8.1.2 Faktoren des Immunsystem

Es ist offenbar, dass wohl im Wesentlichen Teile des Immunsystems, die an Autoimmunerkrankungen beteiligt sind, als Ziel der Wirkung von Boswelliasäuren infrage kommen.



Acetyl-11-Keto-β-Boswellic Acid Promotes Osteoblast Differentiation by Inhibiting Tumor Necrosis Factor-α and Nuclear Factor-κB Activity.

J Craniofac Surg. 2018 Oct;29(7):1996-2002.
PMID: 29927820 [PubMed - as supplied by publisher]


Acetyl-11-keto-β-boswellic acid inhibits the secretion of cytokines by dendritic cells via the TLR7/8 pathway in an imiquimod-induced psoriasis mouse model and in vitro.

Life Sci. 2018 Aug;207():90-104.
PMID: 29859222 [PubMed - indexed for MEDLINE]


Herbal Products for Common Auto-Inflammatory Disorders - Novel Approaches.

Comb Chem High Throughput Screen. 2018;21(3):161-174.
PMID: 29436996 [PubMed - as supplied by publisher]


The major Boswellia serrata active 3-acetyl-11-keto-β-boswellic acid strengthens interleukin-1α upregulation of matrix metalloproteinase-9 via JNK MAP kinase activation.

Phytomedicine. 2017 Dec;36():176-182.
PMID: 29157812 [PubMed - indexed for MEDLINE]


Antioxidant and Immune System Regulatory Properties of Extracts.

Oxid Med Cell Longev. 2017;2017():7468064.
PMID: 28386311 [PubMed - indexed for MEDLINE]


Analogues of boswellic acids as inhibitors of pro-inflammatory cytokines TNF-α and IL-6.

Bioorg Med Chem Lett. 2016 Jan;26(2):695-698.
PMID: 26711891 [PubMed - indexed for MEDLINE]


Boswellic acids target the human immune system-modulating antimicrobial peptide LL-37.

Pharmacol Res. 2015 Dec;102():53-60.
PMID: 26361729 [PubMed - indexed for MEDLINE]


Comparative anti-inflammatory effects of anti-arthritic herbal medicines and ibuprofen.

Nat Prod Commun. 2014 Sep;9(9):1351-6.
PMID: 25918809 [PubMed - indexed for MEDLINE]


Inhibition of LPS-induced TNF-α and NO production in mouse macrophage and inflammatory response in rat animal models by a novel Ayurvedic formulation, BV-9238.

Phytother Res. 2014 Oct;28(10):1479-85.
PMID: 24706581 [PubMed - indexed for MEDLINE]


Extract from gum resin of Boswellia serrata decreases IA(2)-antibody in a patient with "Late onset Autoimmune Diabetes of the Adult" (LADA).

Phytomedicine. 2014 May;21(6):786.
PMID: 24698440 [PubMed - indexed for MEDLINE]


Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis.

Phytomedicine. 2014 May;21(6):847-56.
PMID: 24667331 [PubMed - indexed for MEDLINE]


Boswellic acids reduce Th17 differentiation via blockade of IL-1β-mediated IRAK1 signaling.

Eur J Immunol. 2014 Apr;44(4):1200-12.
PMID: 24469975 [PubMed - indexed for MEDLINE]


[Change in dissolution of chemical components of frankincense-myrrh before and after their compatibility and effect on no release of LPS-induced macrophage cells].

Zhongguo Zhong Yao Za Zhi. 2013 Jan;38(2):179-85.
PMID: 23672038 [PubMed - indexed for MEDLINE]


Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105.

Pharmacogn Mag. 2013 Jan;9(33):51-7.
PMID: 23661994 [PubMed - as supplied by publisher]


NF-κB down-regulation and PARP cleavage by novel 3-α-butyryloxy-β-boswellic acid results in cancer cell specific apoptosis and in vivo tumor regression.

Anticancer Agents Med Chem. 2013 Jun;13(5):777-90.
PMID: 23157593 [PubMed - indexed for MEDLINE]


Efficacy of boswellic acid on lysosomal acid hydrolases, lipid peroxidation and anti-oxidant status in gouty arthritic mice.

Asian Pac J Trop Biomed. 2012 Feb;2(2):128-33.
PMID: 23569882 [PubMed - indexed for MEDLINE]


Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs.

Bioorg Med Chem Lett. 2012 Jan;22(1):431-5.
PMID: 22123322 [PubMed - indexed for MEDLINE]


Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes.

BMC Complement Altern Med. 2011 Aug;11():66.
PMID: 21854562 [PubMed - indexed for MEDLINE]


Gum resin of Boswellia serrata inhibited human monocytic (THP-1) cell activation and platelet aggregation.

