8.1.2 Faktoren des Immunsystem

Es ist offenbar, dass wohl im Wesentlichen Teile des Immunsystems, die an Autoimmunerkrankungen beteiligt sind, als Ziel der Wirkung von Boswelliasäuren infrage kommen.



Antioxidant and anti-inflammatory effects of and extracts in alloxan-induced diabetic rats.
Hamadjida A, Mbomo REA, Minko SE, Ntchapda F, Kilekoung Mingoas JP, Nnanga N

Metabol Open. 2024 Mar;21():100278.
PMID: 38455229 [PubMed - as supplied by publisher]


Acetyl-11-keto-beta-boswellic acid modulates macrophage polarization and Schwann cell migration to accelerate spinal cord injury repair in rats.
Wang Y, Xiong Z, Qiao Y, Zhang Q, Zhou G, Zhou C, Ma X, Jiang X, Yu W

CNS Neurosci Ther. 2024 Mar;30(3):e14642.
PMID: 38430464 [PubMed - indexed for MEDLINE]


Immunomodulatory Role of Plants and Their Constituents on the Management of Metabolic Disorders: An Evidence-Based Review.
Febriyanti RM, Levita J, Diantini A

Drug Des Devel Ther. 2024;18():513-534.
PMID: 38415194 [PubMed - indexed for MEDLINE]


Frankincense preparation promotes formation of inflammation-resolving lipid mediators by manipulating lipoxygenases in human innate immune cells.
Nischang V, Witt FM, Börner F, Gomez M, Jordan PM, Werz O

Front Pharmacol. 2023;14():1332628.
PMID: 38239198 [PubMed - as supplied by publisher]


WGA-M001, a Mixture of Total Extracts of and , Synergistically Alleviates Cartilage Destruction by Inhibiting ERK and NF-κB Signaling.
Oh E, Jang H, Ok S, Eom J, Lee H, Kim SH, Kim JH, Jeong YM, Kim KJ, Yun SP, Kwon HJ, Lee IC, Park JY, Yang S

Int J Mol Sci. 2023 Dec;24(24):.
PMID: 38139287 [PubMed - indexed for MEDLINE]


Extracts Ameliorates Symptom of Irregularities in Articular Cartilage through Inhibition of Matrix Metalloproteinases Activation and Apoptosis in Monosodium-Iodoacetate-Induced Osteoarthritic Rat Models.
Kim J, Eun S, Jung H, Kim J, Kim J

Prev Nutr Food Sci. 2023 Sep;28(3):285-292.
PMID: 37842260 [PubMed - as supplied by publisher]


Repurposing of known drugs for COVID-19 using molecular docking and simulation analysis.
Bhanu P, Setlur AS, K C, Niranjan V, Hemandhar Kumar N, Buchke S, Kumar J, Rani A, Tiwari SM, Mishra V

Bioinformation. 2023;19(2):149-159.
PMID: 37814677 [PubMed - as supplied by publisher]


CKBA suppresses mast cell activation via ERK signaling pathway in murine atopic dermatitis.
Tong J, Li Y, Cai X, Lou F, Sun Y, Wang Z, Zheng X, Zhou H, Zhang Z, Fang Z, Ding W, Deng S, Xu Z, Niu X, Wang H

Eur J Immunol. 2023 Sep;53(9):e2350374.
PMID: 37417726 [PubMed - indexed for MEDLINE]


Acetyl-11-Keto-Beta-Boswellic Acid Has Therapeutic Benefits for NAFLD Rat Models That Were Given a High Fructose Diet by Ameliorating Hepatic Inflammation and Lipid Metabolism.
Kachouei RA, Doagoo A, Jalilzadeh M, Khatami SH, Rajaei S, Jahan-Abad AJ, Salmani F, Pakrad R, Baram SM, Nourbakhsh M, Abdollahifar MA, Abbaszadeh HA, Noori S, Rezaei M, Mahdavi M, Shahmohammadi MR, Karima S

Inflammation. 2023 Oct;46(5):1966-1980.
PMID: 37310644 [PubMed - indexed for MEDLINE]


