11.2 Rheumatoide Erkrankungen

Anfang der 90er Jahre wurden eine Reihe nichtpublizierter Studien vorgestellt, die meist eine Wirksamkeit von Boswelliaextrakten (u.a. H 15 Ayurmedica) bei rheumatoider Arthritis nahe legen:



Eine weitere Studie zur Osteoarthritis erschien 2003 von Kimmatkar et al.:





A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee.
Majeed M, Majeed S, Narayanan NK, Nagabhushanam K

Phytother Res. 2019 May;33(5):1457-1468.
PMID: 30838706 [PubMed - indexed for MEDLINE]


An Anecdote About Arthritis and Boswellia serrata.
Shader RI

Clin Ther. 2018 05;40(5):669-671.
PMID: 29735296 [PubMed - as supplied by publisher]


A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving Joint Discomfort in Human Subjects with Osteoarthritis of Knee.
Karlapudi V, Prasad Mungara AVV, Sengupta K, Davis BA, Raychaudhuri SP

J Med Food. 2018 May;21(5):511-520.
PMID: 29708818 [PubMed - indexed for MEDLINE]


Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis.
Bannuru RR, Osani MC, Al-Eid F, Wang C

Semin Arthritis Rheum. 2018 12;48(3):416-429.
PMID: 29622343 [PubMed - indexed for MEDLINE]


Phytoproflex®: supplementary management of osteoarthrosis: a supplement registry.
Belcaro G, Dugall M, Luzzi R, Hosoi M, Ledda A, Feragalli B, Hu S, Ganguly A, Eggenhoffner R, Corti A, Giacomelli L

Minerva Med. 2018 Apr;109(2):88-94.
PMID: 29534559 [PubMed - indexed for MEDLINE]


Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study.
Haroyan A, Mukuchyan V, Mkrtchyan N, Minasyan N, Gasparyan S, Sargsyan A, Narimanyan M, Hovhannisyan A

BMC Complement Altern Med. 2018 Jan;18(1):7.
PMID: 29316908 [PubMed - indexed for MEDLINE]


Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.
Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ

Br J Sports Med. 2018 Feb;52(3):167-175.
PMID: 29018060 [PubMed - indexed for MEDLINE]


Oral herbal medicines marketed in Brazil for the treatment of osteoarthritis: A systematic review and meta-analysis.
Del Grossi Moura M, Lopes LC, Biavatti MW, Kennedy SA, de Oliveira E Silva MC, Silva MT, de Cássia Bergamaschi C

Phytother Res. 2017 Nov;31(11):1676-1685.
PMID: 28872719 [PubMed - indexed for MEDLINE]


Evaluation of the effect of Elaeagnus angustifolia alone and combined with Boswellia thurifera compared with ibuprofen in patients with knee osteoarthritis: a randomized double-blind controlled clinical trial.
Karimifar M, Soltani R, Hajhashemi V, Sarrafchi S

Clin Rheumatol. 2017 Aug;36(8):1849-1853.
PMID: 28349271 [PubMed - indexed for MEDLINE]


Phytomedicine in Joint Disorders.
Dragos D, Gilca M, Gaman L, Vlad A, Iosif L, Stoian I, Lupescu O

Nutrients. 2017 Jan;9(1):.
PMID: 28275210 [PubMed - indexed for MEDLINE]


Five Herbs Plus Thiamine Reduce Pain and Improve Functional Mobility in Patients With Pain: A Pilot Study.
Hedaya R

Altern Ther Health Med. 2017 Jan;23(1):14-19.
PMID: 28160759 [PubMed - indexed for MEDLINE]


Movardol® (N-acetylglucosamine, Boswellia serrata, ginger) supplementation in the management of knee osteoarthritis: preliminary results from a 6-month registry study.
Bolognesi G, Belcaro G, Feragalli B, Cornelli U, Cotellese R, Hu S, Dugall M

Eur Rev Med Pharmacol Sci. 2016 12;20(24):5198-5204.
PMID: 28051248 [PubMed - indexed for MEDLINE]


Management strategies for knee osteoarthritis: Aflapin ().
Suva MA, Kheni DB, Sureja VP

Ayu. 2017 Jan-Jun;38(1-2):94.
PMID: 29861602 [PubMed - as supplied by publisher]


In Vivo Osteoinduction: Evaluating 2-Beta Coxatene as an Immunoinductive Compound and Novel Ingredient for Joint Support.
Spinks K, Scaffidi JJ

