8.1.1 Entzündungsfaktoren-Mechanismen

Erste Untersuchungen mit einem Extrakt aus salai guggal und Boswelliasäuren auf Entzündungsfaktoren aus der Acharidonsäurekaskade und andere Entzündungsfaktoren wurden am Lehrstuhl Pharmakologie des Pharmazeutischen Instituts der Universität Tübingen nach einem Treffen mit Dr. G.B. Sing aus Jammu (Indien) durchgeführt.

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In vitro effects of an alcoholic extract from gum resin of Boswellia serrata AKBA/KBA on formation of 5-LOX products and elastase activity from polymorphnuclear leucozytes (PMNL)

aus: Ammon et al. 1991 und Safayhi et al. 1992

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Hier noch einige der wichtigsten Ergebnisse unseres Instituts:

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Publikationen

1. Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-β-boswellic acid in combination on isoproterenol-induced myocardial injury in rats.
Chen M, Wang M, Yang Q, Wang M, Wang Z, Zhu Y, Zhang Y, Wang C, Jia Y, Li Y, Wen A

Int J Mol Med. 2016 Jun;37(6):1501-10.
PMID: 27121241 [PubMed - as supplied by publisher]

2. Enhanced Neuroprotection of Acetyl-11-Keto-β-Boswellic Acid (AKBA)-Loaded O-Carboxymethyl Chitosan Nanoparticles Through Antioxidant and Anti-Inflammatory Pathways.
Ding Y, Qiao Y, Wang M, Zhang H, Li L, Zhang Y, Ge J, Song Y, Li Y, Wen A

Mol Neurobiol. 2016 Aug;53(6):3842-53.
PMID: 26162321 [PubMed - as supplied by publisher]

3. Synthesis and biological evaluation of boswellic acid-NSAID hybrid molecules as anti-inflammatory and anti-arthritic agents.
Shenvi S, Kiran KR, Kumar K, Diwakar L, Reddy GC

Eur J Med Chem. 2015 Jun;98(0):170-8.
PMID: 26010018 [PubMed - indexed for MEDLINE]

4. Antioxidant and hepatoprotective effects of Boswellia ovalifoliolata bark extracts.
Mahesh BU, Shrivastava S, Pragada RR, Naidu VG, Sistla R

Chin J Nat Med. 2014 Sep;12(9):663-71.
PMID: 25263977 [PubMed - indexed for MEDLINE]

5. Cardioprotective and antioxidant effects of oleogum resin "Olibanum" from Bos Boswellia carteri Birdw. (Bursearceae).
Zaki AA, Hashish NE, Amer MA, Lahloub MF

Chin J Nat Med. 2014 May;12(5):345-50.
PMID: 24856757 [PubMed - indexed for MEDLINE]

6. Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1.
Verhoff M, Seitz S, Paul M, Noha SM, Jauch J, Schuster D, Werz O

J Nat Prod. 2014 Jun;77(6):1445-51.
PMID: 24844534 [PubMed - indexed for MEDLINE]

7. Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis.
Umar S, Umar K, Sarwar AH, Khan A, Ahmad N, Ahmad S, Katiyar CK, Husain SA, Khan HA

Phytomedicine. 2014 May;21(6):847-56.
PMID: 24667331 [PubMed - indexed for MEDLINE]

8. Boswellia serrata has beneficial anti-inflammatory and antioxidant properties in a model of experimental colitis.
Hartmann RM, Fillmann HS, Martins MI, Meurer L, Marroni NP

Phytother Res. 2014 Sep;28(9):1392-8.
PMID: 24619538 [PubMed - indexed for MEDLINE]

9. Major constituents of Boswellia carteri resin exhibit cyclooxygenase enzyme inhibition and antiproliferative activity.
Ali SI, Zhang CR, Mohamed AA, El-Baz FK, Hegazy AK, Kord MA, Nair MG

Nat Prod Commun. 2013 Oct;8(10):1365-6.
PMID: 24354175 [PubMed - indexed for MEDLINE]

10. The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys.
Azemi ME, Namjoyan F, Khodayar MJ, Ahmadpour F, Darvish Padok A, Panahi M

Jundishapur J Nat Pharm Prod. 2012;7(4):168-75.
PMID: 24624177 [PubMed - as supplied by publisher]

11. A novel C(28)-hydroxylated lupeolic acid suppresses the biosynthesis of eicosanoids through inhibition of cytosolic phospholipase A(2).
Verhoff M, Seitz S, Northoff H, Jauch J, Schaible AM, Werz O

Biochem Pharmacol. 2012 Sep;84(5):681-91.
PMID: 22732453 [PubMed - indexed for MEDLINE]

12. Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii.
Su S, Hua Y, Wang Y, Gu W, Zhou W, Duan JA, Jiang H, Chen T, Tang Y

J Ethnopharmacol. 2012 Jan;139(2):649-56.
PMID: 22178177 [PubMed - indexed for MEDLINE]

13. Boswellic acids from frankincense inhibit lipopolysaccharide functionality through direct molecular interference.
Henkel A, Kather N, Mönch B, Northoff H, Jauch J, Werz O

Biochem Pharmacol. 2012 Jan;83(1):115-21.
PMID: 22001311 [PubMed - indexed for MEDLINE]

14. Anti-inflammatory, antinociceptive and antioxidant activities of the endemic Soqotraen Boswellia elongata Balf. f. and Jatropha unicostata Balf. f. in different experimental models.
Mothana RA

Food Chem Toxicol. 2011 Oct;49(10):2594-9.
PMID: 21777643 [PubMed - indexed for MEDLINE]

15. Growth inhibitory, apoptotic and anti-inflammatory activities displayed by a novel modified triterpenoid, cyano enone of methyl boswellates.
Ravanan P, Singh SK, Rao GS, Kondaiah P

J Biosci. 2011 Jun;36(2):297-307.
PMID: 21654084 [PubMed - indexed for MEDLINE]

16. Inhibition of microsomal prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense.
Siemoneit U, Koeberle A, Rossi A, Dehm F, Verhoff M, Reckel S, Maier TJ, Jauch J, Northoff H, Bernhard F, Doetsch V, Sautebin L, Werz O

Br J Pharmacol. 2011 Jan;162(1):147-62.
PMID: 20840544 [PubMed - indexed for MEDLINE]

17. Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.
Cao H, Yu R, Choi Y, Ma ZZ, Zhang H, Xiang W, Lee DY, Berman BM, Moudgil KD, Fong HH, van Breemen RB

Pharmacol Res. 2010 Jun;61(6):519-24.
PMID: 20188172 [PubMed - indexed for MEDLINE]

18. Comparative study of the chemical composition and antioxidant activity of six essential oils and their components.
Yang SA, Jeon SK, Lee EJ, Shim CH, Lee IS

Nat Prod Res. 2010;24(2):140-51.
PMID: 20077307 [PubMed - indexed for MEDLINE]

19. Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage.
Blain EJ, Ali AY, Duance VC

Phytother Res. 2010 Jun;24(6):905-12.
PMID: 19943332 [PubMed - indexed for MEDLINE]

20. Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense.
Tausch L, Henkel A, Siemoneit U, Poeckel D, Kather N, Franke L, Hofmann B, Schneider G, Angioni C, Geisslinger G, Skarke C, Holtmeier W, Beckhaus T, Karas M, Jauch J, Werz O

J Immunol. 2009 Sep;183(5):3433-42.
PMID: 19648270 [PubMed - indexed for MEDLINE]

21. On the interference of boswellic acids with 5-lipoxygenase: mechanistic studies in vitro and pharmacological relevance.
Siemoneit U, Pergola C, Jazzar B, Northoff H, Skarke C, Jauch J, Werz O

Eur J Pharmacol. 2009 Mar;606(1-3):246-54.
PMID: 19374837 [PubMed - indexed for MEDLINE]

22. Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island Soqotra.
Mothana RA, Lindequist U, Gruenert R, Bednarski PJ

BMC Complement Altern Med. 2009;9(0):7.
PMID: 19320966 [PubMed - indexed for MEDLINE]

23. Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids.
Siemoneit U, Hofmann B, Kather N, Lamkemeyer T, Madlung J, Franke L, Schneider G, Jauch J, Poeckel D, Werz O

Biochem Pharmacol. 2008 Jan;75(2):503-13.
PMID: 17945191 [PubMed - indexed for MEDLINE]

24. Boswellic acids stimulate arachidonic acid release and 12-lipoxygenase activity in human platelets independent of Ca2+ and differentially interact with platelet-type 12-lipoxygenase.
Poeckel D, Tausch L, Kather N, Jauch J, Werz O

Mol Pharmacol. 2006 Sep;70(3):1071-8.
PMID: 16788089 [PubMed - indexed for MEDLINE]

25. 3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells.
Poeckel D, Tausch L, George S, Jauch J, Werz O

J Pharmacol Exp Ther. 2006 Jan;316(1):224-32.
PMID: 16174802 [PubMed - indexed for MEDLINE]

26. Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid.
Poeckel D, Tausch L, Altmann A, Feisst C, Klinkhardt U, Graff J, Harder S, Werz O

