8.3 Tumore

Der erste Bericht über eine Antitumoraktiviträt von Extrakten von Boswellia serrata stammt von Jing und Mitarbeitern (1992) unter Verwendung von menschlichen HL 60 Leukämiezellen.

Untersuchungen, die 1999 in Tübingen durchgeführt wurden, zeigten ebenfalls eine Antitumorwirkung bei HL 60 Leukämiezellen sowie bei Glioblastomzellen. Es stellte sich jedoch bei all diesen Untersuchungen heraus, dass die in vitro verwendeten Konzentrationen von Boswelliaextrakten und Boswelliasäuren, die zur Hemmung des Tumorwachstums notwendig waren, wesentlich höher lagen als diejenigen, die eine Hemmung der Leukotriensynthese in Leukozyten bewirkten, wie dies auch aus der Tabelle hervorgeht. Andererseits ist es jedoch denkbar, dass niedrigere Konzentrationen von Boswelliasäuren bei solchen Tumoren wirksam sein könnten, die eng mit einer erhöhten Bildung von Leukotrien verbunden sind.

Hier einige Daten aus dem Tübinger Institut:




Anti-proliferative, Pro-apoptotic, and Chemosensitizing Potential of 3-Acetyl-11-keto-β-boswellic Acid (AKBA) Against Prostate Cancer Cells.
Verma M, Fatima S, Saeed M, Ansari IA

Mol Biotechnol. 2024 Mar;():.
PMID: 38502429 [PubMed - as supplied by publisher]


Innovative microwave-assisted biosynthesis of copper oxide nanoparticles loaded with platinum(ii) based complex for halting colon cancer: cellular, molecular, and computational investigations.
Sedky NK, Fawzy IM, Hassan A, Mahdy NK, Attia RT, Shamma SN, Alfaifi MY, Elbehairi SE, Mokhtar FA, Fahmy SA

RSC Adv. 2024 Jan;14(6):4005-4024.
PMID: 38288146 [PubMed - as supplied by publisher]


Boswellic acid formulations are not suitable for treatment of pediatric high-grade glioma due to tumor promoting potential.
Wiese M, Pohlmeier B, Kubiak K, El-Khouly FE, Sitte M, Carcaboso AM, Baugh JN, Perwein T, Nussbaumer G, Karremann M, Gielen GH, Salinas G, Kramm CM

J Tradit Complement Med. 2024 Jan;14(1):101-108.
PMID: 38223806 [PubMed - as supplied by publisher]


The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer.
Valente IVB, Garcia D, Abbott A, Spruill L, Siegel J, Forcucci J, Hanna G, Mukherjee R, Hamann M, Hilliard E, Lockett M, Cole DJ, Klauber-DeMore N

Breast Cancer Res Treat. 2024 Apr;204(3):521-530.
PMID: 38194131 [PubMed - indexed for MEDLINE]


oleoresin extracts induce caspase-mediated apoptosis and G cell cycle arrest in human leukaemia subtypes.
Jones MA, Borun A, Greensmith DJ

Front Pharmacol. 2023;14():1282239.
PMID: 38155908 [PubMed - as supplied by publisher]


Component Composition and Biological Activity of Oleo-Gum Resin from Boswellia serrata (Burseraceae).
Cherepanova MO, Subotyalov MA

Dokl Biol Sci. 2023 Oct;512(1):336-342.
PMID: 38087024 [PubMed - indexed for MEDLINE]


S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome.
Yang YH, Li W, Ren LW, Yang H, Zhang YZ, Zhang S, Hao Y, Yu DK, Tong RS, Du GH, Shi JY, Wang JH

Acta Pharmacol Sin. 2024 Jan;45(1):209-222.
PMID: 37749236 [PubMed - indexed for MEDLINE]


Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent.
Trivedi VL, Soni R, Dhyani P, Sati P, Tejada S, Sureda A, Setzer WN, Faizal Abdull Razis A, Modu B, Butnariu M, Sharifi-Rad J

Front Pharmacol. 2023;14():1187181.
PMID: 37601048 [PubMed - as supplied by publisher]


Anti-cancer effect of nano-encapsulated boswellic acids, curcumin and naringenin against HepG-2 cell line.
Elnawasany S, Haggag YA, Shalaby SM, Soliman NA, El Saadany AA, Ibrahim MAA, Badria F

BMC Complement Med Ther. 2023 Jul;23(1):270.
PMID: 37516826 [PubMed - indexed for MEDLINE]


Antiproliferative and cell cycle arrest potentials of 3-O-acetyl-11-keto-β-boswellic acid against MCF-7 cells in vitro.
Ahmed SA, Al-Shanon AF, Al-Saffar AZ, Tawang A, Al-Obaidi JR

J Genet Eng Biotechnol. 2023 Jul;21(1):75.
PMID: 37393563 [PubMed - as supplied by publisher]


Natural Anticancer Agents: Their Therapeutic Potential, Challenges,s and Promising Outcomes.
Tauro S, Dhokchawle B, Mohite P, Nahar D, Nadar S, Coutinho E

Curr Med Chem. 2023 May;():.
PMID: 37138435 [PubMed - as supplied by publisher]


Metabolomics-based discovery of XHP as a CYP3A4 inhibitor against pancreatic cancer.
Yang Y, Guo Y, Luo H, Wang M, Chen F, Cui H, Chen P, Yin Z, Li L, Dai Y, Zeng J, Zhao J

Front Pharmacol. 2023;14():1164827.
PMID: 37081969 [PubMed - as supplied by publisher]


ADME Prediction, Structure-activity Relationship of Boswellic Acid Scaffold for the Aspect of Anticancer & Anti-inflammatory Potency.
Kumar A, Sharma S, Mishra S, Ojha S, Upadhyay P

Anticancer Agents Med Chem. 2023;23(13):1499-1505.
PMID: 37070442 [PubMed - indexed for MEDLINE]


[Comparison of in vivo plasma pharmacokinetics and urine excretion of main components in Xihuang Formula in rats with precancerous lesions of breast cancer].
Xie JX, Zhang YJ, Huang PW, Zhang YT, Wang Z, Feng NP

Zhongguo Zhong Yao Za Zhi. 2023 Mar;48(6):1642-1651.
PMID: 37005852 [PubMed - indexed for MEDLINE]