J Ethnopharmacol. 2011 Sep;137(1):893-901.
PMID: 21771654 [PubMed - indexed for MEDLINE]


Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract.

Mol Cell Biochem. 2011 Aug;354(1-2):189-97.
PMID: 21479939 [PubMed - indexed for MEDLINE]


Immunological adjuvant effect of Boswellia serrata (BOS 2000) on specific antibody and cellular response to ovalbumin in mice.

Int Immunopharmacol. 2011 Aug;11(8):968-75.
PMID: 21371582 [PubMed - indexed for MEDLINE]


Traditional herbal remedies that influence cell adhesion molecule activity.

Phytother Res. 2011 Apr;25(4):473-83.
PMID: 21105177 [PubMed - indexed for MEDLINE]


Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage.

Phytother Res. 2010 Jun;24(6):905-12.
PMID: 19943332 [PubMed - indexed for MEDLINE]


Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis.

J Immunol. 2009 Oct;183(7):4755-63.
PMID: 19752240 [PubMed - indexed for MEDLINE]


Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity.

Tetrahedron. 2008 Dec;64(51):11541-11548.
PMID: 20622928 [PubMed - as supplied by publisher]


Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration.

J Leukoc Biol. 2008 Jul;84(1):215-23.
PMID: 18436581 [PubMed - indexed for MEDLINE]


Immunomodulatory activity of biopolymeric fraction BOS 2000 from Boswellia serrata.

Phytother Res. 2008 Mar;22(3):340-8.
PMID: 18167047 [PubMed - indexed for MEDLINE]


Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice.

Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):272-7.
PMID: 18032778 [PubMed - indexed for MEDLINE]


Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation.

Mol Pharmacol. 2007 Dec;72(6):1657-64.
PMID: 17895408 [PubMed - indexed for MEDLINE]


A new vaccine adjuvant (BOS 2000) a potent enhancer mixed Th1/Th2 immune responses in mice immunized with HBsAg.

Vaccine. 2007 Jun;25(23):4586-94.
PMID: 17498851 [PubMed - indexed for MEDLINE]


Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFalpha, IL-1beta, NO and MAP kinases.

Int Immunopharmacol. 2007 Apr;7(4):473-82.
PMID: 17321470 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.

J Immunol. 2006 Mar;176(5):3127-40.
PMID: 16493072 [PubMed - indexed for MEDLINE]


Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property.

Indian J Exp Biol. 2005 Jun;43(6):509-16.
PMID: 15991575 [PubMed - indexed for MEDLINE]


Boswellia carterii extract inhibits TH1 cytokines and promotes TH2 cytokines in vitro.

Clin Diagn Lab Immunol. 2005 May;12(5):575-80.
PMID: 15879017 [PubMed - indexed for MEDLINE]


Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells.

DNA Cell Biol. 2005 Apr;24(4):244-55.
PMID: 15812241 [PubMed - indexed for MEDLINE]


Acetyl-boswellic acids inhibit lipopolysaccharide-mediated TNF-alpha induction in monocytes by direct interaction with IkappaB kinases.

J Immunol. 2005 Jan;174(1):498-506.
PMID: 15611276 [PubMed - indexed for MEDLINE]


Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb.

Indian J Exp Biol. 2003 Dec;41(12):1460-2.
PMID: 15320503 [PubMed - indexed for MEDLINE]


Immunomodulatory triterpenoids from the oleogum resin of Boswellia carterii Birdwood.

Z Naturforsch C. 2003 Jul-Aug;58(7-8):505-16.
PMID: 12939036 [PubMed - indexed for MEDLINE]


Chemistry and immunomodulatory activity of frankincense oil.

Z Naturforsch C. 2003 Mar-Apr;58(3-4):230-8.
PMID: 12710734 [PubMed - indexed for MEDLINE]


Boswellic acid, a potent antiinflammatory drug, inhibits rejection to the same extent as high dose steroids.

Transplant Proc. 2001 Feb-Mar;33(1-2):539-41.
PMID: 11266947 [PubMed - indexed for MEDLINE]


Effects of boswellic acid of Boswellia serrata and other triterpenic acids on the complement system.

Phytomedicine. 1996 May;3(1):77-80.
PMID: 23194867 [PubMed - as supplied by publisher]


Anticomplementary activity of boswellic acids--an inhibitor of C3-convertase of the classical complement pathway.

Int J Immunopharmacol. 1992 Oct;14(7):1139-43.
PMID: 1452399 [PubMed - indexed for MEDLINE]


Effect of salai guggal ex-Boswellia serrata on cellular and humoral immune responses and leucocyte migration.

Agents Actions. 1988 Jun;24(1-2):161-4.
PMID: 3407547 [PubMed - indexed for MEDLINE]