8.2.6 Leber



3-Acetyl-11-keto-β-boswellic Acid-Based Hybrids Alleviate Acetaminophen-Induced Hepatotoxicity in HepG2 by the Regulation of Inflammatory and Oxidative Stress Pathways: An Integrated Approach.
Elgazar AA, El-Domany RA, Eldehna WM, Badria FA

ACS Omega. 2023 Oct;8(42):39490-39510.
PMID: 37901542 [PubMed - as supplied by publisher]


Guided discovery of hepatoprotective polyhydroxy cembrane-type diterpenoids from the gum resin of Boswellia carterii by MS/MS molecular networking.
Yu J, Zhao L, Wang Z, Yue T, Wang X

Phytochemistry. 2023 Dec;216():113897.
PMID: 37866446 [PubMed - indexed for MEDLINE]


Pathophysiology of diabetic hepatopathy and molecular mechanisms underlying the hepatoprotective effects of phytochemicals.
Mobasheri L, Ahadi M, Beheshti Namdar A, Alavi MS, Bemidinezhad A, Moshirian Farahi SM, Esmaeilizadeh M, Nikpasand N, Einafshar E, Ghorbani A

Biomed Pharmacother. 2023 Nov;167():115502.
PMID: 37734266 [PubMed - as supplied by publisher]


Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease mouse model: novel mechanistic insight.
Salama RM, Abbas SS, Darwish SF, Sallam AA, Elmongy NF, El Wakeel SA

Arch Pharm Res. 2023 Apr;46(4):323-338.
PMID: 36959348 [PubMed - indexed for MEDLINE]


Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways.
Zheng P, Huang Z, Tong DC, Zhou Q, Tian S, Chen BW, Ning DM, Guo YM, Zhu WH, Long Y, Xiao W, Deng Z, Lei YC, Tian XF

World J Gastrointest Oncol. 2022 Feb;14(2):450-477.
PMID: 35317323 [PubMed - as supplied by publisher]


Anti-inflammatory and hepatoprotective cembranoid alcohols from the Gum Resin of Boswellia carterii.
Yu J, Zhao L, Zhang K, Wang X

Fitoterapia. 2021 Nov;155():105064.
PMID: 34656670 [PubMed - indexed for MEDLINE]


Evaluation of the solubility of 11-keto-β-boswellic acid and its histological effect on the diabetic mice liver using a novel technique.
Amri IA, Mabood F, Kadim IT, Alkindi A, Al-Harrasi A, Al-Hashmi S, Abbas G, Hamaed A, Ahmed B, Al-Shuhaimi J, Khalaf S, Shaikh J

Vet World. 2021 Jul;14(7):1797-1803.
PMID: 34475700 [PubMed - as supplied by publisher]


Boswellia Serrata

. 2012;():.
PMID: 33151656 [PubMed - as supplied by publisher]


Bioactive cembrane diterpenoids from the gum resin of Boswellia carterii.
Yu J, Zhao L, Sun X, Geng Y, Wang X

Fitoterapia. 2020 Oct;146():104699.
PMID: 32763364 [PubMed - indexed for MEDLINE]


Ten undescribed cembrane-type diterpenoids from the gum resin of Boswellia sacra and their biological activities.
Wang JJ, Sun HR, Suo XY, Xue Wang , Sun H, Wang XL, Jiang JD, Ji TF

Phytochemistry. 2020 Sep;177():112425.
PMID: 32535347 [PubMed - indexed for MEDLINE]


Boswellic acid protects against Bisphenol-A and gamma radiation induced hepatic steatosis and cardiac remodelling in rats: role of hepatic PPAR-α/P38 and cardiac Calcineurin-A/NFATc1/P38 pathways.
Thabet NM, Abdel-Rafei MK, Moustafa EM

Arch Physiol Biochem. 2022 Jun;128(3):767-785.
PMID: 32057248 [PubMed - indexed for MEDLINE]