Essential Oils Extracted from Oleo Gum Resin Loaded into PLGA-PCL Nanoparticles: Enhanced Cytotoxic and Apoptotic Effects against Breast Cancer Cells.
Azzazy HME, Abdelnaser A, Al Mulla H, Sawy AM, Shamma SN, Elhusseiny M, Alwahibi S, Mahdy NK, Fahmy SA

ACS Omega. 2023 Jan;8(1):1017-1025.
PMID: 36643489 [PubMed - as supplied by publisher]


Synergistic Effect of HAD-B1 and Afatinib Against Gefitinib Resistance of Non-Small Cell Lung Cancer.
Song SY, Park JH, Park SJ, Kang IC, Yoo HS

Integr Cancer Ther. 2022;21():15347354221144311.
PMID: 36565160 [PubMed - indexed for MEDLINE]


Comparative study of the cytotoxicity, apoptotic, and epigenetic effects of Boswellic acid derivatives on breast cancer.
Jamshidi-Adegani F, Ghaemi S, Al-Hashmi S, Vakilian S, Al-Kindi J, Rehman NU, Alam K, Al-Riyami K, Csuk R, Arefian E, Al-Harrasi A

Sci Rep. 2022 Nov;12(1):19979.
PMID: 36411309 [PubMed - indexed for MEDLINE]


AKBA inhibits radiotherapy resistance in lung cancer by inhibiting maspin methylation and regulating the AKT/FOXO1/p21 axis.
Gong C, Li W, Wu J, Li YY, Ma Y, Tang LW

J Radiat Res. 2023 Jan;64(1):33-43.
PMID: 36300343 [PubMed - indexed for MEDLINE]


Anti-proliferative tirucallane triterpenoids from gum resin of Boswellia sacra.
Zhang B, Liu D, Cao S, Yao T, Liu G, Chen L, Qiu F

Bioorg Chem. 2022 Dec;129():106155.
PMID: 36209562 [PubMed - indexed for MEDLINE]


Retraction: Boswellic Acid Suppresses Growth and Metastasis of Human Pancreatic Tumors in an Orthotopic Nude Mouse Model through Modulation of Multiple Targets.

PLoS One. 2022;17(9):e0275582.
PMID: 36170284 [PubMed - as supplied by publisher]


Selective anti-cancer activity against melanoma cells using 3--acetyl-β-boswellic acid-loaded 3D-Printed scaffold.
Jamshidi-Adegani F, Vakilian S, Al-Hashmi S, Al-Kindi J, Rehman NU, Al-Sinani Y, Ghaemi S, Alam K, Anwar MU, Csuk R, Al-Harrasi A

Nat Prod Res. 2023 Jun;37(12):2049-2054.
PMID: 36008779 [PubMed - indexed for MEDLINE]


Correction: 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.
Li W, Liu J, Fu W, Zheng X, Ren L, Liu S, Wang J, Ji T, Du G

J Exp Clin Cancer Res. 2022 Aug;41(1):236.
PMID: 35918768 [PubMed - as supplied by publisher]


β-Boswellic Acid Suppresses Breast Precancerous Lesions GLUT1 Targeting-Mediated Glycolysis Inhibition and AMPK Pathway Activation.
Bie F, Zhang G, Yan X, Ma X, Zhan S, Qiu Y, Cao J, Ma Y, Ma M

Front Oncol. 2022;12():896904.
PMID: 35712503 [PubMed - as supplied by publisher]


Phytotherapy in Integrative Oncology-An Update of Promising Treatment Options.
Zimmermann-Klemd AM, Reinhardt JK, Winker M, Gründemann C

Molecules. 2022 May;27(10):.
PMID: 35630688 [PubMed - indexed for MEDLINE]


Bioactive Evaluation of Ursane-Type Pentacyclic Triterpenoids: -Boswellic Acid Interferes with the Glycosylation and Transport of Intercellular Adhesion Molecule-1 in Human Lung Adenocarcinoma A549 Cells.
Nakano K, Sasaki S, Kataoka T

Molecules. 2022 May;27(10):.
PMID: 35630550 [PubMed - indexed for MEDLINE]


2-Pyridin-4-yl-methylene-beta-boswellic Acid-A Potential Candidate for Targeting O-Methylguanine-DNA Methyltransferase Epi-transcriptional Reprogramming in KRAS G13D-Microsatellite Stable, G12V-Microsatellite Instable Mutant Colon Cancer.
Qayum A, Singh J, Kumar A, Shah SM, Srivastava S, Kushwaha M, Magotra A, Nandi U, Malik R, Shah BA, Singh SK

ACS Pharmacol Transl Sci. 2022 May;5(5):306-320.
PMID: 35592435 [PubMed - as supplied by publisher]


Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway.
Teng YJ, Deng Z, Ouyang ZG, Zhou Q, Mei S, Fan XX, Wu YR, Long HP, Fang LY, Yin DL, Zhang BY, Guo YM, Zhu WH, Huang Z, Zheng P, Ning DM, Tian XF

World J Gastrointest Oncol. 2022 Apr;14(4):872-886.
PMID: 35582102 [PubMed - as supplied by publisher]


Synergistic combination of PMBA and 5-fluorouracil (5-FU) in targeting mutant KRAS in 2D and 3D colorectal cancer cells.
Qayum A, Magotra A, Shah SM, Nandi U, Sharma PR, Shah BA, Singh SK

Heliyon. 2022 Apr;8(4):e09103.
PMID: 35445157 [PubMed - as supplied by publisher]


Protective role of AKBA against benzo(a)pyrene-induced lung carcinogenesis by modulating biotransformation enzymes and oxidative stress.
Bhardwaj P, Kumar M, Dhatwalia SK, Garg ML, Dhawan DK

J Biochem Mol Toxicol. 2022 Jul;36(7):e23072.
PMID: 35437857 [PubMed - indexed for MEDLINE]


Synthesis of 3--Acetyl-11-keto-β-boswellic Acid (AKBA)-Derived Amides and Their Mitochondria-Targeted Antitumor Activities.
Li C, He Q, Xu Y, Lou H, Fan P

ACS Omega. 2022 Mar;7(11):9853-9866.
PMID: 35350335 [PubMed - as supplied by publisher]


Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways.
Zheng P, Huang Z, Tong DC, Zhou Q, Tian S, Chen BW, Ning DM, Guo YM, Zhu WH, Long Y, Xiao W, Deng Z, Lei YC, Tian XF

World J Gastrointest Oncol. 2022 Feb;14(2):450-477.
PMID: 35317323 [PubMed - as supplied by publisher]


Molecular evidences on anti-inflammatory, anticancer, and memory-boosting effects of frankincense.
Khajehdehi M, Khalaj-Kondori M, Baradaran B

Phytother Res. 2022 Mar;36(3):1194-1215.
PMID: 35142408 [PubMed - indexed for MEDLINE]


Review of the Chemical Composition, Pharmacological Effects, Pharmacokinetics, and Quality Control of .
Huang K, Chen Y, Liang K, Xu X, Jiang J, Liu M, Zhou F

Evid Based Complement Alternat Med. 2022;2022():6627104.
PMID: 35069765 [PubMed - as supplied by publisher]


Five terpenoids from the gum resin of Boswellia carterii and their cytotoxicity.
Feng Y, Zhang Q, Sun L

Fitoterapia. 2021 Oct;154():105017.
PMID: 34418492 [PubMed - indexed for MEDLINE]


Chloroform extract and acetyl-11-keto-beta-boswellic acid from Boswellia dalzielii stem bark induce apoptosis and cell cycle blockage in AW8507 cells.
Otitoju AP, Longdet IY, Alemika TE, Gota VP

J Egypt Natl Canc Inst. 2021 Aug;33(1):20.
PMID: 34368899 [PubMed - indexed for MEDLINE]


An engineered microfluidic blood-brain barrier model to evaluate the anti-metastatic activity of β-boswellic acid.
Vakilian S, Alam K, Al-Kindi J, Jamshidi-Adegani F, Rehman NU, Tavakoli R, Al-Riyami K, Hasan A, Zadjali F, Csuk R, Al-Harrasi A, Al-Hashmi S

Biotechnol J. 2021 Oct;16(10):e2100044.
PMID: 34313388 [PubMed - indexed for MEDLINE]


Prenylaromadendrane-type diterpenoids from the gum resin of flueck and their cytotoxic effects.
Wang JJ, Suo XY, Sun HR, Wang X, Lin MB, Wang JH, Jiang JD, Ji TF

Nat Prod Res. 2022 Nov;36(21):5400-5406.
PMID: 34121549 [PubMed - indexed for MEDLINE]


Molecular insight into isoform specific inhibition of PI3K-α and PKC-η with dietary agents through an ensemble pharmacophore and docking studies.
Bhaskar BV, Rammohan A, Babu TM, Zheng GY, Chen W, Rajendra W, Zyryanov GV, Gu W

Sci Rep. 2021 Jun;11(1):12150.
PMID: 34108504 [PubMed - indexed for MEDLINE]


[One new cembranoid diterpene from gum resin of Boswellia carterii].
Xia H, Wang CC, Wang RY, Liang NY, Wang XY, Song YL, Zhao YF, Huo HX, Li J

Zhongguo Zhong Yao Za Zhi. 2021 May;46(9):2215-2219.
PMID: 34047123 [PubMed - indexed for MEDLINE]


Ameliorative Effects of Boswellic Acid on Fipronil-Induced Toxicity: Antioxidant State, Apoptotic Markers, and Testicular Steroidogenic Expression in Male Rats.
Tohamy HG, El-Kazaz SE, Alotaibi SS, Ibrahiem HS, Shukry M, Dawood MAO

Animals (Basel). 2021 Apr;11(5):.
PMID: 33946602 [PubMed - as supplied by publisher]


Complementary and alternative medicine in children with diffuse intrinsic pontine glioma-A SIOPE DIPG Network and Registry study.
El-Khouly FE, Adil SM, Wiese M, Hulleman E, Hendrikse NH, Kaspers GJL, Kramm CM, Veldhuijzen van Zanten SEM, van Vuurden DG,

Pediatr Blood Cancer. 2021 Sep;68(9):e29061.
PMID: 33942498 [PubMed - indexed for MEDLINE]


A protein-sulfosalicylic acid/boswellic acids @metal-organic framework nanocomposite as anticancer drug delivery system.
Özsoy M, Atiroğlu V, Guney Eskiler G, Atiroğlu A, Deveci Ozkan A, Özacar M

Colloids Surf B Biointerfaces. 2021 Aug;204():111788.
PMID: 33932885 [PubMed - indexed for MEDLINE]


Mechanisms exploration of Xiaojin Pills on lung cancer based on metabolomics and network pharmacology.
Cao B, Lin J, Wu Z, Liu H, Zhang D, Xu H, Xu R, Han L

J Pharm Pharmacol. 2021 Jul;73(8):1071-1079.
PMID: 33864464 [PubMed - indexed for MEDLINE]


Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via the induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway.
Wang D, Song SGJBY

J BUON. 2021;26(1):293.
PMID: 33721478 [PubMed - indexed for MEDLINE]


Boswellic acids: privileged structures to develop lead compounds for anticancer drug discovery.
Hussain H, Ali I, Wang D, Hakkim FL, Westermann B, Rashan L, Ahmed I, Green IR

Expert Opin Drug Discov. 2021 Aug;16(8):851-867.
PMID: 33650441 [PubMed - indexed for MEDLINE]


Role of Testosterone Levels on the Combinatorial Effect of Extract and Enzalutamide on Androgen Dependent LNCaP Cells and in Patient Derived Cells.
Pillai P, Pooleri GK, Nair SV

Integr Cancer Ther. 2021;20():1534735421996824.
PMID: 33615860 [PubMed - indexed for MEDLINE]


Simultaneous determination of five bioactive components of XiaoJin Capsule in normal and mammary gland hyperplasia rat plasma using LC-MS/MS and its application to a pharmacokinetic study.
Wang X, Lei H, Qi X, Guo X, Xu X, Zu X, Ye J

Biomed Chromatogr. 2021 Mar;35(3):e5000.
PMID: 33460195 [PubMed - indexed for MEDLINE]


