10. Pharmakokinetik / Metabolismus

Publikationen

1. Metabolic Profile of 3-Acetyl-11-Keto-β-Boswellic Acid and 11-Keto-β-Boswellic Acid in Human Preparations In Vitro, Species Differences, and Bioactivity Variation.
Cui Y, Tian X, Ning J, Wang C, Yu Z, Wang Y, Huo X, Jin L, Deng S, Zhang B, Ma X

AAPS J. 2016 Jun;0(0):0.
PMID: 27329304 [PubMed - as supplied by publisher]

2. Nanoparticle formulation of 11-keto-β-boswellic acid (KBA): anti-inflammatory activity and in vivo pharmacokinetics.
Bairwa K, Jachak SM

Pharm Biol. 2016 Jun;0(0):1-8.
PMID: 27305832 [PubMed - as supplied by publisher]

3. Comparative studies of pharmacokinetics and anticoagulatory effect in rats after oral administration of Frankincense and its processed products.
Pan YN, Liang XX, Niu LY, Wang YN, Tong X, Hua HM, Zheng J, Meng DY, Liu XQ

J Ethnopharmacol. 2015 Aug;172(0):118-23.
PMID: 26117531 [PubMed - indexed for MEDLINE]

4. Boswellia carterii liquisolid systems with promoted anti-inflammatory activity.
Mostafa DM, Ammar NM, Abd El-Alim SH, Kassem AA, Hussein RA, Awad G, El-Awdan SA

Curr Drug Deliv. 2015;12(4):454-63.
PMID: 25895614 [PubMed - indexed for MEDLINE]

5. Acute and chronic toxicity, cytochrome p450 enzyme inhibition, and HERG channel blockade studies with a polyherbal, ayurvedic formulation for inflammation.
Dey D, Chaskar S, Athavale N, Chitre D

Biomed Res Int. 2015;2015(0):971982.
PMID: 25893199 [PubMed - indexed for MEDLINE]

6. Development and optimisation of 3-Acetyl-11-keto-β-boswellic acid loaded poly-lactic-co-glycolic acid-nanoparticles with enhanced oral bioavailability and in-vivo anti-inflammatory activity in rats.
Bairwa K, Jachak SM

J Pharm Pharmacol. 2015 Sep;67(9):1188-97.
PMID: 25851251 [PubMed - indexed for MEDLINE]

7. Prospects of boswellic acids as potential pharmaceutics.
Du Z, Liu Z, Ning Z, Liu Y, Song Z, Wang C, Lu A

Planta Med. 2015 Mar;81(4):259-71.
PMID: 25714728 [PubMed - indexed for MEDLINE]

8. Comparative pharmacokinetic study of two boswellic acids in normal and arthritic rat plasma after oral administration of Boswellia serrata extract or Huo Luo Xiao Ling Dan by LC-MS.
Wang H, Zhang C, Wu Y, Ai Y, Lee DY, Dai R

Biomed Chromatogr. 2014 Oct;28(10):1402-8.
PMID: 24806456 [PubMed - indexed for MEDLINE]

9. Transdermal microemulsions of Boswellia carterii Bird: formulation, characterization and in vivo evaluation of anti-inflammatory activity.
Mostafa DM, Ammar NM, Basha M, Hussein RA, El Awdan S, Awad G

Drug Deliv. 2015;22(6):748-56.
PMID: 24725029 [PubMed - indexed for MEDLINE]

10. Interference of boswellic acids with the ligand binding domain of the glucocorticoid receptor.
Scior T, Verhoff M, Gutierrez-Aztatzi I, Ammon HP, Laufer S, Werz O

J Chem Inf Model. 2014 Mar;54(3):978-86.
PMID: 24512031 [PubMed - indexed for MEDLINE]

11. Investigating permeability related hurdles in oral delivery of 11-keto-β-boswellic acid.
Bagul P, Khomane KS, Bansal AK

Int J Pharm. 2014 Apr;464(1-2):104-10.
PMID: 24463070 [PubMed - indexed for MEDLINE]