Antioxidant, anti-inflammatory and anti-fibrotic effects of gum resin in CCl-induced hepatotoxicity.
Eltahir HM, Fawzy MA, Mohamed EM, Alrehany MA, Shehata AM, Abouzied MM

Exp Ther Med. 2020 Feb;19(2):1313-1321.
PMID: 32010304 [PubMed - as supplied by publisher]


Cembrane-type diterpenoids from the gum resin of and their biological activities.
Sun X, Geng Y, Wang X, Qin D, Yu J

RSC Adv. 2020 Jan;10(2):746-755.
PMID: 35494443 [PubMed - as supplied by publisher]


Bioactive cembrane-type diterpenoids from the gum-resin of Boswellia carterii.
Wang YG, Ren J, Ma J, Yang JB, Ji T, Wang AG

Fitoterapia. 2019 Sep;137():104263.
PMID: 31295512 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid triggers premature senescence via induction of DNA damage accompanied by impairment of DNA repair genes in hepatocellular carcinoma cells in vitro and in vivo.
Wang S, Wang H, Sun B, Li D, Wu J, Li J, Tian X, Qin C, Chang H, Liu Y

Fundam Clin Pharmacol. 2020 Feb;34(1):65-76.
PMID: 31141202 [PubMed - indexed for MEDLINE]


Boscartins L-O: Cembrane-type diterpenoids from the gum resin of Boswellia sacra Flueck.
Wang J, Zhen B, Hu J, Shi M, Wei C, Wang X, Sun H, Ji T

Phytochemistry. 2019 Jul;163():126-131.
PMID: 31059964 [PubMed - indexed for MEDLINE]


An Approach to Treatment of Liver Cancer by Novel Glycyrrhizin Derivative.
El-Senduny FF, Zidane MM, Youssef MM, Badria FA

Anticancer Agents Med Chem. 2019;19(15):1863-1873.
PMID: 30973113 [PubMed - indexed for MEDLINE]


Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway.
Barakat BM, Ahmed HI, Bahr HI, Elbahaie AM

Oxid Med Cell Longev. 2018;2018():8296451.
PMID: 29541348 [PubMed - indexed for MEDLINE]


Alleviative effects from boswellic acid on acetaminophen-induced hepatic injury - Corrected and republished from: Biomedicine (Taipei). 2016 Jun; 6 (2): 9. doi: 10.7603/s40681-016-0009-1PMCID: PMC4864770.
Chen LC, Hu LH, Yin MC

Biomedicine (Taipei). 2017 Jun;7(2):13.
PMID: 28612711 [PubMed - as supplied by publisher]


Correction notice to: Alleviative effects from boswellic acid on acetaminophen-induced hepatic injury - Biomedicine (Taipei). 2016 Jun; 6 (2): 9. DOI: 10.7603/s40681-016-0009-1.
Chen LC, Hu LH, Yin MC

Biomedicine (Taipei). 2017 Mar;7(1):7.
PMID: 28474583 [PubMed - as supplied by publisher]


Understanding the role of 3-O-Acetyl-11-keto-β-boswellic acid in conditions of oxidative-stress mediated hepatic dysfunction during benzo(a)pyrene induced toxicity.
Kumar M, Singh G, Bhardwaj P, Dhatwalia SK, Dhawan DK

Food Chem Toxicol. 2017 Nov;109(Pt 2):871-878.
PMID: 28363852 [PubMed - indexed for MEDLINE]


Effect of Boswellia serrata Resin Supplementation on Basic Chemical and Mineral Element Composition in the Muscles and Liver of Broiler Chickens.
Al-Yasiry ARM, Kiczorowska B, Samolińska W

Biol Trace Elem Res. 2017 Oct;179(2):294-303.
PMID: 28210929 [PubMed - indexed for MEDLINE]


Alleviative effects from boswellic acid on acetaminophen-induced hepatic injury.
Chen LC, Hu LH, Yin MC

Biomedicine (Taipei). 2016 Jun;6(2):9.
PMID: 27161000 [PubMed - as supplied by publisher]