Integr Med (Encinitas). 2016 Oct;15(5):34-44.
PMID: 27980494 [PubMed - as supplied by publisher]


A novel lecithin based delivery form of Boswellic acids (Casperome®) for the management of osteo-muscular pain: a registry study in young rugby players.
Franceschi F, Togni S, Belcaro G, Dugall M, Luzzi R, Ledda A, Pellegrini L, Eggenhoffner R, Giacomelli L

Eur Rev Med Pharmacol Sci. 2016 10;20(19):4156-4161.
PMID: 27775780 [PubMed - indexed for MEDLINE]


Clinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritis.
Ricci M, Micheloni GM, Berti M, Perusi F, Sambugaro E, Vecchini E, Magnan B

Musculoskelet Surg. 2017 Apr;101(1):45-49.
PMID: 27681813 [PubMed - indexed for MEDLINE]


Nutraceutical supplement in the management of tendinopathies: a systematic review.
Fusini F, Bisicchia S, Bottegoni C, Gigante A, Zanchini F, Busilacchi A

Muscles Ligaments Tendons J. 2016 Jan-Mar;6(1):48-57.
PMID: 27331031 [PubMed - as supplied by publisher]


Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality.
Grover AK, Samson SE

Nutr J. 2016 Jan;15():1.
PMID: 26728196 [PubMed - indexed for MEDLINE]


Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial.
Notarnicola A, Maccagnano G, Moretti L, Pesce V, Tafuri S, Fiore A, Moretti B

Int J Immunopathol Pharmacol. 2016 Mar;29(1):140-6.
PMID: 26684635 [PubMed - indexed for MEDLINE]


Hand 'stress' arthritis in young subjects: effects of Flexiqule (pharma-standard Boswellia extract). A preliminary case report.
Belcaro G, Feragalli B, Cornelli U, Dugall M

Minerva Gastroenterol Dietol. 2015 Oct;():.
PMID: 26492590 [PubMed - as supplied by publisher]


Management of osteoarthritis (OA) with the pharma-standard supplement FlexiQule (Boswellia): a 12-week registry.
Belcaro G, Dugall M, Luzzi R, Ledda A, Pellegrini L, Hu S, Ippolito E

Minerva Gastroenterol Dietol. 2015 Oct;():.
PMID: 26492586 [PubMed - as supplied by publisher]


Effect of Sri Lankan traditional medicine and Ayurveda on Sandhigata Vata (osteoarthritis of knee joint).
Perera PK, Perera M, Kumarasinghe N

Ayu. 2014 Oct-Dec;35(4):411-5.
PMID: 26195904 [PubMed - as supplied by publisher]


FlexiQule (Boswellia extract) in the supplementary management of osteoarthritis: a supplement registry.
Belcaro G, Dugall M, Luzzi R, Ledda A, Pellegrini L, Cesarone MR, Hosoi M, Errichi M, Francis S, Cornelli U

Minerva Med. 2014 Dec;105(6 Suppl 2):9-16.
PMID: 26076376 [PubMed - indexed for MEDLINE]


Co-analgesic therapy for arthroscopic supraspinatus tendon repair pain using a dietary supplement containing Boswellia serrata and Curcuma longa: a prospective randomized placebo-controlled study.
Merolla G, Dellabiancia F, Ingardia A, Paladini P, Porcellini G

Musculoskelet Surg. 2015 Sep;99 Suppl 1():S43-52.
PMID: 25957549 [PubMed - indexed for MEDLINE]


A medicinal herb-based natural health product improves the condition of a canine natural osteoarthritis model: a randomized placebo-controlled trial.
Moreau M, Lussier B, Pelletier JP, Martel-Pelletier J, Bédard C, Gauvin D, Troncy E

Res Vet Sci. 2014 Dec;97(3):574-81.
PMID: 25311158 [PubMed - indexed for MEDLINE]


Oral herbal therapies for treating osteoarthritis.
Cameron M, Chrubasik S

Cochrane Database Syst Rev. 2014 May;(5):CD002947.
PMID: 24848732 [PubMed - indexed for MEDLINE]


A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial.
Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, Sha W

Nutr J. 2013 Nov;12(1):154.
PMID: 24274358 [PubMed - indexed for MEDLINE]


Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis.
Kizhakkedath R

Mol Med Rep. 2013 Nov;8(5):1542-8.
PMID: 24002213 [PubMed - indexed for MEDLINE]


Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial.
Chopra A, Saluja M, Tillu G, Sarmukkaddam S, Venugopalan A, Narsimulu G, Handa R, Sumantran V, Raut A, Bichile L, Joshi K, Patwardhan B

Rheumatology (Oxford). 2013 Aug;52(8):1408-17.
PMID: 23365148 [PubMed - indexed for MEDLINE]


Clinical evaluation of Boswellia serrata (Shallaki) resin in the management of Sandhivata (osteoarthritis).
Gupta PK, Samarakoon SM, Chandola HM, Ravishankar B

Ayu. 2011 Oct;32(4):478-82.
PMID: 22661840 [PubMed - as supplied by publisher]


A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee.
Vishal AA, Mishra A, Raychaudhuri SP

Int J Med Sci. 2011;8(7):615-22.
PMID: 22022214 [PubMed - indexed for MEDLINE]


The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis.
Notarnicola A, Tafuri S, Fusaro L, Moretti L, Pesce V, Moretti B

Adv Ther. 2011 Oct;28(10):894-906.
PMID: 21986780 [PubMed - indexed for MEDLINE]


Antiarthritic activity of a standardized, multiherbal, Ayurvedic formulation containing Boswellia serrata: in vitro studies on knee cartilage from osteoarthritis patients.
Sumantran VN, Joshi AK, Boddul S, Koppikar SJ, Warude D, Patwardhan B, Chopra A, Chandwaskar R, Wagh UV

Phytother Res. 2011 Sep;25(9):1375-80.
PMID: 25363757 [PubMed - indexed for MEDLINE]


Comparative efficacy and tolerability of 5-Loxin and AflapinAgainst osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study.
Sengupta K, Krishnaraju AV, Vishal AA, Mishra A, Trimurtulu G, Sarma KV, Raychaudhuri SK, Raychaudhuri SP

Int J Med Sci. 2010 Nov;7(6):366-77.
PMID: 21060724 [PubMed - indexed for MEDLINE]


A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee.
Sengupta K, Alluri KV, Satish AR, Mishra S, Golakoti T, Sarma KV, Dey D, Raychaudhuri SP

Arthritis Res Ther. 2008;10(4):R85.
PMID: 18667054 [PubMed - indexed for MEDLINE]


Nutraceuticals in the management of osteoarthritis.
Clayton JJ

Orthopedics. 2007 08;30(8):624-9; quiz 630-1.
PMID: 17727018 [PubMed - indexed for MEDLINE]


Natural products as a gold mine for arthritis treatment.
Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB

Curr Opin Pharmacol. 2007 Jun;7(3):344-51.
PMID: 17475558 [PubMed - indexed for MEDLINE]


Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain.
Chrubasik JE, Roufogalis BD, Chrubasik S

Phytother Res. 2007 Jul;21(7):675-83.
PMID: 17444576 [PubMed - indexed for MEDLINE]


A 32-week randomized, placebo-controlled clinical evaluation of RA-11, an Ayurvedic drug, on osteoarthritis of the knees.
Chopra A, Lavin P, Patwardhan B, Chitre D

J Clin Rheumatol. 2004 Oct;10(5):236-45.
PMID: 17043520 [PubMed - as supplied by publisher]


Dietary support with Boswellia resin in canine inflammatory joint and spinal disease.
Reichling J, Schmökel H, Fitzi J, Bucher S, Saller R

Schweiz Arch Tierheilkd. 2004 Feb;146(2):71-9.
PMID: 14994484 [PubMed - indexed for MEDLINE]


Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial.
Kimmatkar N, Thawani V, Hingorani L, Khiyani R

Phytomedicine. 2003 Jan;10(1):3-7.
PMID: 12622457 [PubMed - indexed for MEDLINE]


[Is H15 (resin extract of Boswellia serrata, "incense") a useful supplement to established drug therapy of chronic polyarthritis? Results of a double-blind pilot study].
Sander O, Herborn G, Rau R

Z Rheumatol. 1998 Feb;57(1):11-6.
PMID: 9566100 [PubMed - indexed for MEDLINE]


Special extract of BOSWELLIA serrata (H 15) in the treatment of rheumatoid arthritis.
Etzel R

Phytomedicine. 1996 May;3(1):91-4.
PMID: 23194870 [PubMed - as supplied by publisher]


Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study.
Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B

J Ethnopharmacol. 1991 May-Jun;33(1-2):91-5.
PMID: 1943180 [PubMed - indexed for MEDLINE]