8.1.2 Immunsystem

Es ist offenbar, dass wohl im Wesentlichen Teile des Immunsystems, die an Autoimmunerkrankungen beteiligt sind, als Ziel der Wirkung von Boswelliasäuren infrage kommen.

Publikationen

1.

Functional improvement and immune-inflammatory cytokines profile of ischaemic stroke patients after treatment with boswellic acids: a randomized, double-blind, placebo-controlled, pilot trial.
Baram SM, Karima S, Shateri S, Tafakhori A, Fotouhi A, Lima BS, Rajaei S, Mahdavi M, Tehrani HS, Aghamollaii V, Aghamiri SH, Mansouri B, Gharahje S, Kabiri S, Hosseinizadeh M, Shahamati SZ, Alborzi AT

Inflammopharmacology. 2019 Dec;27(6):1101-1112.
PMID: 31407195 [PubMed - as supplied by publisher]

2.

Boswellic extracts and 11-keto-ß-boswellic acids prevent type 1 and type 2 diabetes mellitus by suppressing the expression of proinflammatory cytokines.
Ammon HPT

Phytomedicine. 2019 Oct;63():153002.
PMID: 31301539 [PubMed - as supplied by publisher]

3.

Effect of Boswellia Serrata Extract on Acute Inflammatory Parameters and Tumor Necrosis Factor-α in Complete Freund's Adjuvant-Induced Animal Model of Rheumatoid Arthritis.
Kumar R, Singh S, Saksena AK, Pal R, Jaiswal R, Kumar R

Int J Appl Basic Med Res. 2019 Apr-Jun;9(2):100-106.
PMID: 31041173 [PubMed - as supplied by publisher]

4.

Isolation, structure elucidation, and immunostimulatory activity of polysaccharide fractions from Boswellia carterii frankincense resin.
Hosain NA, Ghosh R, Bryant DL, Arivett BA, Farone AL, Kline PC

Int J Biol Macromol. 2019 Jul;133():76-85.
PMID: 30981779 [PubMed - as supplied by publisher]

5.

Effects of Roxb. and L. in an In Vitro Intestinal Inflammation Model Using Immune Cells and Caco-2.
Governa P, Marchi M, Cocetta V, De Leo B, Saunders PTK, Catanzaro D, Miraldi E, Montopoli M, Biagi M

Pharmaceuticals (Basel). 2018 Nov;11(4):.
PMID: 30463367 [PubMed - as supplied by publisher]

6.

Acetyl-11-Keto-β-Boswellic Acid Promotes Osteoblast Differentiation by Inhibiting Tumor Necrosis Factor-α and Nuclear Factor-κB Activity.
Bai F, Chen X, Yang H, Xu HG

J Craniofac Surg. 2018 Oct;29(7):1996-2002.
PMID: 29927820 [PubMed - indexed for MEDLINE]

7.

Acetyl-11-keto-β-boswellic acid inhibits the secretion of cytokines by dendritic cells via the TLR7/8 pathway in an imiquimod-induced psoriasis mouse model and in vitro.
Wang MX, Zhao JX, Meng YJ, Di TT, Xu XL, Xie XJ, Lin Y, Zhang L, Wang N, Li P, Wang Y

Life Sci. 2018 Aug;207():90-104.
PMID: 29859222 [PubMed - indexed for MEDLINE]

8.

Herbal Products for Common Auto-Inflammatory Disorders - Novel Approaches.
Suroowan S, Mahomoodally F

Comb Chem High Throughput Screen. 2018;21(3):161-174.
PMID: 29436996 [PubMed - indexed for MEDLINE]

9.

The major Boswellia serrata active 3-acetyl-11-keto-β-boswellic acid strengthens interleukin-1α upregulation of matrix metalloproteinase-9 via JNK MAP kinase activation.
Ranzato E, Martinotti S, Volante A, Tava A, Masini MA, Burlando B

Phytomedicine. 2017 Dec;36():176-182.
PMID: 29157812 [PubMed - indexed for MEDLINE]

10.