Hepatoprotective triterpenes from the gum resin of Boswellia carterii.
Wang YG, Ma QG, Tian J, Ren J, Wang AG, Ji TF, Yang JB, Su YL

Fitoterapia. 2016 Mar;109():266-73.
PMID: 26739386 [PubMed - indexed for MEDLINE]


Protective effect of boswellic acids versus pioglitazone in a rat model of diet-induced non-alcoholic fatty liver disease: influence on insulin resistance and energy expenditure.
Zaitone SA, Barakat BM, Bilasy SE, Fawzy MS, Abdelaziz EZ, Farag NE

Naunyn Schmiedebergs Arch Pharmacol. 2015 Jun;388(6):587-600.
PMID: 25708949 [PubMed - indexed for MEDLINE]


Antioxidant and hepatoprotective effects of Boswellia ovalifoliolata bark extracts.
Mahesh BU, Shrivastava S, Pragada RR, Naidu VG, Sistla R

Chin J Nat Med. 2014 Sep;12(9):663-71.
PMID: 25263977 [PubMed - indexed for MEDLINE]


Caspase mediated synergistic effect of Boswellia serrata extract in combination with doxorubicin against human hepatocellular carcinoma.
Khan MA, Singh M, Khan MS, Najmi AK, Ahmad S

Biomed Res Int. 2014;2014():294143.
PMID: 25177685 [PubMed - indexed for MEDLINE]


A boswellic acid-containing extract ameliorates schistosomiasis liver granuloma and fibrosis through regulating NF-κB signaling in mice.
Liu M, Wu Q, Chen P, Büchele B, Bian M, Dong S, Huang D, Ren C, Zhang Y, Hou X, Simmet T, Shen J

PLoS One. 2014;9(6):e100129.
PMID: 24941000 [PubMed - indexed for MEDLINE]


Ultrastructural and hormonal changes in rat cauda epididymal spermatozoa induced by Boswellia papyrifera and Boswellia carterii.
Ahmed M, Ali D, Harrath AH, Hussain T, Al-Daghri N, Alokail MS, Aladakatti RH, Ghodesawar MA

C R Biol. 2014 Apr;337(4):250-7.
PMID: 24702894 [PubMed - indexed for MEDLINE]


Hepatoprotective prenylaromadendrane-type diterpenes from the gum resin of Boswellia carterii.
Wang YG, Ren J, Wang AG, Yang JB, Ji TF, Ma QG, Tian J, Su YL

J Nat Prod. 2013 Nov;76(11):2074-9.
PMID: 24195447 [PubMed - indexed for MEDLINE]


The tyrosine phosphatase SHP-1 inhibits proliferation of activated hepatic stellate cells by impairing PDGF receptor signaling.
Tibaldi E, Zonta F, Bordin L, Magrin E, Gringeri E, Cillo U, Idotta G, Pagano MA, Brunati AM

Biochim Biophys Acta. 2014 Feb;1843(2):288-98.
PMID: 24140598 [PubMed - indexed for MEDLINE]


A boswellic acid-containing extract attenuates hepatic granuloma in C57BL/6 mice infected with Schistosoma japonicum.
Liu M, Chen P, Büchele B, Dong S, Huang D, Ren C, Zhang Y, Hou X, Simmet T, Shen J

Parasitol Res. 2013 Mar;112(3):1105-11.
PMID: 23271565 [PubMed - indexed for MEDLINE]


Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation.
Sferra R, Vetuschi A, Catitti V, Ammanniti S, Pompili S, Melideo D, Frieri G, Gaudio E, Latella G

Eur Rev Med Pharmacol Sci. 2012 Oct;16(11):1484-98.
PMID: 23111960 [PubMed - indexed for MEDLINE]


Effect of hexane extract of Boswellia serrata oleo-gum resin on chemically induced liver damage.
Y J, Kamath JV, Asad M

Pak J Pharm Sci. 2006 Apr;19(2):129-33.
PMID: 16751123 [PubMed - indexed for MEDLINE]