8.3 Tumore

Der erste Bericht über eine Antitumoraktiviträt von Extrakten von Boswellia serrata stammt von Jing und Mitarbeitern (1992) unter Verwendung von menschlichen HL 60 Leukämiezellen.

Untersuchungen, die 1999 in Tübingen durchgeführt wurden, zeigten ebenfalls eine Antitumorwirkung bei HL 60 Leukämiezellen sowie bei Glioblastomzellen. Es stellte sich jedoch bei all diesen Untersuchungen heraus, dass die in vitro verwendeten Konzentrationen von Boswelliaextrakten und Boswelliasäuren, die zur Hemmung des Tumorwachstums notwendig waren, wesentlich höher lagen als diejenigen, die eine Hemmung der Leukotriensynthese in Leukozyten bewirkten, wie dies auch aus der Tabelle hervorgeht. Andererseits ist es jedoch denkbar, dass niedrigere Konzentrationen von Boswelliasäuren bei solchen Tumoren wirksam sein könnten, die eng mit einer erhöhten Bildung von Leukotrien verbunden sind.

Hier einige Daten aus dem Tübinger Institut:




3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.

J Exp Clin Cancer Res. 2018 Jul;37(1):132.
PMID: 29970196 [PubMed - as supplied by publisher]


Combined acetyl-11-keto-β-boswellic acid and radiation treatment inhibited glioblastoma tumor cells.

PLoS One. 2018;13(7):e0198627.
PMID: 29969452 [PubMed - as supplied by publisher]


Homopiperazine-rhodamine B adducts of triterpenoic acids are strong mitocans.

Eur J Med Chem. 2018 Jul;155():869-879.
PMID: 29960206 [PubMed - indexed for MEDLINE]


Inhibitory effect of 11-carbonyl-beta-boswellic acid on non-small cell lung cancer H446 cells.

Biochem Biophys Res Commun. 2018 Sep;503(4):2202-2205.
PMID: 29953860 [PubMed - as supplied by publisher]


Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway.

J BUON. 2018 Mar-Apr;23(2):340-345.
PMID: 29745074 [PubMed - as supplied by publisher]


Utilizing biomarkers in colorectal cancer: an interview with Ajay Goel.

Future Oncol. 2017 Dec;13(28):2511-2514.
PMID: 29168653 [PubMed - indexed for MEDLINE]


Transcriptomic Profiling of MDA-MB-231 Cells Exposed to and 3-O-Acetyl-B-Boswellic Acid; ER/UPR Mediated Programmed Cell Death.

Cancer Genomics Proteomics. 2017 Nov-Dec;14(6):409-425.
PMID: 29109091 [PubMed - indexed for MEDLINE]


Methanolic extract of Boswellia serrata exhibits anti-cancer activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells.

Prostaglandins Other Lipid Mediat. 2017 07;131():1-8.
PMID: 28549801 [PubMed - indexed for MEDLINE]


P-gp modulatory acetyl-11-keto-β-boswellic acid based nanoemulsified carrier system for augmented oral chemotherapy of docetaxel.

Colloids Surf B Biointerfaces. 2017 Jul;155():276-286.
PMID: 28437753 [PubMed - indexed for MEDLINE]


Boswellia serrata resin extract alleviates azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon tumorigenesis.

Mol Nutr Food Res. 2017 09;61(9):.
PMID: 28245338 [PubMed - indexed for MEDLINE]


Design and synthesis of novel 2-substituted 11-keto-boswellic acid heterocyclic derivatives as anti-prostate cancer agents with Pin1 inhibition ability.

Eur J Med Chem. 2017 Jan;126():910-919.
PMID: 27997878 [PubMed - indexed for MEDLINE]


Ring A-modified Derivatives from the Natural Triterpene 3-O-acetyl-11-keto-β-Boswellic Acid and their Cytotoxic Activity.

Anticancer Agents Med Chem. 2017;17(8):1153-1167.
PMID: 27928954 [PubMed - indexed for MEDLINE]


Interplay between cell cycle and autophagy induced by boswellic acid analog.

Sci Rep. 2016 Sep;6():33146.
PMID: 27680387 [PubMed - as supplied by publisher]


Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves.

Pharm Biol. 2017 Dec;55(1):33-42.
PMID: 27650786 [PubMed - indexed for MEDLINE]


Therapeutic potential of boswellic acids: a patent review (1990-2015).

