8.1.1 Entzündungsfaktoren-Mechanismen

Erste Untersuchungen mit einem Extrakt aus salai guggal und Boswelliasäuren auf Entzündungsfaktoren aus der Acharidonsäurekaskade und andere Entzündungsfaktoren wurden am Lehrstuhl Pharmakologie des Pharmazeutischen Instituts der Universität Tübingen nach einem Treffen mit Dr. G.B. Sing aus Jammu (Indien) durchgeführt.




In vitro effects of an alcoholic extract from gum resin of Boswellia serrata AKBA/KBA on formation of 5-LOX products and elastase activity from polymorphnuclear leucozytes (PMNL)

aus: Ammon et al. 1991 und Safayhi et al. 1992



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Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property.

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Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors.

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Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization.

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Stimulation of leukotriene synthesis in intact polymorphonuclear cells by the 5-lipoxygenase inhibitor 3-oxo-tirucallic acid.

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Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues.

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Concentration-dependent potentiating and inhibitory effects of Boswellia extracts on 5-lipoxygenase product formation in stimulated PMNL.

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Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity.

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Inhibition by boswellic acids of human leukocyte elastase.

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Structure-activity relationships of the nonredox-type non-competitive leukotriene biosynthesis inhibitor acetyl-11-keto-β-boswellic acid.

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Phytomedicine. 1996 May;3(1):71-2.
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Acetyl-11-keto-beta-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity.

Br J Pharmacol. 1996 Feb;117(4):615-8.
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Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid.

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Mechanism of antiinflammatory actions of curcumine and boswellic acids.

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Anti-inflammatory activity of resins from some species of the plant family Burseraceae.

Planta Med. 1993 Feb;59(1):12-6.
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A sensitive and relevant model for evaluating anti-inflammatory activity-papaya latex-induced rat paw inflammation.

J Pharmacol Toxicol Methods. 1992 Aug;28(1):15-9.
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Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.

J Pharmacol Exp Ther. 1992 Jun;261(3):1143-6.
PMID: 1602379 [PubMed - indexed for MEDLINE]


Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata.

Planta Med. 1991 Jun;57(3):203-7.
PMID: 1654575 [PubMed - indexed for MEDLINE]


Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new non-steroidal anti-inflammatory agent.

Agents Actions. 1986 Jun;18(3-4):407-12.
PMID: 3751752 [PubMed - indexed for MEDLINE]