11-Keto-α-Boswellic Acid, a Novel Triterpenoid from spp. with Chemotaxonomic Potential and Antitumor Activity against Triple-Negative Breast Cancer Cells.
Schmiech M, Ulrich J, Lang SJ, Büchele B, Paetz C, St-Gelais A, Syrovets T, Simmet T

Molecules. 2021 Jan;26(2):.
PMID: 33445710 [PubMed - indexed for MEDLINE]


Phyto-Facilitated Bimetallic ZnFeO Nanoparticles via Boswellia carteri: Synthesis, Characterization, and Anti-Cancer Activity.
Imraish A, Al-Hunaiti A, Abu-Thiab T, Ibrahim AA, Hwaitat E, Omar A

Anticancer Agents Med Chem. 2021;21(13):1767-1772.
PMID: 33342418 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway.
Sun MX, He XP, Huang PY, Qi Q, Sun WH, Liu GS, Hua J

World J Gastroenterol. 2020 Oct;26(38):5822-5835.
PMID: 33132637 [PubMed - indexed for MEDLINE]


Antiproliferative effects of boswellic acid-loaded chitosan nanoparticles on human lung cancer cell line A549.
Solanki N, Mehta M, Chellappan DK, Gupta G, Hansbro NG, Tambuwala MM, Aa Aljabali A, Paudel KR, Liu G, Satija S, Hansbro PM, Dua K, Dureja H

Future Med Chem. 2020 Nov;12(22):2019-2034.
PMID: 33124483 [PubMed - indexed for MEDLINE]


-Mediated Silver Nanoparticles Inhibited Acute Myeloid Leukemia (AML) Kasumi-1 Cells by Inducing Cell Cycle Arrest.
Adebayo IA, Usman AI, Shittu FB, Ismail NZ, Arsad H, Muftaudeen TK, Samian MR

Bioinorg Chem Appl. 2020;2020():8898360.
PMID: 33029114 [PubMed - as supplied by publisher]


Boswellic acid sensitizes gastric cancer cells to Cisplatin-induced apoptosis via p53-mediated pathway.
Al-Bahlani S, Burney IA, Al-Dhahli B, Al-Kharusi S, Al-Kharousi F, Al-Kalbani A, Ahmed I

BMC Pharmacol Toxicol. 2020 Sep;21(1):64.
PMID: 32867831 [PubMed - indexed for MEDLINE]


Exploring the Regulation Mechanism of Xihuang Pill, and β-Boswellic Acid on the Biomolecular Network of Triple-Negative Breast Cancer Based on Transcriptomics and Chemical Informatics Methodology.
Yang K, Zeng L, Ge A, Bao T, Xu T, Xie X, Liu L

Front Pharmacol. 2020;11():825.
PMID: 32595497 [PubMed - as supplied by publisher]


Acetyl-11-keto-β-boswellic acid enhances the cisplatin sensitivity of non-small cell lung cancer cells through cell cycle arrest, apoptosis induction, and autophagy suppression via p21-dependent signaling pathway.
Lv M, Zhuang X, Zhang Q, Cheng Y, Wu D, Wang X, Qiao T

Cell Biol Toxicol. 2021 Apr;37(2):209-228.
PMID: 32562082 [PubMed - indexed for MEDLINE]


Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model.
Girardi B, Pricci M, Giorgio F, Piazzolla M, Iannone A, Losurdo G, Principi M, Barone M, Ierardi E, Di Leo A

World J Gastroenterol. 2020 Apr;26(14):1601-1612.
PMID: 32327909 [PubMed - indexed for MEDLINE]


Frankincense and myrrh and their bioactive compounds ameliorate the multiple myeloma through regulation of metabolome profiling and JAK/STAT signaling pathway based on U266 cells.
Gao R, Miao X, Sun C, Su S, Zhu Y, Qian D, Ouyang Z, Duan J

BMC Complement Med Ther. 2020 Mar;20(1):96.
PMID: 32293402 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic Acid Inhibits Precancerous Breast Lesion MCF-10AT Cells via Regulation of LINC00707/miR-206 that Reduces Estrogen Receptor-α.
Jiang X, Liu Y, Zhang G, Lin S, Yuan N, Wu J, Yan X, Ma Y, Ma M

Cancer Manag Res. 2020;12():2301-2314.
PMID: 32273767 [PubMed - as supplied by publisher]


Acetyl-11-Keto-β-Boswellic Acid Exerts the Anti-Cancer Effects via Cell Cycle Arrest, Apoptosis Induction and Autophagy Suppression in Non-Small Cell Lung Cancer Cells.
Lv M, Shao S, Zhang Q, Zhuang X, Qiao T

Onco Targets Ther. 2020;13():733-744.
PMID: 32158225 [PubMed - as supplied by publisher]


β-Elemonic acid inhibits the growth of human Osteosarcoma through endoplasmic reticulum (ER) stress-mediated PERK/eIF2α/ATF4/CHOP activation and Wnt/β-catenin signal suppression.
Zhao A, Zhang Z, Zhou Y, Li X, Li X, Ma B, Zhang Q

Phytomedicine. 2020 Apr;69():153183.
PMID: 32113150 [PubMed - indexed for MEDLINE]


3--Acetyl-11-keto- -boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma.
Li W, Ren L, Zheng X, Liu J, Wang J, Ji T, Du G

Acta Pharm Sin B. 2020 Feb;10(2):301-312.
PMID: 32082975 [PubMed - as supplied by publisher]


Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities.
Efferth T, Oesch F

Semin Cancer Biol. 2022 May;80():39-57.
PMID: 32027979 [PubMed - indexed for MEDLINE]


Fractions of Suppress LTA, LTC, Cyclooxygenase-2 Activities and mRNA in HL-60 Cells and Reduce Lung Inflammation in BALB/c Mice.
Soni KK, Meshram D, Lawal TO, Patel U, Mahady GB

Curr Drug Discov Technol. 2021;18(1):95-104.
PMID: 31985381 [PubMed - indexed for MEDLINE]


Cembrane-type diterpenoids from the gum resin of and their biological activities.
Sun X, Geng Y, Wang X, Qin D, Yu J

RSC Adv. 2020 Jan;10(2):746-755.
PMID: 35494443 [PubMed - as supplied by publisher]


Chemical Composition and in Vitro Cytotoxic Screening of Sixteen Commercial Essential Oils on Five Cancer Cell Lines.
Najar B, Shortrede JE, Pistelli L, Buhagiar J