Expert Opin Ther Pat. 2017 Jan;27(1):81-90.
PMID: 27646163 [PubMed - indexed for MEDLINE]


Role of angiogenic factors of herbal origin in regulation of molecular pathways that control tumor angiogenesis.

Tumour Biol. 2016 Nov;37(11):14341-14354.
PMID: 27614685 [PubMed - indexed for MEDLINE]


Chemical composition, antiproliferative, antioxidant and antibacterial activities of essential oils from aromatic plants growing in Sudan.

Asian Pac J Trop Med. 2016 Aug;9(8):763-70.
PMID: 27569885 [PubMed - as supplied by publisher]


Reversal of the multidrug resistance of human ileocecal adenocarcinoma cells by acetyl-11-keto-β-boswellic acid via downregulation of P-glycoprotein signals.

Biosci Trends. 2016 Nov;10(5):392-399.
PMID: 27545217 [PubMed - indexed for MEDLINE]


Improved efficacy of cisplatin in combination with a nano-formulation of pentacyclic triterpenediol.

Mater Sci Eng C Mater Biol Appl. 2016 Nov;68():109-116.
PMID: 27524002 [PubMed - indexed for MEDLINE]


β-Boswellic acid, a bioactive substance used in food supplements, inhibits protein synthesis by targeting the ribosomal machinery.

J Mass Spectrom. 2016 Sep;51(9):821-7.
PMID: 27460774 [PubMed - indexed for MEDLINE]


Boswellic acid disables signal transduction of IL-6-STAT-3 in Ehrlich ascites tumor bearing irradiated mice.

Biochem Cell Biol. 2016 08;94(4):307-13.
PMID: 27458759 [PubMed - indexed for MEDLINE]


Pharmacological evidences for cytotoxic and antitumor properties of Boswellic acids from Boswellia serrata.

J Ethnopharmacol. 2016 Sep;191():315-323.
PMID: 27346540 [PubMed - indexed for MEDLINE]


Boswellic acid activity against glioblastoma stem-like cells.

Oncol Lett. 2016 Jun;11(6):4187-4192.
PMID: 27313764 [PubMed - as supplied by publisher]


Frankincense--therapeutic properties.

Postepy Hig Med Dosw (Online). 2016 Jan;70():380-91.
PMID: 27117114 [PubMed - indexed for MEDLINE]


The potential role of boswellic acids in cancer prevention and treatment.

Cancer Lett. 2016 07;377(1):74-86.
PMID: 27091399 [PubMed - indexed for MEDLINE]


Use of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma.

Dermatol Ther. 2016 11;29(6):393.
PMID: 27003094 [PubMed - indexed for MEDLINE]


Synthesis of β-boswellic acid derivatives as cytotoxic and apoptotic agents.

Bioorg Med Chem Lett. 2016 Jan;26(1):76-81.
PMID: 26608550 [PubMed - indexed for MEDLINE]


Phytochemical Analysis and Anti-cancer Investigation of Boswellia serrata Bioactive Constituents In Vitro.

Asian Pac J Cancer Prev. 2015;16(16):7179-88.
PMID: 26514509 [PubMed - indexed for MEDLINE]


Triggering of Suicidal Erythrocyte Death Following Boswellic Acid Exposure.

Cell Physiol Biochem. 2015;37(1):131-42.
PMID: 26303375 [PubMed - indexed for MEDLINE]


Combination of Anti-Diabetic Drug Metformin and Boswellic Acid Nanoparticles: A Novel Strategy for Pancreatic Cancer Therapy.

J Biomed Nanotechnol. 2015 Jan;11(1):93-104.
PMID: 26301303 [PubMed - indexed for MEDLINE]


Boswellic acids synergize antitumor activity and protect against the cardiotoxicity of doxorubicin in mice bearing Ehrlich's carcinoma.

Can J Physiol Pharmacol. 2015 Aug;93(8):695-708.
PMID: 26230640 [PubMed - indexed for MEDLINE]


11-Keto-boswellic acid derived amides and monodesmosidic saponins induce apoptosis in breast and cervical cancers cells.

Eur J Med Chem. 2015 Jul;100():98-105.
PMID: 26073487 [PubMed - indexed for MEDLINE]


Synthesis and structure-activity relationships of boswellic acid derivatives as potent VEGFR-2 inhibitors.

Bioorg Med Chem. 2015 May;23(9):1982-93.
PMID: 25819335 [PubMed - indexed for MEDLINE]


Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer.

