W, Huang MT
Planta Med. 1998 May;64(4):328-31.
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| 55. | Recent progress in the study of anticancer drugs originating from plants and traditional medicines in China. Han R
Chin Med Sci J. 1994 Mar;9(1):61-9.
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| 56. | Highlight on the studies of anticancer drugs derived from plants in China. Han R
Stem Cells. 1994 Jan;12(1):53-63.
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| 57. | [Combination induction of cell differentiation of HL-60 cells by daidzein (S86019) and BC-4 or Ara-C]. Jing YK, Han R
Yao Xue Xue Bao. 1993;28(1):11-6.
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| 58. | Growth inhibition and differentiation of promyelocytic cells (HL-60) induced by BC-4, an active principle from Boswellia carterii Birdw. Jing Y, Xia L, Han R
Chin Med Sci J. 1992 Mar;7(1):12-5.
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