Chem Biodivers. 2020 Jan;17(1):e1900478.
PMID: 31713998 [PubMed - indexed for MEDLINE]


Targeting Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1: A Structure-based Virtual Screening Approach to Find Novel Inhibitors.
da Costa KS, Galúcio JM, de Jesus DA, Gomes GC, Lima E Lima AH, Taube PS, Dos Santos AM, Lameira J

Curr Comput Aided Drug Des. 2020;16(5):605-617.
PMID: 31654518 [PubMed - indexed for MEDLINE]


Comparative Investigation of Frankincense Nutraceuticals: Correlation of Boswellic and Lupeolic Acid Contents with Cytokine Release Inhibition and Toxicity against Triple-Negative Breast Cancer Cells.
Schmiech M, Lang SJ, Ulrich J, Werner K, Rashan LJ, Syrovets T, Simmet T

Nutrients. 2019 Oct;11(10):.
PMID: 31581678 [PubMed - indexed for MEDLINE]


Practical Application of "About Herbs" Website: Herbs and Dietary Supplement Use in Oncology Settings.
Hou YN, Deng G, Mao JJ

Cancer J. 2019;25(5):357-366.
PMID: 31567464 [PubMed - indexed for MEDLINE]


α-Pinene Induces Apoptotic Cell Death via Caspase Activation in Human Ovarian Cancer Cells.
Hou J, Zhang Y, Zhu Y, Zhou B, Ren C, Liang S, Guo Y

Med Sci Monit. 2019 Sep;25():6631-6638.
PMID: 31482864 [PubMed - indexed for MEDLINE]


In evaluation of apoptogenic potential and toxicological profile of triterpenoids.
Desai TH, Joshi SV

Indian J Pharmacol. 2019;51(3):181-207.
PMID: 31391686 [PubMed - indexed for MEDLINE]


Bioactive cembrane-type diterpenoids from the gum-resin of Boswellia carterii.
Wang YG, Ren J, Ma J, Yang JB, Ji T, Wang AG

Fitoterapia. 2019 Sep;137():104263.
PMID: 31295512 [PubMed - indexed for MEDLINE]


Comparative Analysis of Pentacyclic Triterpenic Acid Compositions in Oleogum Resins of Different Species and Their In Vitro Cytotoxicity against Treatment-Resistant Human Breast Cancer Cells.
Schmiech M, Lang SJ, Werner K, Rashan LJ, Syrovets T, Simmet T

Molecules. 2019 Jun;24(11):.
PMID: 31181656 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid modulates membrane dynamics in benzo(a)pyrene-induced lung carcinogenesis.
Bhardwaj P, Kumar M, Dhatwalia SK, Garg ML, Dhawan DK

Mol Cell Biochem. 2019 Oct;460(1-2):17-27.
PMID: 31165316 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid triggers premature senescence via induction of DNA damage accompanied by impairment of DNA repair genes in hepatocellular carcinoma cells in vitro and in vivo.
Wang S, Wang H, Sun B, Li D, Wu J, Li J, Tian X, Qin C, Chang H, Liu Y

Fundam Clin Pharmacol. 2020 Feb;34(1):65-76.
PMID: 31141202 [PubMed - indexed for MEDLINE]


3-acetyl-11-keto-beta-boswellic acid decreases the malignancy of taxol resistant human ovarian cancer by inhibiting multidrug resistance (MDR) proteins function.
Jin L, Yingchun W, Zhujun S, Yinan W, Dongchen W, Hui Y, Xi Y, Wanzhou Z, Buluan Z, Jinhua W

Biomed Pharmacother. 2019 Aug;116():108992.
PMID: 31129513 [PubMed - indexed for MEDLINE]


An Approach to Treatment of Liver Cancer by Novel Glycyrrhizin Derivative.
El-Senduny FF, Zidane MM, Youssef MM, Badria FA

Anticancer Agents Med Chem. 2019;19(15):1863-1873.
PMID: 30973113 [PubMed - indexed for MEDLINE]


New derivatives of 11-keto-β-boswellic acid (KBA) induce apoptosis in breast and prostate cancers cells.
Bini Araba A, Ur Rehman N, Al-Araimi A, Al-Hashmi S, Al-Shidhani S, Csuk R, Hussain H, Al-Harrasi A, Zadjali F

Nat Prod Res. 2021 Mar;35(5):707-716.
PMID: 30931626 [PubMed - indexed for MEDLINE]


Boswellic acid has anti-inflammatory effects and enhances the anticancer activities of Temozolomide and Afatinib, an irreversible ErbB family blocker, in human glioblastoma cells.
Barbarisi M, Barbarisi A, De Sena G, Armenia E, Aurilio C, Libutti M, Iaffaioli RV, Botti G, Maurea N, Quagliariello V

Phytother Res. 2019 Jun;33(6):1670-1682.
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Interplay of non-coding RNAs and approved antimetabolites such as gemcitabine and pemetrexed in mesothelioma.
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Noncoding RNA Res. 2018 Dec;3(4):213-225.
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Relations between approved platinum drugs and non-coding RNAs in mesothelioma.
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Noncoding RNA Res. 2018 Dec;3(4):161-173.
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Synthesis of new boswellic acid derivatives as potential antiproliferative agents.
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Nat Prod Res. 2020 Jul;34(13):1845-1852.
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Boswellia frereana suppresses HGF-mediated breast cancer cell invasion and migration through inhibition of c-Met signalling.
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J Transl Med. 2018 Oct;16(1):281.
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Retraction: Boswellic Acid Blocks Signal Transducers and Activators of Transcription 3 Signaling, Proliferation, and Survival of Multiple Myeloma via the Protein Tyrosine Phosphatase SHP-1.