Cancer Prev Res (Phila). 2015 May;8(5):431-43.
PMID: 25712055 [PubMed - indexed for MEDLINE]


Prediction of anticancer property of bowsellic acid derivatives by quantitative structure activity relationship analysis and molecular docking study.

J Pharm Bioallied Sci. 2015 Jan-Mar;7(1):21-5.
PMID: 25709332 [PubMed - as supplied by publisher]


Synthesis and antitumor activity of ring A modified 11-keto-β-boswellic acid derivatives.

Eur J Med Chem. 2015 Mar;92():700-11.
PMID: 25618017 [PubMed - indexed for MEDLINE]


Retraction notice to "Acetyl-11-β-boswellic acid (AKBA)inhibits human gastric carcinoma growth through modulation of the Wnt/β-canetin signalin pathway" Biochimica et Biophysica Acta [1830 (6) 3604-3615].

Biochim Biophys Acta. 2015 Jan;1850(1):254.
PMID: 25610930 [PubMed - indexed for MEDLINE]


Retraction notice to "Acetyl-11-keto-beta-boswellic acid (AKBA) prevents human colonic adenocarcinoma growth through modulation of multiple signaling pathways" Biochimica et Biophysica Acta [1830 (10) 4907-4916].

Biochim Biophys Acta. 2015 Jan;1850(1):253.
PMID: 25610929 [PubMed - indexed for MEDLINE]


The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA145 are potentiated by autophagy inhibitors.

Mol Cancer. 2015 Jan;14():6.
PMID: 25608686 [PubMed - indexed for MEDLINE]


An α-acetoxy-tirucallic acid isomer inhibits Akt/mTOR signaling and induces oxidative stress in prostate cancer cells.

J Pharmacol Exp Ther. 2015 Jan;352(1):33-42.
PMID: 25316122 [PubMed - indexed for MEDLINE]


Effect of boswellia thurifera gum methanol extract on cytotoxicity and p53 gene expression in human breast cancer cell line.

Iran J Pharm Res. 2014;13(2):719-24.
PMID: 25237368 [PubMed - as supplied by publisher]


Caspase mediated synergistic effect of Boswellia serrata extract in combination with doxorubicin against human hepatocellular carcinoma.

Biomed Res Int. 2014;2014():294143.
PMID: 25177685 [PubMed - indexed for MEDLINE]


Design, synthesis and biological evaluation of β-boswellic acid based HDAC inhibitors as inducers of cancer cell death.

Bioorg Med Chem Lett. 2014 Oct;24(19):4729-4734.
PMID: 25176189 [PubMed - indexed for MEDLINE]


Differential effects of selective frankincense (Ru Xiang) essential oil versus non-selective sandalwood (Tan Xiang) essential oil on cultured bladder cancer cells: a microarray and bioinformatics study.

Chin Med. 2014;9():18.
PMID: 25006348 [PubMed - as supplied by publisher]


Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells.

Environ Toxicol Pharmacol. 2014 Jul;38(1):58-70.
PMID: 24908637 [PubMed - indexed for MEDLINE]


Ultrastructural and hormonal changes in rat cauda epididymal spermatozoa induced by Boswellia papyrifera and Boswellia carterii.

C R Biol. 2014 Apr;337(4):250-7.
PMID: 24702894 [PubMed - indexed for MEDLINE]


The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice.

Drug Discov Ther. 2014 Feb;8(1):25-32.
PMID: 24647155 [PubMed - indexed for MEDLINE]


Major constituents of Boswellia carteri resin exhibit cyclooxygenase enzyme inhibition and antiproliferative activity.

Nat Prod Commun. 2013 Oct;8(10):1365-6.
PMID: 24354175 [PubMed - indexed for MEDLINE]


Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059.

Apoptosis. 2013 Dec;18(12):1561-73.
PMID: 23948751 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-beta-boswellic acid (AKBA) prevents human colonic adenocarcinoma growth through modulation of multiple signaling pathways.

Biochim Biophys Acta. 2013 Oct;1830(10):4907-16.
PMID: 23850473 [PubMed - indexed for MEDLINE]


Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105.

Pharmacogn Mag. 2013 Jan;9(33):51-7.
PMID: 23661994 [PubMed - as supplied by publisher]


Boswellic acid and its inhibitory effect on tumor growth in systemic malignancies: an emerging concept in oncology.

Future Oncol. 2013 May;9(5):627-8.
PMID: 23647290 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid (AKBA) inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway.