Correction to: Pro-infammatory cytokine molecules from Boswellia serrate suppresses lipopolysaccharides induced infammation demonstrated in an in-vivo zebrafsh larval model.
Siddhu NSS, Guru A, Kumar RCS, Almutairi BO, Almutairi MH, Juliet A, Vijayakumar TM, Arockiaraj J

Mol Biol Rep. 2023 Jul;50(7):6307.
PMID: 37289364 [PubMed - as supplied by publisher]


Dietary Frankincense () Oil Modulates the Growth, Intestinal Morphology, the Fatty Acid Composition of Breast Muscle, Immune Status, and Immunoexpression of CD3 and CD20 in Broiler Chickens.
Amer SA, Gouda A, Saleh GK, Nassar AH, Abdel-Warith AA, Younis EM, Altohamy DE, Kilany MS, Davies SJ, Omar AE

Animals (Basel). 2023 Mar;13(6):.
PMID: 36978513 [PubMed - as supplied by publisher]


β Boswellic Acid Blocks Articular Innate Immune Responses: An In Silico and In Vitro Approach to Traditional Medicine.
Franco-Trepat E, Alonso-Pérez A, Guillán-Fresco M, López-Fagúndez M, Pazos-Pérez A, Crespo-Golmar A, Belén Bravo S, López-López V, Jorge-Mora A, Cerón-Carrasco JP, Lois Iglesias A, Gómez R

Antioxidants (Basel). 2023 Feb;12(2):.
PMID: 36829930 [PubMed - as supplied by publisher]


New verticillane-diterpenoid as potent NF-κB inhibitor isolated from the gum resin of Boswellia sacra.
Yuan Z, Liu D, Zhang B, Cao S, Yao T, Zhao Q, Qiu F, Zhao F

Fitoterapia. 2023 Apr;166():105460.
PMID: 36801349 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic Acid Confers Protection in DSS-Induced Colitis via the JNK-p38 MAPK and NF-κB Signaling Pathways.
Zhang P, Jiang H

Adv Biol (Weinh). 2023 Jun;7(6):e2200247.
PMID: 36658725 [PubMed - indexed for MEDLINE]


Boswellic acid coated zinc nanoparticles attenuate NF-κB-mediated inflammation in DSS-induced ulcerative colitis in rats.
Abou Zaid ES, Mansour SZ, El-Sonbaty SM, Moawed FS, Kandil EI, Haroun RA

Int J Immunopathol Pharmacol. 2023;37():3946320221150720.
PMID: 36600460 [PubMed - indexed for MEDLINE]


Protective Mechanisms of 3-Acetyl-11-keto-β-Boswellic Acid and Piperine in Fluid Percussion Rat Model of Traumatic Brain Injury Targeting Nrf2 and NFkB Signaling.
Kundu S, Singh S

Neurotox Res. 2023 Feb;41(1):57-84.
PMID: 36576717 [PubMed - indexed for MEDLINE]


Beta-Boswellic Acid Reverses 3-Nitropropionic Acid-Induced Molecular, Mitochondrial, and Histopathological Defects in Experimental Rat Model of Huntington's Disease.
Albekairi TH, Kamra A, Bhardwaj S, Mehan S, Giri A, Suri M, Alshammari A, Alharbi M, Alasmari AF, Narula AS, Kalfin R

Biomedicines. 2022 Nov;10(11):.
PMID: 36359390 [PubMed - as supplied by publisher]


Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II).
Mioc M, Prodea A, Racoviceanu R, Mioc A, Ghiulai R, Milan A, Voicu M, Mardale G, Șoica C

Int J Mol Sci. 2022 Aug;23(16):.
PMID: 36012159 [PubMed - indexed for MEDLINE]


Protective effect of a novel polyherbal formulation on experimentally induced osteoarthritis in a rat model.
Orhan C, Tuzcu M, Durmus AS, Sahin N, Ozercan IH, Deeh PBD, Morde A, Bhanuse P, Acharya M, Padigaru M, Sahin K

Biomed Pharmacother. 2022 Jul;151():113052.
PMID: 35588576 [PubMed - indexed for MEDLINE]


Isolation, molecular characterization, immunological and anticoagulatant activities of polysaccharides from frankincense and its vinegar processed product.
Guo JY, Song XR, Wang YN, Hua HM, Ren SM, Pan YN, Ren K, Sun YF, Wang DM, Liu XQ