Mol Cancer Res. 2018 Sep;16(9):1444.
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Acetyl-11-keto-β-boswellic acid suppresses docetaxel-resistant prostate cancer cells in vitro and in vivo by blocking Akt and Stat3 signaling, thus suppressing chemoresistant stem cell-like properties.
Liu YQ, Wang SK, Xu QQ, Yuan HQ, Guo YX, Wang Q, Kong F, Lin ZM, Sun DQ, Wang RM, Lou HX

Acta Pharmacol Sin. 2019 May;40(5):689-698.
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Design, synthesis and biological evaluation of ring A modified 11-keto-boswellic acid derivatives as Pin1 inhibitors with remarkable anti-prostate cancer activity.
Huang M, Li A, Zhao F, Xie X, Li K, Jing Y, Liu D, Zhao L

Bioorg Med Chem Lett. 2018 Oct;28(19):3187-3193.
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Review of Common Alternative Herbal "Remedies" for Skin Cancer.
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Dermatol Surg. 2019 Jan;45(1):58-67.
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Chemoprevention of inflammation-related colorectal cancer by silymarin-, acetyl-11-keto-beta-boswellic acid-, curcumin- and maltodextrin-enriched dietetic formulation in animal model.
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Carcinogenesis. 2018 Oct;39(10):1274-1282.
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3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.
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J Exp Clin Cancer Res. 2018 Jul;37(1):132.
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Combined acetyl-11-keto-β-boswellic acid and radiation treatment inhibited glioblastoma tumor cells.
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PLoS One. 2018;13(7):e0198627.
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Homopiperazine-rhodamine B adducts of triterpenoic acids are strong mitocans.
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Eur J Med Chem. 2018 Jul;155():869-879.
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Inhibitory effect of 11-carbonyl-beta-boswellic acid on non-small cell lung cancer H446 cells.
Huang G, Yang J, Zhang L, Cao L, Zhang M, Niu X, Zhou Z, Zhang X, Li P, Liu JF

Biochem Biophys Res Commun. 2018 Sep;503(4):2202-2205.
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Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway.
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J BUON. 2018;23(2):340-345.
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Utilizing biomarkers in colorectal cancer: an interview with Ajay Goel.
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Future Oncol. 2017 Dec;13(28):2511-2514.
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Transcriptomic Profiling of MDA-MB-231 Cells Exposed to and 3-O-Acetyl-B-Boswellic Acid; ER/UPR Mediated Programmed Cell Death.
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Cancer Genomics Proteomics. 2017;14(6):409-425.
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Methanolic extract of Boswellia serrata exhibits anti-cancer activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells.
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Prostaglandins Other Lipid Mediat. 2017 Jul;131():1-8.
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P-gp modulatory acetyl-11-keto-β-boswellic acid based nanoemulsified carrier system for augmented oral chemotherapy of docetaxel.
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Colloids Surf B Biointerfaces. 2017 Jul;155():276-286.
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Boswellia serrata resin extract alleviates azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon tumorigenesis.
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Mol Nutr Food Res. 2017 Sep;61(9):.
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Design and synthesis of novel 2-substituted 11-keto-boswellic acid heterocyclic derivatives as anti-prostate cancer agents with Pin1 inhibition ability.
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Eur J Med Chem. 2017 Jan;126():910-919.
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Ring A-modified Derivatives from the Natural Triterpene 3-O-acetyl-11-keto-β-Boswellic Acid and their Cytotoxic Activity.
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Anticancer Agents Med Chem. 2017;17(8):1153-1167.
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Interplay between cell cycle and autophagy induced by boswellic acid analog.
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Sci Rep. 2016 Sep;6():33146.
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Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves.
Kohoude MJ, Gbaguidi F, Agbani P, Ayedoun MA, Cazaux S, Bouajila J

Pharm Biol. 2017 Dec;55(1):33-42.
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Therapeutic potential of boswellic acids: a patent review (1990-2015).
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Expert Opin Ther Pat. 2017 Jan;27(1):81-90.
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Role of angiogenic factors of herbal origin in regulation of molecular pathways that control tumor angiogenesis.
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Tumour Biol. 2016 Nov;37(11):14341-14354.
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Chemical composition, antiproliferative, antioxidant and antibacterial activities of essential oils from aromatic plants growing in Sudan.
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Asian Pac J Trop Med. 2016 Aug;9(8):763-70.
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Reversal of the multidrug resistance of human ileocecal adenocarcinoma cells by acetyl-11-keto-β-boswellic acid via downregulation of P-glycoprotein signals.
Xue X, Chen F, Liu A, Sun D, Wu J, Kong F, Luan Y, Qu X, Wang R

Biosci Trends. 2016 Nov;10(5):392-399.
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Improved efficacy of cisplatin in combination with a nano-formulation of pentacyclic triterpenediol.
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Mater Sci Eng C Mater Biol Appl. 2016 Nov;68():109-116.
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β-Boswellic acid, a bioactive substance used in food supplements, inhibits protein synthesis by targeting the ribosomal machinery.
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J Mass Spectrom. 2016 Sep;51(9):821-7.
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Boswellic acid disables signal transduction of IL-6-STAT-3 in Ehrlich ascites tumor bearing irradiated mice.
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Biochem Cell Biol. 2016 Aug;94(4):307-13.
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Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention.
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Noncoding RNA Res. 2016 Oct;1(1):12-34.
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Pharmacological evidences for cytotoxic and antitumor properties of Boswellic acids from Boswellia serrata.
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J Ethnopharmacol. 2016 Sep;191():315-323.
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Boswellic acid activity against glioblastoma stem-like cells.
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Oncol Lett. 2016 Jun;11(6):4187-4192.
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Frankincense--therapeutic properties.
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Postepy Hig Med Dosw (Online). 2016 Jan;70():380-91.
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The potential role of boswellic acids in cancer prevention and treatment.
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Cancer Lett. 2016 Jul;377(1):74-86.
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Use of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma.
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Dermatol Ther. 2016 Nov;29(6):393.
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Synthesis of β-boswellic acid derivatives as cytotoxic and apoptotic agents.
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Bioorg Med Chem Lett. 2016 Jan;26(1):76-81.
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Phytochemical Analysis and Anti-cancer Investigation of Boswellia serrata Bioactive Constituents In Vitro.
Ahmed HH, Abd-Rabou AA, Hassan AZ, Kotob SE

Asian Pac J Cancer Prev. 2015;16(16):7179-88.
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Triggering of Suicidal Erythrocyte Death Following Boswellic Acid Exposure.
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Cell Physiol Biochem. 2015;37(1):131-42.
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Combination of Anti-Diabetic Drug Metformin and Boswellic Acid Nanoparticles: A Novel Strategy for Pancreatic Cancer Therapy.
Snima KS, Nair RS, Nair SV, Kamath CR, Lakshmanan VK