Biochim Biophys Acta. 2013 Jun;1830(6):3604-15.
PMID: 23500016 [PubMed - indexed for MEDLINE]


Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model.

BMC Complement Altern Med. 2012 Dec;12():253.
PMID: 23237355 [PubMed - indexed for MEDLINE]


Enhanced anticancer potential of encapsulated solid lipid nanoparticles of TPD: a novel triterpenediol from Boswellia serrata.

Mol Pharm. 2013 Jan;10(1):225-35.
PMID: 23237302 [PubMed - indexed for MEDLINE]


A novel semisynthetic inhibitor of the FRB domain of mammalian target of rapamycin blocks proliferation and triggers apoptosis in chemoresistant prostate cancer cells.

Mol Pharmacol. 2013 Feb;83(2):531-41.
PMID: 23208958 [PubMed - indexed for MEDLINE]


NF-κB down-regulation and PARP cleavage by novel 3-α-butyryloxy-β-boswellic acid results in cancer cell specific apoptosis and in vivo tumor regression.

Anticancer Agents Med Chem. 2013 Jun;13(5):777-90.
PMID: 23157593 [PubMed - indexed for MEDLINE]


Chemoprevention of intestinal adenomatous polyposis by acetyl-11-keto-beta-boswellic acid in APC(Min/+) mice.

Int J Cancer. 2013 Jun;132(11):2667-81.
PMID: 23132636 [PubMed - indexed for MEDLINE]


Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family.

Carcinogenesis. 2012 Dec;33(12):2441-9.
PMID: 22983985 [PubMed - indexed for MEDLINE]


PARP cleavage and perturbance in mitochondrial membrane potential by 3-α-propionyloxy-β-boswellic acid results in cancer cell death and tumor regression in murine models.

Future Oncol. 2012 Jul;8(7):867-81.
PMID: 22830406 [PubMed - indexed for MEDLINE]


Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells.

Cancer Biol Ther. 2012 May;13(7):542-52.
PMID: 22415137 [PubMed - indexed for MEDLINE]


[Chemopreventive effect of boswellic acid and curcumin on 7,12-dimethyl benzanthracene-induced hamster cheek pouch carcinogenesis].

Zhonghua Kou Qiang Yi Xue Za Zhi. 2011 Nov;46(11):678-83.
PMID: 22333308 [PubMed - indexed for MEDLINE]


Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells.

BMC Complement Altern Med. 2011 Dec;11():129.
PMID: 22171782 [PubMed - indexed for MEDLINE]


Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.

PLoS One. 2011;6(10):e26943.
PMID: 22066019 [PubMed - indexed for MEDLINE]


Targeting Sp1 transcription factors in prostate cancer therapy.

Med Chem. 2011 Sep;7(5):518-25.
PMID: 22022994 [PubMed - indexed for MEDLINE]


Potentiation of the antitumor effect of 11-keto-β-boswellic acid by its 3-α-hexanoyloxy derivative.

Eur J Pharmacol. 2011 Oct;668(3):390-400.
PMID: 21821018 [PubMed - indexed for MEDLINE]


A novel cyano derivative of 11-keto-β-boswellic acid causes apoptotic death by disrupting PI3K/AKT/Hsp-90 cascade, mitochondrial integrity, and other cell survival signaling events in HL-60 cells.

Mol Carcinog. 2012 Sep;51(9):679-95.
PMID: 21751262 [PubMed - indexed for MEDLINE]


Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers.

Int J Cancer. 2012 May;130(9):2176-84.
PMID: 21702037 [PubMed - indexed for MEDLINE]


Growth inhibitory, apoptotic and anti-inflammatory activities displayed by a novel modified triterpenoid, cyano enone of methyl boswellates.

J Biosci. 2011 Jun;36(2):297-307.
PMID: 21654084 [PubMed - indexed for MEDLINE]


Antitumor properties of Boswellic acid against Ehrlich ascites cells bearing mouse.

Food Chem Toxicol. 2011 Sep;49(9):1924-34.
PMID: 21513768 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression.

Int J Cancer. 2011 Jul;129(1):23-33.
PMID: 21448932 [PubMed - indexed for MEDLINE]


A cyano analogue of boswellic acid induces crosstalk between p53/PUMA/Bax and telomerase that stages the human papillomavirus type 18 positive HeLa cells to apoptotic death.

Eur J Pharmacol. 2011 Jun;660(2-3):241-8.
PMID: 21440536 [PubMed - indexed for MEDLINE]


A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid.