Food Chem. 2022 Sep;389():133067.
PMID: 35490520 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid improves clinical symptoms through modulation of Nrf2 and NF-κB pathways in SJL/J mouse model of experimental autoimmune encephalomyelitis.
Nadeem A, Ahmad SF, Al-Harbi NO, Sarawi W, Attia SM, Alanazi WA, Ibrahim KE, Alsanea S, Alqarni SA, Alfardan AS, Bakheet SA

Int Immunopharmacol. 2022 Jun;107():108703.
PMID: 35306283 [PubMed - indexed for MEDLINE]


Inflawell improves neutrophil-to-lymphocyte ratio and shortens hospitalization in patients with moderate COVID-19, in a randomized double-blind placebo-controlled clinical trial.
Barzin Tond S, Balenci L, Khajavirad N, Salehi M, Tafakhori A, Shahmohammadi MR, Ghiasvand F, Jafari S, Abolghasemi S, Mokhtari F, Mahmoodi Baram S, Zarei T, Kazemi D, Mohammadnejad E, Shah-Hosseini A, Haghbin Toutounchi A, Fallah S, Riazi A, Karima S

Inflammopharmacology. 2022 Apr;30(2):465-475.
PMID: 35201518 [PubMed - indexed for MEDLINE]


Immunomodulatory properties of triterpenes.
Renda G, Gökkaya İ, Şöhretoğlu D

Phytochem Rev. 2022;21(2):537-563.
PMID: 34812259 [PubMed - as supplied by publisher]


Extract Containing 30% 3-Acetyl-11-Keto-Boswellic Acid Attenuates Inflammatory Mediators and Preserves Extracellular Matrix in Collagen-Induced Arthritis.
Majeed M, Nagabhushanam K, Lawrence L, Nallathambi R, Thiyagarajan V, Mundkur L

Front Physiol. 2021;12():735247.
PMID: 34650445 [PubMed - as supplied by publisher]


β-Boswellic Acid Inhibits RANKL-Induced Osteoclast Differentiation and Function by Attenuating NF-κB and Btk-PLCγ2 Signaling Pathways.
Park GD, Cheon YH, Eun SY, Lee CH, Lee MS, Kim JY, Cho HJ

Molecules. 2021 May;26(9):.
PMID: 34062884 [PubMed - indexed for MEDLINE]


Resin Extract in Diets of Nile Tilapia, : Effects on the Growth, Health, Immune Response, and Disease Resistance to .
Montaser MM, El-Sharnouby ME, El-Noubi G, El-Shaer HM, Khalil AA, Hassanin M, Amer SA, El-Araby DA

Animals (Basel). 2021 Feb;11(2):.
PMID: 33567795 [PubMed - as supplied by publisher]


SZB120 Exhibits Immunomodulatory Effects by Targeting eIF2α to Suppress Th17 Cell Differentiation.
Chen L, Bai J, Peng D, Gao Y, Cai X, Zhang J, Tang S, Niu L, Sun Y, Lou F, Zhou H, Yin Q, Wang Z, Sun L, Du X, Xu Z, Wang H, Li Q, Wang H

J Immunol. 2021 Mar;206(5):953-962.
PMID: 33483349 [PubMed - indexed for MEDLINE]


Effect of species on the metabolic syndrome: A review.
Mahdian D, Abbaszadeh-Goudarzi K, Raoofi A, Dadashizadeh G, Abroudi M, Zarepour E, Hosseinzadeh H

Iran J Basic Med Sci. 2020 Nov;23(11):1374-1381.
PMID: 33235693 [PubMed - as supplied by publisher]


Evaluation of immunomodulatory effects of Boswellia sacra essential oil on T-cells and dendritic cells.
Aldahlawi AM, Alzahrani AT, Elshal MF

BMC Complement Med Ther. 2020 Nov;20(1):352.
PMID: 33213426 [PubMed - indexed for MEDLINE]


The Beneficial Effect of Boswellic Acid on Bone Metabolism and Possible Mechanisms of Action in Experimental Osteoporosis.
Al-Dhubiab BE, Patel SS, Morsy MA, Duvva H, Nair AB, Deb PK, Shah J