J Biomed Nanotechnol. 2015 Jan;11(1):93-104.
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Boswellic acids synergize antitumor activity and protect against the cardiotoxicity of doxorubicin in mice bearing Ehrlich's carcinoma.
Ali SA, Zaitone SA, Moustafa YM

Can J Physiol Pharmacol. 2015 Aug;93(8):695-708.
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11-Keto-boswellic acid derived amides and monodesmosidic saponins induce apoptosis in breast and cervical cancers cells.
Csuk R, Barthel-Niesen A, Barthel A, Schäfer R, Al-Harrasi A

Eur J Med Chem. 2015 Jul;100():98-105.
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Synthesis and structure-activity relationships of boswellic acid derivatives as potent VEGFR-2 inhibitors.
Shen S, Xu X, Liu Z, Liu J, Hu L

Bioorg Med Chem. 2015 May;23(9):1982-93.
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Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer.
Toden S, Okugawa Y, Buhrmann C, Nattamai D, Anguiano E, Baldwin N, Shakibaei M, Boland CR, Goel A

Cancer Prev Res (Phila). 2015 May;8(5):431-43.
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Prediction of anticancer property of bowsellic acid derivatives by quantitative structure activity relationship analysis and molecular docking study.
Satpathy R, Guru RK, Behera R, Nayak B

J Pharm Bioallied Sci. 2015;7(1):21-5.
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Synthesis and antitumor activity of ring A modified 11-keto-β-boswellic acid derivatives.
Csuk R, Niesen-Barthel A, Schäfer R, Barthel A, Al-Harrasi A

Eur J Med Chem. 2015 Mar;92():700-11.
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Retraction notice to "Acetyl-11-β-boswellic acid (AKBA)inhibits human gastric carcinoma growth through modulation of the Wnt/β-canetin signalin pathway" Biochimica et Biophysica Acta [1830 (6) 3604-3615].

Biochim Biophys Acta. 2015 Jan;1850(1):254.
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Retraction notice to "Acetyl-11-keto-beta-boswellic acid (AKBA) prevents human colonic adenocarcinoma growth through modulation of multiple signaling pathways" Biochimica et Biophysica Acta [1830 (10) 4907-4916].

Biochim Biophys Acta. 2015 Jan;1850(1):253.
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The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA145 are potentiated by autophagy inhibitors.
Pathania AS, Wani ZA, Guru SK, Kumar S, Bhushan S, Korkaya H, Seals DF, Kumar A, Mondhe DM, Ahmed Z, Chandan BK, Malik F

Mol Cancer. 2015 Jan;14():6.
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An α-acetoxy-tirucallic acid isomer inhibits Akt/mTOR signaling and induces oxidative stress in prostate cancer cells.
El Gaafary M, Büchele B, Syrovets T, Agnolet S, Schneider B, Schmidt CQ, Simmet T

J Pharmacol Exp Ther. 2015 Jan;352(1):33-42.
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Effect of boswellia thurifera gum methanol extract on cytotoxicity and p53 gene expression in human breast cancer cell line.
Yazdanpanahi N, Behbahani M, Yektaeian A

Iran J Pharm Res. 2014;13(2):719-24.
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Caspase mediated synergistic effect of Boswellia serrata extract in combination with doxorubicin against human hepatocellular carcinoma.
Khan MA, Singh M, Khan MS, Najmi AK, Ahmad S

Biomed Res Int. 2014;2014():294143.
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Design, synthesis and biological evaluation of β-boswellic acid based HDAC inhibitors as inducers of cancer cell death.
Sharma S, Ahmad M, Bhat JA, Kumar A, Kumar M, Zargar MA, Hamid A, Shah BA

Bioorg Med Chem Lett. 2014 Oct;24(19):4729-4734.
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Differential effects of selective frankincense (Ru Xiang) essential oil versus non-selective sandalwood (Tan Xiang) essential oil on cultured bladder cancer cells: a microarray and bioinformatics study.
Dozmorov MG, Yang Q, Wu W, Wren J, Suhail MM, Woolley CL, Young DG, Fung KM, Lin HK

Chin Med. 2014;9():18.
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Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells.
Thummuri D, Jeengar MK, Shrivastava S, Areti A, Yerra VG, Yamjala S, Komirishetty P, Naidu VG, Kumar A, Sistla R

Environ Toxicol Pharmacol. 2014 Jul;38(1):58-70.
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Ultrastructural and hormonal changes in rat cauda epididymal spermatozoa induced by Boswellia papyrifera and Boswellia carterii.
Ahmed M, Ali D, Harrath AH, Hussain T, Al-Daghri N, Alokail MS, Aladakatti RH, Ghodesawar MA

C R Biol. 2014 Apr;337(4):250-7.
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The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice.
Wang R, Wang Y, Gao Z, Qu X

Drug Discov Ther. 2014 Feb;8(1):25-32.
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Major constituents of Boswellia carteri resin exhibit cyclooxygenase enzyme inhibition and antiproliferative activity.
Ali SI, Zhang CR, Mohamed AA, El-Baz FK, Hegazy AK, Kord MA, Nair MG

Nat Prod Commun. 2013 Oct;8(10):1365-6.
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Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059.
Pathania AS, Joshi A, Kumar S, Guru SK, Bhushan S, Sharma PR, Bhat WW, Saxena AK, Singh J, Shah BA, Andotra SS, Taneja SC, Malik FA, Kumar A

Apoptosis. 2013 Dec;18(12):1561-73.
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Acetyl-11-keto-beta-boswellic acid (AKBA) prevents human colonic adenocarcinoma growth through modulation of multiple signaling pathways.
Yuan Y, Cui SX, Wang Y, Ke HN, Wang RQ, Lou HX, Gao ZH, Qu XJ

Biochim Biophys Acta. 2013 Oct;1830(10):4907-16.
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Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105.
Khan MK, Ansari IA, Khan MS

Pharmacogn Mag. 2013 Jan;9(33):51-7.
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Boswellic acid and its inhibitory effect on tumor growth in systemic malignancies: an emerging concept in oncology.
Kapoor S