Eur J Med Chem. 2011 Apr;46(4):1356-66.
PMID: 21334793 [PubMed - indexed for MEDLINE]


[Effect of acetyl-11-keto-β-boswellic acid on proliferation, apoptosis and cell cycle of human acute myeloid leukemia cell line HL-60].

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Dec;18(6):1440-4.
PMID: 21176347 [PubMed - indexed for MEDLINE]


[Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1].

Zhong Xi Yi Jie He Xue Bao. 2010 Nov;8(11):1060-9.
PMID: 21078271 [PubMed - indexed for MEDLINE]


A propionyloxy derivative of 11-keto-β-boswellic acid induces apoptosis in HL-60 cells mediated through topoisomerase I & II inhibition.

Chem Biol Interact. 2011 Jan;189(1-2):60-71.
PMID: 21056033 [PubMed - indexed for MEDLINE]


Synthesis of an antitumor active endoperoxide from 11-keto-beta-boswellic acid.

Eur J Med Chem. 2010 Sep;45(9):3840-3.
PMID: 20538386 [PubMed - indexed for MEDLINE]


Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer.

Invest New Drugs. 2011 Oct;29(5):1081-9.
PMID: 20437079 [PubMed - indexed for MEDLINE]


[Cembrane diterpenes in olibanum].

Zhongguo Zhong Yao Za Zhi. 2009 Oct;34(19):2477-80.
PMID: 20067017 [PubMed - indexed for MEDLINE]


Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells.

Mol Pharmacol. 2010 Mar;77(3):378-87.
PMID: 20018812 [PubMed - indexed for MEDLINE]


Boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells.

Lipids Health Dis. 2009 Dec;8():51.
PMID: 19951413 [PubMed - indexed for MEDLINE]


LY294002 enhances boswellic acid-induced apoptosis in colon cancer cells.

Anticancer Res. 2009 Aug;29(8):2987-91.
PMID: 19661305 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis.

Cancer Res. 2009 Jul;69(14):5893-900.
PMID: 19567671 [PubMed - indexed for MEDLINE]


Activation of p53/p21/PUMA alliance and disruption of PI-3/Akt in multimodal targeting of apoptotic signaling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata.

Mol Carcinog. 2009 Dec;48(12):1093-108.
PMID: 19544329 [PubMed - indexed for MEDLINE]


Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island Soqotra.

BMC Complement Altern Med. 2009 Mar;9():7.
PMID: 19320966 [PubMed - indexed for MEDLINE]


Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity.

BMC Complement Altern Med. 2009 Mar;9():6.
PMID: 19296830 [PubMed - indexed for MEDLINE]


Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.

Mol Cancer Res. 2009 Jan;7(1):118-28.
PMID: 19147543 [PubMed - indexed for MEDLINE]


Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity.

Tetrahedron. 2008 Dec;64(51):11541-11548.
PMID: 20622928 [PubMed - as supplied by publisher]


Bosellia serrata-induced apoptosis is related with ER stress and calcium release.

Genes Nutr. 2008 Feb;2(4):371-4.
PMID: 18850233 [PubMed - as supplied by publisher]


In vitro screening for the tumoricidal properties of international medicinal herbs.

Phytother Res. 2009 Mar;23(3):385-98.
PMID: 18844256 [PubMed - indexed for MEDLINE]


Inhibitory effect of acetyl-11-keto-beta-boswellic acid on androgen receptor by interference of Sp1 binding activity in prostate cancer cells.

Biochem Pharmacol. 2008 Jun;75(11):2112-21.
PMID: 18430409 [PubMed - indexed for MEDLINE]


Comparison of the irritation potentials of Boswellia serrata gum resin and of acetyl-11-keto-beta-boswellic acid by in vitro cytotoxicity tests on human skin-derived cell lines.

Toxicol Lett. 2008 Mar;177(2):144-9.
PMID: 18304763 [PubMed - indexed for MEDLINE]


Acetyl-keto-beta-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells.

Cancer Res. 2008 Feb;68(4):1180-6.
PMID: 18281494 [PubMed - indexed for MEDLINE]


Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids.

Bioorg Med Chem Lett. 2007 Dec;17(23):6411-6.
PMID: 17950603 [PubMed - indexed for MEDLINE]


A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells.

Apoptosis. 2007 Oct;12(10):1911-26.
PMID: 17636381 [PubMed - indexed for MEDLINE]


Effect of acetyl 11-keto beta-boswellic acid on metastatic growth factor responsible for angiogenesis.