Nutrients. 2020 Oct;12(10):.
PMID: 33081068 [PubMed - indexed for MEDLINE]


Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway.
Ju L, Hu P, Chen P, Xue X, Li Z, He F, Qiu Z, Cheng J, Huang F

Biomed Pharmacother. 2020 Sep;129():110471.
PMID: 32768958 [PubMed - indexed for MEDLINE]


Boswellia carteri extract and 3-O-acetyl-alpha-boswellic acid suppress T cell function.
Zimmermann-Klemd AM, Reinhardt JK, Nilsu T, Morath A, Falanga CM, Schamel WW, Huber R, Hamburger M, Gründemann C

Fitoterapia. 2020 Oct;146():104694.
PMID: 32712132 [PubMed - indexed for MEDLINE]


Acetyl-α-boswellic acid and Acetyl-β-boswellic acid protects against caerulein-induced pancreatitis via down-regulating MAPKs in mice.
Zhang PY, Yu B, Men WJ, Bai RY, Chen MY, Wang ZX, Zeng T, Zhou K

Int Immunopharmacol. 2020 Sep;86():106682.
PMID: 32563781 [PubMed - indexed for MEDLINE]


Double-blind trial of solid lipid Boswellia serrata particles (SLBSP) vs. standardized Boswellia serrata gum extract (BSE) for osteoarthritis of knee.
Kulkarni PD, Damle ND, Singh S, Yadav KS, Ghante MR, Bhaskar VH, Hingorani L, Gota VS

Drug Metab Pers Ther. 2020 Jun;35(2):.
PMID: 32549135 [PubMed - indexed for MEDLINE]


The effects of acetyl-11-keto-β-boswellic acid on brain cytokines and memory impairment induced by lipopolysaccharide in rats.
Marefati N, Beheshti F, Memarpour S, Bayat R, Naser Shafei M, Sadeghnia HR, Ghazavi H, Hosseini M

Cytokine. 2020 Jul;131():155107.
PMID: 32380425 [PubMed - indexed for MEDLINE]


Anti-osteoarthritic Effects of an Herbal Composition LI73014F2 on Interleukin-1β-induced Primary Human Articular Chondrocytes.
Kim HL, Lee HJ, Lee DR, Choi BK, Yang SH

Molecules. 2020 Apr;25(9):.
PMID: 32349389 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid ameliorates cognitive deficits and reduces amyloid-β levels in APPswe/PS1dE9 mice through antioxidant and anti-inflammatory pathways.
Wei C, Fan J, Sun X, Yao J, Guo Y, Zhou B, Shang Y

Free Radic Biol Med. 2020 Apr;150():96-108.
PMID: 32109514 [PubMed - indexed for MEDLINE]


Antioxidant, anti-inflammatory and anti-fibrotic effects of gum resin in CCl-induced hepatotoxicity.
Eltahir HM, Fawzy MA, Mohamed EM, Alrehany MA, Shehata AM, Abouzied MM

Exp Ther Med. 2020 Feb;19(2):1313-1321.
PMID: 32010304 [PubMed - as supplied by publisher]


Comparative Investigation of Frankincense Nutraceuticals: Correlation of Boswellic and Lupeolic Acid Contents with Cytokine Release Inhibition and Toxicity against Triple-Negative Breast Cancer Cells.
Schmiech M, Lang SJ, Ulrich J, Werner K, Rashan LJ, Syrovets T, Simmet T

Nutrients. 2019 Oct;11(10):.
PMID: 31581678 [PubMed - indexed for MEDLINE]


Pumpkin seeds, Centella asiatica, Boswellia, Helichrysum, acetate vitamin E, Melaleuca alternifolia and hyaluronic acid phytocomplex monotherapy effects in patients with chronic pelvic pain syndrome.
Di Vico T, Durante J, Polito C, Tognarelli A, Canale D, Caglieresi C, Morelli G, Bartoletti R

Minerva Urol Nefrol. 2020 Apr;72(2):236-242.
PMID: 31558010 [PubMed - indexed for MEDLINE]