Future Oncol. 2013 May;9(5):627-8.
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Acetyl-11-keto-β-boswellic acid (AKBA) inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway.
Zhang YS, Xie JZ, Zhong JL, Li YY, Wang RQ, Qin YZ, Lou HX, Gao ZH, Qu XJ

Biochim Biophys Acta. 2013 Jun;1830(6):3604-15.
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Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model.
Ni X, Suhail MM, Yang Q, Cao A, Fung KM, Postier RG, Woolley C, Young G, Zhang J, Lin HK

BMC Complement Altern Med. 2012 Dec;12():253.
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Enhanced anticancer potential of encapsulated solid lipid nanoparticles of TPD: a novel triterpenediol from Boswellia serrata.
Bhushan S, Kakkar V, Pal HC, Guru SK, Kumar A, Mondhe DM, Sharma PR, Taneja SC, Kaur IP, Singh J, Saxena AK

Mol Pharm. 2013 Jan;10(1):225-35.
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A novel semisynthetic inhibitor of the FRB domain of mammalian target of rapamycin blocks proliferation and triggers apoptosis in chemoresistant prostate cancer cells.
Morad SA, Schmid M, Büchele B, Siehl HU, El Gafaary M, Lunov O, Syrovets T, Simmet T

Mol Pharmacol. 2013 Feb;83(2):531-41.
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NF-κB down-regulation and PARP cleavage by novel 3-α-butyryloxy-β-boswellic acid results in cancer cell specific apoptosis and in vivo tumor regression.
Qurishi Y, Hamid A, Sharma PR, Wani ZA, Mondhe DM, Singh SK, Zargar MA, Andotra SS, Shah BA, Taneja SC, Saxena AK

Anticancer Agents Med Chem. 2013 Jun;13(5):777-90.
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Chemoprevention of intestinal adenomatous polyposis by acetyl-11-keto-beta-boswellic acid in APC(Min/+) mice.
Liu HP, Gao ZH, Cui SX, Wang Y, Li BY, Lou HX, Qu XJ

Int J Cancer. 2013 Jun;132(11):2667-81.
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Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family.
Takahashi M, Sung B, Shen Y, Hur K, Link A, Boland CR, Aggarwal BB, Goel A

Carcinogenesis. 2012 Dec;33(12):2441-9.
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PARP cleavage and perturbance in mitochondrial membrane potential by 3-α-propionyloxy-β-boswellic acid results in cancer cell death and tumor regression in murine models.
Qurishi Y, Hamid A, Sharma PR, Wani ZA, Mondhe DM, Singh SK, Zargar MA, Andotra SS, Shah BA, Taneja SC, Saxena AK

Future Oncol. 2012 Jul;8(7):867-81.
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Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells.
Shen Y, Takahashi M, Byun HM, Link A, Sharma N, Balaguer F, Leung HC, Boland CR, Goel A

Cancer Biol Ther. 2012 May;13(7):542-52.
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[Chemopreventive effect of boswellic acid and curcumin on 7,12-dimethyl benzanthracene-induced hamster cheek pouch carcinogenesis].
Zhang XY, Chen XF, Sun Z, Miao CC, Ge LH, Tian ZC

Zhonghua Kou Qiang Yi Xue Za Zhi. 2011 Nov;46(11):678-83.
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Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells.
Suhail MM, Wu W, Cao A, Mondalek FG, Fung KM, Shih PT, Fang YT, Woolley C, Young G, Lin HK

BMC Complement Altern Med. 2011 Dec;11():129.
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Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.
Park B, Prasad S, Yadav V, Sung B, Aggarwal BB

PLoS One. 2011;6(10):e26943.
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Targeting Sp1 transcription factors in prostate cancer therapy.
Sankpal UT, Goodison S, Abdelrahim M, Basha R

Med Chem. 2011 Sep;7(5):518-25.
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Potentiation of the antitumor effect of 11-keto-β-boswellic acid by its 3-α-hexanoyloxy derivative.
Chashoo G, Singh SK, Mondhe DM, Sharma PR, Andotra SS, Shah BA, Taneja SC, Saxena AK

Eur J Pharmacol. 2011 Oct;668(3):390-400.
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A novel cyano derivative of 11-keto-β-boswellic acid causes apoptotic death by disrupting PI3K/AKT/Hsp-90 cascade, mitochondrial integrity, and other cell survival signaling events in HL-60 cells.
Khan S, Kaur R, Shah BA, Malik F, Kumar A, Bhushan S, Jain SK, Taneja SC, Singh J

Mol Carcinog. 2012 Sep;51(9):679-95.
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Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers.
Yadav VR, Prasad S, Sung B, Gelovani JG, Guha S, Krishnan S, Aggarwal BB

Int J Cancer. 2012 May;130(9):2176-84.
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Growth inhibitory, apoptotic and anti-inflammatory activities displayed by a novel modified triterpenoid, cyano enone of methyl boswellates.
Ravanan P, Singh SK, Rao GS, Kondaiah P

J Biosci. 2011 Jun;36(2):297-307.
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Antitumor properties of Boswellic acid against Ehrlich ascites cells bearing mouse.
Agrawal SS, Saraswati S, Mathur R, Pandey M

Food Chem Toxicol. 2011 Sep;49(9):1924-34.
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Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression.
Park B, Sung B, Yadav VR, Cho SG, Liu M, Aggarwal BB

Int J Cancer. 2011 Jul;129(1):23-33.
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A cyano analogue of boswellic acid induces crosstalk between p53/PUMA/Bax and telomerase that stages the human papillomavirus type 18 positive HeLa cells to apoptotic death.
Khan S, Chib R, Shah BA, Wani ZA, Dhar N, Mondhe DM, Lattoo S, Jain SK, Taneja SC, Singh J

Eur J Pharmacol. 2011 Jun;660(2-3):241-8.
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A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid.
Kaur R, Khan S, Chib R, Kaur T, Sharma PR, Singh J, Shah BA, Taneja SC

Eur J Med Chem. 2011 Apr;46(4):1356-66.
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[Effect of acetyl-11-keto-β-boswellic acid on proliferation, apoptosis and cell cycle of human acute myeloid leukemia cell line HL-60].
Yuan XY, Li YH, Qi ZH, Peng MY, Wan Z, Wang GP, Chen FP

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Dec;18(6):1440-4.
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[Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1].
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