Vascul Pharmacol. 2007 May;46(5):333-7.
PMID: 17257903 [PubMed - indexed for MEDLINE]


Characterization of 3alpha-acetyl-11-keto-alpha-boswellic acid, a pentacyclic triterpenoid inducing apoptosis in vitro and in vivo.

Planta Med. 2006 Nov;72(14):1285-9.
PMID: 17022003 [PubMed - indexed for MEDLINE]


A lipoxygenase inhibitor in breast cancer brain metastases.

J Neurooncol. 2007 Mar;82(1):91-3.
PMID: 17001517 [PubMed - indexed for MEDLINE]


Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri.

Biol Pharm Bull. 2006 Sep;29(9):1976-9.
PMID: 16946522 [PubMed - indexed for MEDLINE]


Acetyl-keto-beta-boswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells.

Br J Pharmacol. 2006 Aug;148(8):1099-107.
PMID: 16783403 [PubMed - indexed for MEDLINE]


Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells.

Mol Cancer Ther. 2005 Mar;4(3):381-8.
PMID: 15767547 [PubMed - indexed for MEDLINE]


Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo.

J Biol Chem. 2005 Feb;280(7):6170-80.
PMID: 15576374 [PubMed - indexed for MEDLINE]


Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase.

Anticancer Res. 2003 Jul-Aug;23(4):3317-22.
PMID: 12926069 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-beta-boswellic acid (AKBA) is cytotoxic for meningioma cells and inhibits phosphorylation of the extracellular-signal regulated kinase 1 and 2.

Adv Exp Med Biol. 2002;507():387-93.
PMID: 12664615 [PubMed - indexed for MEDLINE]


Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells.

Cancer Detect Prev. 2003;27(1):67-75.
PMID: 12600419 [PubMed - indexed for MEDLINE]


Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro.

Anticancer Res. 2002 Sep-Oct;22(5):2853-62.
PMID: 12530009 [PubMed - indexed for MEDLINE]


Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells.

Carcinogenesis. 2002 Dec;23(12):2087-93.
PMID: 12507932 [PubMed - indexed for MEDLINE]


Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway.

Int J Mol Med. 2002 Oct;10(4):501-5.
PMID: 12239601 [PubMed - indexed for MEDLINE]


[Experimental study on Jurkat cell apoptosis induced by Boswellia carterii Birdw extractive].

Hunan Yi Ke Da Xue Xue Bao. 2000 Jun;25(3):241-4.
PMID: 12212153 [PubMed - indexed for MEDLINE]


Cytotoxic action of acetyl-11-keto-beta-boswellic acid (AKBA) on meningioma cells.

Planta Med. 2002 May;68(5):397-401.
PMID: 12058313 [PubMed - indexed for MEDLINE]


[Experimental study on induction of apoptosis of leukemic cells by Boswellia carterii Birdw extractive].

Hunan Yi Ke Da Xue Xue Bao. 1999;24(1):23-5.
PMID: 11938731 [PubMed - indexed for MEDLINE]


Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid.

Biofactors. 2000;13(1-4):225-30.
PMID: 11237186 [PubMed - indexed for MEDLINE]


Boswellic acids inhibit glioma growth: a new treatment option?

J Neurooncol. 2000;46(2):97-103.
PMID: 10894362 [PubMed - indexed for MEDLINE]


Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity.

Br J Cancer. 1999 May;80(5-6):756-65.
PMID: 10360653 [PubMed - indexed for MEDLINE]


Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines.

Leuk Res. 1999 Jan;23(1):43-50.
PMID: 9933134 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I.

J Pharmacol Exp Ther. 1999 Feb;288(2):613-9.
PMID: 9918566 [PubMed - indexed for MEDLINE]


Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture.

Planta Med. 1998 May;64(4):328-31.
PMID: 9619114 [PubMed - indexed for MEDLINE]


Recent progress in the study of anticancer drugs originating from plants and traditional medicines in China.

Chin Med Sci J. 1994 Mar;9(1):61-9.
PMID: 7916218 [PubMed - indexed for MEDLINE]


Highlight on the studies of anticancer drugs derived from plants in China.

Stem Cells. 1994 Jan;12(1):53-63.
PMID: 8142920 [PubMed - indexed for MEDLINE]


[Combination induction of cell differentiation of HL-60 cells by daidzein (S86019) and BC-4 or Ara-C].

Yao Xue Xue Bao. 1993;28(1):11-6.
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