Br J Pharmacol. 2005 Oct;146(4):514-24.
PMID: 16086030 [PubMed - indexed for MEDLINE]

27. Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property.
Pandey RS, Singh BK, Tripathi YB

Indian J Exp Biol. 2005 Jun;43(6):509-16.
PMID: 15991575 [PubMed - indexed for MEDLINE]

28. Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats.
Fan AY, Lao L, Zhang RX, Zhou AN, Wang LB, Moudgil KD, Lee DY, Ma ZZ, Zhang WY, Berman BM

J Ethnopharmacol. 2005 Oct;101(1-3):104-9.
PMID: 15970410 [PubMed - indexed for MEDLINE]

29. Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes.
Altmann A, Poeckel D, Fischer L, Schubert-Zsilavecz M, Steinhilber D, Werz O

Br J Pharmacol. 2004 Jan;141(2):223-32.
PMID: 14691050 [PubMed - indexed for MEDLINE]

30. Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors.
Fischer L, Szellas D, Rådmark O, Steinhilber D, Werz O

FASEB J. 2003 May;17(8):949-51.
PMID: 12670876 [PubMed - indexed for MEDLINE]

31. Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization.
Altmann A, Fischer L, Schubert-Zsilavecz M, Steinhilber D, Werz O

Biochem Biophys Res Commun. 2002 Jan;290(1):185-90.
PMID: 11779151 [PubMed - indexed for MEDLINE]

32. Stimulation of leukotriene synthesis in intact polymorphonuclear cells by the 5-lipoxygenase inhibitor 3-oxo-tirucallic acid.
Boden SE, Schweizer S, Bertsche T, Düfer M, Drews G, Safayhi H

Mol Pharmacol. 2001 Aug;60(2):267-73.
PMID: 11455013 [PubMed - indexed for MEDLINE]

33. Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues.
Schweizer S, von Brocke AF, Boden SE, Bayer E, Ammon HP, Safayhi H

J Nat Prod. 2000 Aug;63(8):1058-61.
PMID: 10978197 [PubMed - indexed for MEDLINE]

34. Concentration-dependent potentiating and inhibitory effects of Boswellia extracts on 5-lipoxygenase product formation in stimulated PMNL.
Safayhi H, Boden SE, Schweizer S, Ammon HP

Planta Med. 2000 Mar;66(2):110-3.
PMID: 10763581 [PubMed - indexed for MEDLINE]

35. Characterization of an acetyl-11-keto-beta-boswellic acid and arachidonate-binding regulatory site of 5-lipoxygenase using photoaffinity labeling.
Sailer ER, Schweizer S, Boden SE, Ammon HP, Safayhi H

Eur J Biochem. 1998 Sep;256(2):364-8.
PMID: 9760176 [PubMed - indexed for MEDLINE]

36. Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity.
Werz O, Szellas D, Henseler M, Steinhilber D

Mol Pharmacol. 1998 Aug;54(2):445-51.
PMID: 9687587 [PubMed - indexed for MEDLINE]

37. Inhibition by boswellic acids of human leukocyte elastase.
Safayhi H, Rall B, Sailer ER, Ammon HP

J Pharmacol Exp Ther. 1997 Apr;281(1):460-3.
PMID: 9103531 [PubMed - indexed for MEDLINE]

38. Acetyl-11-keto-beta-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity.
Sailer ER, Subramanian LR, Rall B, Hoernlein RF, Ammon HP, Safayhi H

Br J Pharmacol. 1996 Feb;117(4):615-8.
PMID: 8646405 [PubMed - indexed for MEDLINE]

39. Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid.
Safayhi H, Sailer ER, Ammon HP

Mol Pharmacol. 1995 Jun;47(6):1212-6.
PMID: 7603462 [PubMed - indexed for MEDLINE]

40. Mechanism of antiinflammatory actions of curcumine and boswellic acids.
Ammon HP, Safayhi H, Mack T, Sabieraj J

J Ethnopharmacol. 1993 Mar;38(2-3):113-9.
PMID: 8510458 [PubMed - indexed for MEDLINE]

41. Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.
Safayhi H, Mack T, Sabieraj J, Anazodo MI, Subramanian LR, Ammon HP

J Pharmacol Exp Ther. 1992 Jun;261(3):1143-6.
PMID: 1602379 [PubMed - indexed for MEDLINE]

42. Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata.
Ammon HP, Mack T, Singh GB, Safayhi H

Planta Med. 1991 Jun;57(3):203-7.
PMID: 1654575 [PubMed - indexed for MEDLINE]