Functional improvement and immune-inflammatory cytokines profile of ischaemic stroke patients after treatment with boswellic acids: a randomized, double-blind, placebo-controlled, pilot trial.
Baram SM, Karima S, Shateri S, Tafakhori A, Fotouhi A, Lima BS, Rajaei S, Mahdavi M, Tehrani HS, Aghamollaii V, Aghamiri SH, Mansouri B, Gharahje S, Kabiri S, Hosseinizadeh M, Shahamati SZ, Alborzi AT

Inflammopharmacology. 2019 Dec;27(6):1101-1112.
PMID: 31407195 [PubMed - indexed for MEDLINE]


Boswellic extracts and 11-keto-ß-boswellic acids prevent type 1 and type 2 diabetes mellitus by suppressing the expression of proinflammatory cytokines.
Ammon HPT

Phytomedicine. 2019 Oct;63():153002.
PMID: 31301539 [PubMed - indexed for MEDLINE]


Effect of Boswellia Serrata Extract on Acute Inflammatory Parameters and Tumor Necrosis Factor-α in Complete Freund's Adjuvant-Induced Animal Model of Rheumatoid Arthritis.
Kumar R, Singh S, Saksena AK, Pal R, Jaiswal R, Kumar R

Int J Appl Basic Med Res. 2019;9(2):100-106.
PMID: 31041173 [PubMed - as supplied by publisher]


Isolation, structure elucidation, and immunostimulatory activity of polysaccharide fractions from Boswellia carterii frankincense resin.
Hosain NA, Ghosh R, Bryant DL, Arivett BA, Farone AL, Kline PC

Int J Biol Macromol. 2019 Jul;133():76-85.
PMID: 30981779 [PubMed - indexed for MEDLINE]


Effects of Roxb. and L. in an In Vitro Intestinal Inflammation Model Using Immune Cells and Caco-2.
Governa P, Marchi M, Cocetta V, De Leo B, Saunders PTK, Catanzaro D, Miraldi E, Montopoli M, Biagi M

Pharmaceuticals (Basel). 2018 Nov;11(4):.
PMID: 30463367 [PubMed - as supplied by publisher]


Acetyl-11-Keto-β-Boswellic Acid Promotes Osteoblast Differentiation by Inhibiting Tumor Necrosis Factor-α and Nuclear Factor-κB Activity.
Bai F, Chen X, Yang H, Xu HG

J Craniofac Surg. 2018 Oct;29(7):1996-2002.
PMID: 29927820 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid inhibits the secretion of cytokines by dendritic cells via the TLR7/8 pathway in an imiquimod-induced psoriasis mouse model and in vitro.
Wang MX, Zhao JX, Meng YJ, Di TT, Xu XL, Xie XJ, Lin Y, Zhang L, Wang N, Li P, Wang Y

Life Sci. 2018 Aug;207():90-104.
PMID: 29859222 [PubMed - indexed for MEDLINE]


Herbal Products for Common Auto-Inflammatory Disorders - Novel Approaches.
Suroowan S, Mahomoodally F

Comb Chem High Throughput Screen. 2018;21(3):161-174.
PMID: 29436996 [PubMed - indexed for MEDLINE]


The major Boswellia serrata active 3-acetyl-11-keto-β-boswellic acid strengthens interleukin-1α upregulation of matrix metalloproteinase-9 via JNK MAP kinase activation.
Ranzato E, Martinotti S, Volante A, Tava A, Masini MA, Burlando B

Phytomedicine. 2017 Dec;36():176-182.
PMID: 29157812 [PubMed - indexed for MEDLINE]


Antioxidant and Immune System Regulatory Properties of Extracts.
Beghelli D, Isani G, Roncada P, Andreani G, Bistoni O, Bertocchi M, Lupidi G, Alunno A

Oxid Med Cell Longev. 2017;2017():7468064.
PMID: 28386311 [PubMed - indexed for MEDLINE]


Analogues of boswellic acids as inhibitors of pro-inflammatory cytokines TNF-α and IL-6.
Sharma S, Gupta S, Khajuria V, Bhagat A, Ahmed Z, Shah BA

Bioorg Med Chem Lett. 2016 Jan;26(2):695-698.
PMID: 26711891 [PubMed - indexed for MEDLINE]