12. Microbial transformation of acetyl-11-keto-boswellic acid by Cunninghamella elegans.
Xin XL, Huo H, Chen L, Li J, Sun JH, Zheng PW, Sun Y, Wu ZM, Xiong YH

J Asian Nat Prod Res. 2013 Nov;15(11):1173-8.
PMID: 24168329 [PubMed - indexed for MEDLINE]

13. Biotransformation of 11-keto-β-boswellic acid by Cunninghamella blakesleana.
Wang Y, Sun Y, Wang C, Huo X, Liu P, Wang C, Zhang B, Zhan L, Zhang H, Deng S, Zhao Y, Ma X

Phytochemistry. 2013 Dec;96(0):330-6.
PMID: 23962801 [PubMed - indexed for MEDLINE]

14. A new cytochrome P450 system from Bacillus megaterium DSM319 for the hydroxylation of 11-keto-β-boswellic acid (KBA).
Brill E, Hannemann F, Zapp J, Brüning G, Jauch J, Bernhardt R

Appl Microbiol Biotechnol. 2014 Feb;98(4):1701-17.
PMID: 23797329 [PubMed - indexed for MEDLINE]

15. Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugate.
Suneela D, Dipmala P

Bioorg Med Chem Lett. 2012 Dec;22(24):7582-7.
PMID: 23107483 [PubMed - indexed for MEDLINE]

16. In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins.
Gerbeth K, Hüsch J, Fricker G, Werz O, Schubert-Zsilavecz M, Abdel-Tawab M

Fitoterapia. 2013 Jan;84(0):99-106.
PMID: 23103296 [PubMed - indexed for MEDLINE]

17. Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.
Hüsch J, Bohnet J, Fricker G, Skarke C, Artaria C, Appendino G, Schubert-Zsilavecz M, Abdel-Tawab M

Fitoterapia. 2013 Jan;84(0):89-98.
PMID: 23092618 [PubMed - indexed for MEDLINE]

18. Effect of phospholipid-based formulations of Boswellia serrata extract on the solubility, permeability, and absorption of the individual boswellic acid constituents present.
Hüsch J, Gerbeth K, Fricker G, Setzer C, Zirkel J, Rebmann H, Schubert-Zsilavecz M, Abdel-Tawab M

J Nat Prod. 2012 Oct;75(10):1675-82.
PMID: 23013292 [PubMed - indexed for MEDLINE]

19. [Does a positive finding of tetrahydrocannabinol in the blood result from ingestion of Indian frankincense (Boswellia serrata)?].
Skopp G, Schmitt G

Arch Kriminol. 2012 May-Jun;229(5-6):154-62.
PMID: 22834359 [PubMed - indexed for MEDLINE]

20. Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice.
Yin MC, Lin MC, Mong MC, Lin CY

J Agric Food Chem. 2012 Aug;60(31):7697-701.
PMID: 22816768 [PubMed - indexed for MEDLINE]

21. Hydroxylation of the triterpenoid dipterocarpol with CYP106A2 from Bacillus megaterium.
Schmitz D, Zapp J, Bernhardt R

FEBS J. 2012 May;279(9):1663-74.
PMID: 22269065 [PubMed - indexed for MEDLINE]

22. Increased bioavailability of 11-keto-β-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: modeling and simulation considerations for evaluating drug exposures.
Skarke C, Kuczka K, Tausch L, Werz O, Rossmanith T, Barrett JS, Harder S, Holtmeier W, Schwarz JA

J Clin Pharmacol. 2012 Oct;52(10):1592-600.
PMID: 22167571 [PubMed - indexed for MEDLINE]

23. Determination of major boswellic acids in plasma by high-pressure liquid chromatography/mass spectrometry.
Gerbeth K, Meins J, Kirste S, Momm F, Schubert-Zsilavecz M, Abdel-Tawab M

J Pharm Biomed Anal. 2011 Dec;56(5):998-1005.
PMID: 21855244 [PubMed - indexed for MEDLINE]