Antioxidant and Immune System Regulatory Properties of Extracts.
Beghelli D, Isani G, Roncada P, Andreani G, Bistoni O, Bertocchi M, Lupidi G, Alunno A

Oxid Med Cell Longev. 2017;2017():7468064.
PMID: 28386311 [PubMed - indexed for MEDLINE]

11.

Analogues of boswellic acids as inhibitors of pro-inflammatory cytokines TNF-α and IL-6.
Sharma S, Gupta S, Khajuria V, Bhagat A, Ahmed Z, Shah BA

Bioorg Med Chem Lett. 2016 Jan;26(2):695-698.
PMID: 26711891 [PubMed - indexed for MEDLINE]

12.

Boswellic acids target the human immune system-modulating antimicrobial peptide LL-37.
Henkel A, Tausch L, Pillong M, Jauch J, Karas M, Schneider G, Werz O

Pharmacol Res. 2015 Dec;102():53-60.
PMID: 26361729 [PubMed - indexed for MEDLINE]

13.

Comparative anti-inflammatory effects of anti-arthritic herbal medicines and ibuprofen.
Kang JJ, Samad MA, Kim KS, Bae S

Nat Prod Commun. 2014 Sep;9(9):1351-6.
PMID: 25918809 [PubMed - indexed for MEDLINE]

14.

Inhibition of LPS-induced TNF-α and NO production in mouse macrophage and inflammatory response in rat animal models by a novel Ayurvedic formulation, BV-9238.
Dey D, Chaskar S, Athavale N, Chitre D

Phytother Res. 2014 Oct;28(10):1479-85.
PMID: 24706581 [PubMed - indexed for MEDLINE]

15.

Extract from gum resin of Boswellia serrata decreases IA(2)-antibody in a patient with "Late onset Autoimmune Diabetes of the Adult" (LADA).
Schrott E, Laufer S, Lämmerhofer M, Ammon HP

Phytomedicine. 2014 May;21(6):786.
PMID: 24698440 [PubMed - indexed for MEDLINE]

16.

Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis.
Umar S, Umar K, Sarwar AH, Khan A, Ahmad N, Ahmad S, Katiyar CK, Husain SA, Khan HA

Phytomedicine. 2014 May;21(6):847-56.
PMID: 24667331 [PubMed - indexed for MEDLINE]

17.

Boswellic acids reduce Th17 differentiation via blockade of IL-1β-mediated IRAK1 signaling.
Stürner KH, Verse N, Yousef S, Martin R, Sospedra M

Eur J Immunol. 2014 Apr;44(4):1200-12.
PMID: 24469975 [PubMed - indexed for MEDLINE]

18.

[Change in dissolution of chemical components of frankincense-myrrh before and after their compatibility and effect on no release of LPS-induced macrophage cells].
Chen T, Su SL, Duan JA, Shang EX, Qian DW, Tang YP

Zhongguo Zhong Yao Za Zhi. 2013 Jan;38(2):179-85.
PMID: 23672038 [PubMed - indexed for MEDLINE]

19.

Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105.
Khan MK, Ansari IA, Khan MS, Arif JM

Pharmacogn Mag. 2013 Jan;9(33):51-7.
PMID: 23661994 [PubMed - as supplied by publisher]

20.

NF-κB down-regulation and PARP cleavage by novel 3-α-butyryloxy-β-boswellic acid results in cancer cell specific apoptosis and in vivo tumor regression.
Qurishi Y, Hamid A, Sharma PR, Wani ZA, Mondhe DM, Singh SK, Zargar MA, Andotra SS, Shah BA, Taneja SC, Saxena AK

Anticancer Agents Med Chem. 2013 Jun;13(5):777-90.
PMID: 23157593 [PubMed - indexed for MEDLINE]

21.

Efficacy of boswellic acid on lysosomal acid hydrolases, lipid peroxidation and anti-oxidant status in gouty arthritic mice.
Sabina EP, Indu H, Rasool M

Asian Pac J Trop Biomed. 2012 Feb;2(2):128-33.
PMID: 23569882 [PubMed - indexed for MEDLINE]

22.

Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs.
Kumar A, Shah BA, Singh S, Hamid A, Singh SK, Sethi VK, Saxena AK, Singh J, Taneja SC

Bioorg Med Chem Lett. 2012 Jan;22(1):431-5.
PMID: 22123322 [PubMed - indexed for MEDLINE]

23.

Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes.
Akhtar N, Miller MJ, Haqqi TM

BMC Complement Altern Med. 2011 Aug;11():66.
PMID: 21854562 [PubMed - indexed for MEDLINE]

24.

Gum resin of Boswellia serrata inhibited human monocytic (THP-1) cell activation and platelet aggregation.
Kokkiripati PK, Bhakshu LM, Marri S, Padmasree K, Row AT, Raghavendra AS, Tetali SD

J Ethnopharmacol. 2011 Sep;137(1):893-901.
PMID: 21771654 [PubMed - indexed for MEDLINE]

25.

Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract.
Sengupta K, Kolla JN, Krishnaraju AV, Yalamanchili N, Rao CV, Golakoti T, Raychaudhuri S, Raychaudhuri SP

Mol Cell Biochem. 2011 Aug;354(1-2):189-97.
PMID: 21479939 [PubMed - indexed for MEDLINE]

26.

Immunological adjuvant effect of Boswellia serrata (BOS 2000) on specific antibody and cellular response to ovalbumin in mice.
Gupta A, Khajuria A, Singh J, Singh S, Suri KA, Qazi GN

Int Immunopharmacol. 2011 Aug;11(8):968-75.
PMID: 21371582 [PubMed - indexed for MEDLINE]

27.

Traditional herbal remedies that influence cell adhesion molecule activity.
Spelman K, Aldag R, Hamman A, Kwasnik EM, Mahendra MA, Obasi TM, Morse J, Williams EJ

Phytother Res. 2011 Apr;25(4):473-83.
PMID: 21105177 [PubMed - indexed for MEDLINE]

28.

Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage.
Blain EJ, Ali AY, Duance VC

Phytother Res. 2010 Jun;24(6):905-12.
PMID: 19943332 [PubMed - indexed for MEDLINE]

29.

Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis.
Wang H, Syrovets T, Kess D, Büchele B, Hainzl H, Lunov O, Weiss JM, Scharffetter-Kochanek K, Simmet T

J Immunol. 2009 Oct;183(7):4755-63.
PMID: 19752240 [PubMed - indexed for MEDLINE]

30.

Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity.
Subba Rao GS, Kondaiah P, Singh SK, Ravanan P, Sporn MB

Tetrahedron. 2008 Dec;64(51):11541-11548.
PMID: 20622928 [PubMed - as supplied by publisher]

31.

Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration.
Popovic M, Laumonnier Y, Burysek L, Syrovets T, Simmet T

J Leukoc Biol. 2008 Jul;84(1):215-23.
PMID: 18436581 [PubMed - indexed for MEDLINE]

32.

Immunomodulatory activity of biopolymeric fraction BOS 2000 from Boswellia serrata.
Khajuria A, Gupta A, Suden P, Singh S, Malik F, Singh J, Gupta BD, Suri KA, Srinivas VK, Ella K, Qazi GN

Phytother Res. 2008 Mar;22(3):340-8.
PMID: 18167047 [PubMed - indexed for MEDLINE]

33.

Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice.
Cuaz-Pérolin C, Billiet L, Baugé E, Copin C, Scott-Algara D, Genze F, Büchele B, Syrovets T, Simmet T, Rouis M

Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):272-7.
PMID: 18032778 [PubMed - indexed for MEDLINE]

34.

Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation.
Moussaieff A, Shohami E, Kashman Y, Fride E, Schmitz ML, Renner F, Fiebich BL, Munoz E, Ben-Neriah Y, Mechoulam R

Mol Pharmacol. 2007 Dec;72(6):1657-64.
PMID: 17895408 [PubMed - indexed for MEDLINE]

35.

A new vaccine adjuvant (BOS 2000) a potent enhancer mixed Th1/Th2 immune responses in mice immunized with HBsAg.
Khajuria A, Gupta A, Malik F, Singh S, Singh J, Gupta BD, Suri KA, Suden P, Srinivas VK, Ella K, Qazi GN

Vaccine. 2007 Jun;25(23):4586-94.
PMID: 17498851 [PubMed - indexed for MEDLINE]

36.

Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFalpha, IL-1beta, NO and MAP kinases.
Gayathri B, Manjula N, Vinaykumar KS, Lakshmi BS, Balakrishnan A

Int Immunopharmacol. 2007 Apr;7(4):473-82.
PMID: 17321470 [PubMed - indexed for MEDLINE]

37.

Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.
Takada Y, Ichikawa H, Badmaev V, Aggarwal BB

J Immunol. 2006 Mar;176(5):3127-40.
PMID: 16493072 [PubMed - indexed for MEDLINE]

38.

Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property.
Pandey RS, Singh BK, Tripathi YB

Indian J Exp Biol. 2005 Jun;43(6):509-16.
PMID: 15991575 [PubMed - indexed for MEDLINE]

39.

Boswellia carterii extract inhibits TH1 cytokines and promotes TH2 cytokines in vitro.
Chevrier MR, Ryan AE, Lee DY, Zhongze M, Wu-Yan Z, Via CS

Clin Diagn Lab Immunol. 2005 May;12(5):575-80.
PMID: 15879017 [PubMed - indexed for MEDLINE]

40.

Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells.
Roy S, Khanna S, Shah H, Rink C, Phillips C, Preuss H, Subbaraju GV, Trimurtulu G, Krishnaraju AV, Bagchi M, Bagchi D, Sen CK

DNA Cell Biol. 2005 Apr;24(4):244-55.
PMID: 15812241 [PubMed - indexed for MEDLINE]

41.

Acetyl-boswellic acids inhibit lipopolysaccharide-mediated TNF-alpha induction in monocytes by direct interaction with IkappaB kinases.
Syrovets T, Büchele B, Krauss C, Laumonnier Y, Simmet T

J Immunol. 2005 Jan;174(1):498-506.
PMID: 15611276 [PubMed - indexed for MEDLINE]

42.

Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb.
Pungle P, Banavalikar M, Suthar A, Biyani M, Mengi S

Indian J Exp Biol. 2003 Dec;41(12):1460-2.
PMID: 15320503 [PubMed - indexed for MEDLINE]

43.

Immunomodulatory triterpenoids from the oleogum resin of Boswellia carterii Birdwood.
Badria FA, Mikhaeil BR, Maatooq GT, Amer MM

Z Naturforsch C J Biosci. 2003 Jul-Aug;58(7-8):505-16.
PMID: 12939036 [PubMed - indexed for MEDLINE]

44.

Chemistry and immunomodulatory activity of frankincense oil.
Mikhaeil BR, Maatooq GT, Badria FA, Amer MM

Z Naturforsch C J Biosci. 2003 Mar-Apr;58(3-4):230-8.
PMID: 12710734 [PubMed - indexed for MEDLINE]

45.

Boswellic acid, a potent antiinflammatory drug, inhibits rejection to the same extent as high dose steroids.
Dahmen U, Gu YL, Dirsch O, Fan LM, Li J, Shen K, Broelsch CE

Transplant Proc. 2001 Feb-Mar;33(1-2):539-41.
PMID: 11266947 [PubMed - indexed for MEDLINE]

46.

Effects of boswellic acid of Boswellia serrata and other triterpenic acids on the complement system.
Knaus U, Wagner H

Phytomedicine. 1996 May;3(1):77-80.
PMID: 23194867 [PubMed - as supplied by publisher]

47.

Anticomplementary activity of boswellic acids--an inhibitor of C3-convertase of the classical complement pathway.
Kapil A, Moza N

Int J Immunopharmacol. 1992 Oct;14(7):1139-43.
PMID: 1452399 [PubMed - indexed for MEDLINE]

48.

Effect of salai guggal ex-Boswellia serrata on cellular and humoral immune responses and leucocyte migration.
Sharma ML, Khajuria A, Kaul A, Singh S, Singh GB, Atal CK

Agents Actions. 1988 Jun;24(1-2):161-4.
PMID: 3407547 [PubMed - indexed for MEDLINE]