Boswellic acids target the human immune system-modulating antimicrobial peptide LL-37.
Henkel A, Tausch L, Pillong M, Jauch J, Karas M, Schneider G, Werz O

Pharmacol Res. 2015 Dec;102():53-60.
PMID: 26361729 [PubMed - indexed for MEDLINE]


Comparative anti-inflammatory effects of anti-arthritic herbal medicines and ibuprofen.
Kang JJ, Samad MA, Kim KS, Bae S

Nat Prod Commun. 2014 Sep;9(9):1351-6.
PMID: 25918809 [PubMed - indexed for MEDLINE]


Inhibition of LPS-induced TNF-α and NO production in mouse macrophage and inflammatory response in rat animal models by a novel Ayurvedic formulation, BV-9238.
Dey D, Chaskar S, Athavale N, Chitre D

Phytother Res. 2014 Oct;28(10):1479-85.
PMID: 24706581 [PubMed - indexed for MEDLINE]


Extract from gum resin of Boswellia serrata decreases IA(2)-antibody in a patient with "Late onset Autoimmune Diabetes of the Adult" (LADA).
Schrott E, Laufer S, Lämmerhofer M, Ammon HP

Phytomedicine. 2014 May;21(6):786.
PMID: 24698440 [PubMed - indexed for MEDLINE]


Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis.
Umar S, Umar K, Sarwar AH, Khan A, Ahmad N, Ahmad S, Katiyar CK, Husain SA, Khan HA

Phytomedicine. 2014 May;21(6):847-56.
PMID: 24667331 [PubMed - indexed for MEDLINE]


Boswellic acids reduce Th17 differentiation via blockade of IL-1β-mediated IRAK1 signaling.
Stürner KH, Verse N, Yousef S, Martin R, Sospedra M

Eur J Immunol. 2014 Apr;44(4):1200-12.
PMID: 24469975 [PubMed - indexed for MEDLINE]


[Change in dissolution of chemical components of frankincense-myrrh before and after their compatibility and effect on no release of LPS-induced macrophage cells].
Chen T, Su SL, Duan JA, Shang EX, Qian DW, Tang YP

Zhongguo Zhong Yao Za Zhi. 2013 Jan;38(2):179-85.
PMID: 23672038 [PubMed - indexed for MEDLINE]


Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105.
Khan MK, Ansari IA, Khan MS

Pharmacogn Mag. 2013 Jan;9(33):51-7.
PMID: 23661994 [PubMed - as supplied by publisher]


NF-κB down-regulation and PARP cleavage by novel 3-α-butyryloxy-β-boswellic acid results in cancer cell specific apoptosis and in vivo tumor regression.
Qurishi Y, Hamid A, Sharma PR, Wani ZA, Mondhe DM, Singh SK, Zargar MA, Andotra SS, Shah BA, Taneja SC, Saxena AK

Anticancer Agents Med Chem. 2013 Jun;13(5):777-90.
PMID: 23157593 [PubMed - indexed for MEDLINE]


Efficacy of boswellic acid on lysosomal acid hydrolases, lipid peroxidation and anti-oxidant status in gouty arthritic mice.
Sabina EP, Indu H, Rasool M

Asian Pac J Trop Biomed. 2012 Feb;2(2):128-33.
PMID: 23569882 [PubMed - indexed for MEDLINE]


Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs.
Kumar A, Shah BA, Singh S, Hamid A, Singh SK, Sethi VK, Saxena AK, Singh J, Taneja SC

Bioorg Med Chem Lett. 2012 Jan;22(1):431-5.
PMID: 22123322 [PubMed - indexed for MEDLINE]


Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes.
Akhtar N, Miller MJ, Haqqi TM

BMC Complement Altern Med. 2011 Aug;11():66.
PMID: 21854562 [PubMed - indexed for MEDLINE]


Gum resin of Boswellia serrata inhibited human monocytic (THP-1) cell activation and platelet aggregation.
Kokkiripati PK, Bhakshu LM, Marri S, Padmasree K, Row AT, Raghavendra AS, Tetali SD

J Ethnopharmacol. 2011 Sep;137(1):893-901.
PMID: 21771654 [PubMed - indexed for MEDLINE]


Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract.
Sengupta K, Kolla JN, Krishnaraju AV, Yalamanchili N, Rao CV, Golakoti T, Raychaudhuri S, Raychaudhuri SP

Mol Cell Biochem. 2011 Aug;354(1-2):189-97.
PMID: 21479939 [PubMed - indexed for MEDLINE]


Immunological adjuvant effect of Boswellia serrata (BOS 2000) on specific antibody and cellular response to ovalbumin in mice.
Gupta A, Khajuria A, Singh J, Singh S, Suri KA, Qazi GN

Int Immunopharmacol. 2011 Aug;11(8):968-75.
PMID: 21371582 [PubMed - indexed for MEDLINE]


Traditional herbal remedies that influence cell adhesion molecule activity.
Spelman K, Aldag R, Hamman A, Kwasnik EM, Mahendra MA, Obasi TM, Morse J, Williams EJ

Phytother Res. 2011 Apr;25(4):473-83.
PMID: 21105177 [PubMed - indexed for MEDLINE]


Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage.
Blain EJ, Ali AY, Duance VC

Phytother Res. 2010 Jun;24(6):905-12.
PMID: 19943332 [PubMed - indexed for MEDLINE]


Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis.
Wang H, Syrovets T, Kess D, Büchele B, Hainzl H, Lunov O, Weiss JM, Scharffetter-Kochanek K, Simmet T

J Immunol. 2009 Oct;183(7):4755-63.
PMID: 19752240 [PubMed - indexed for MEDLINE]


Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity.
Subba Rao GS, Kondaiah P, Singh SK, Ravanan P, Sporn MB

Tetrahedron. 2008 Dec;64(51):11541-11548.
PMID: 20622928 [PubMed - as supplied by publisher]


Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration.
Popovic M, Laumonnier Y, Burysek L, Syrovets T, Simmet T

J Leukoc Biol. 2008 Jul;84(1):215-23.
PMID: 18436581 [PubMed - indexed for MEDLINE]


Immunomodulatory activity of biopolymeric fraction BOS 2000 from Boswellia serrata.
Khajuria A, Gupta A, Suden P, Singh S, Malik F, Singh J, Gupta BD, Suri KA, Srinivas VK, Ella K, Qazi GN

Phytother Res. 2008 Mar;22(3):340-8.
PMID: 18167047 [PubMed - indexed for MEDLINE]


Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice.
Cuaz-Pérolin C, Billiet L, Baugé E, Copin C, Scott-Algara D, Genze F, Büchele B, Syrovets T, Simmet T, Rouis M

Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):272-7.
PMID: 18032778 [PubMed - indexed for MEDLINE]


Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation.
Moussaieff A, Shohami E, Kashman Y, Fride E, Schmitz ML, Renner F, Fiebich BL, Munoz E, Ben-Neriah Y, Mechoulam R

Mol Pharmacol. 2007 Dec;72(6):1657-64.
PMID: 17895408 [PubMed - indexed for MEDLINE]


A new vaccine adjuvant (BOS 2000) a potent enhancer mixed Th1/Th2 immune responses in mice immunized with HBsAg.
Khajuria A, Gupta A, Malik F, Singh S, Singh J, Gupta BD, Suri KA, Suden P, Srinivas VK, Ella K, Qazi GN

Vaccine. 2007 Jun;25(23):4586-94.
PMID: 17498851 [PubMed - indexed for MEDLINE]


Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFalpha, IL-1beta, NO and MAP kinases.
Gayathri B, Manjula N, Vinaykumar KS, Lakshmi BS, Balakrishnan A

Int Immunopharmacol. 2007 Apr;7(4):473-82.
PMID: 17321470 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.
Takada Y, Ichikawa H, Badmaev V, Aggarwal BB

J Immunol. 2006 Mar;176(5):3127-40.
PMID: 16493072 [PubMed - indexed for MEDLINE]


Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property.
Pandey RS, Singh BK, Tripathi YB

Indian J Exp Biol. 2005 Jun;43(6):509-16.
PMID: 15991575 [PubMed - indexed for MEDLINE]


Boswellia carterii extract inhibits TH1 cytokines and promotes TH2 cytokines in vitro.
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