24. A new Bacillus megaterium whole-cell catalyst for the hydroxylation of the pentacyclic triterpene 11-keto-β-boswellic acid (KBA) based on a recombinant cytochrome P450 system.
Bleif S, Hannemann F, Zapp J, Hartmann D, Jauch J, Bernhardt R

Appl Microbiol Biotechnol. 2012 Feb;93(3):1135-46.
PMID: 21779845 [PubMed - indexed for MEDLINE]

25. Complexation with phosphatidyl choline as a strategy for absorption enhancement of boswellic acid.
Sharma A, Gupta NK, Dixit VK

Drug Deliv. 2010 Nov;17(8):587-95.
PMID: 20624027 [PubMed - indexed for MEDLINE]

26. 3-Acetyl-11-keto-beta-boswellic acid loaded-polymeric nanomicelles for topical anti-inflammatory and anti-arthritic activity.
Goel A, Ahmad FJ, Singh RM, Singh GN

J Pharm Pharmacol. 2010 Feb;62(2):273-8.
PMID: 20487208 [PubMed - indexed for MEDLINE]

27. Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2.
Krüger P, Kanzer J, Hummel J, Fricker G, Schubert-Zsilavecz M, Abdel-Tawab M

Eur J Pharm Sci. 2009 Feb;36(2-3):275-84.
PMID: 19010411 [PubMed - indexed for MEDLINE]

28. Metabolism of boswellic acids in vitro and in vivo.
Krüger P, Daneshfar R, Eckert GP, Klein J, Volmer DA, Bahr U, Müller WE, Karas M, Schubert-Zsilavecz M, Abdel-Tawab M

Drug Metab Dispos. 2008 Jun;36(6):1135-42.
PMID: 18356270 [PubMed - indexed for MEDLINE]

29. Compression coated systems for colonic delivery of 5-fluorouracil.
Sinha VR, Singh A, Singh S, Bhinge JR

J Pharm Pharmacol. 2007 Mar;59(3):359-65.
PMID: 17331338 [PubMed - indexed for MEDLINE]

30. Estimation of boswellic acids from market formulations of Boswellia serrata extract and 11-keto beta-boswellic acid in human plasma by high-performance thin-layer chromatography.
Shah SA, Rathod IS, Suhagia BN, Patel DA, Parmar VK, Shah BK, Vaishnavi VM

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Apr;848(2):232-8.
PMID: 17101304 [PubMed - indexed for MEDLINE]

31. Modulation of Pgp function by boswellic acids.
Weber CC, Reising K, Müller WE, Schubert-Zsilavecz M, Abdel-Tawab M

Planta Med. 2006 May;72(6):507-13.
PMID: 16773534 [PubMed - indexed for MEDLINE]

32. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction.
Frank A, Unger M

J Chromatogr A. 2006 Apr;1112(1-2):255-62.
PMID: 16364338 [PubMed - indexed for MEDLINE]

33. High-performance liquid chromatographic determination of acetyl-11-keto-alpha-boswellic acid, a novel pentacyclic triterpenoid, in plasma using a fluorinated stationary phase and photodiode array detection: application in pharmacokinetic studies.
Büchele B, Zugmaier W, Genze F, Simmet T

J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Dec;829(1-2):144-8.
PMID: 16266833 [PubMed - indexed for MEDLINE]

34. Determination of boswellic acids in brain and plasma by high-performance liquid chromatography/tandem mass spectrometry.
Reising K, Meins J, Bastian B, Eckert G, Mueller WE, Schubert-Zsilavecz M, Abdel-Tawab M

Anal Chem. 2005 Oct;77(20):6640-5.
PMID: 16223251 [PubMed - indexed for MEDLINE]

35. Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers.
Sterk V, Büchele B, Simmet T

Planta Med. 2004 Dec;70(12):1155-60.
PMID: 15643550 [PubMed - indexed for MEDLINE]

36. Pharmacokinetic study of 11-Keto beta-Boswellic acid.
Sharma S, Thawani V, Hingorani L, Shrivastava M, Bhate VR, Khiyani R

Phytomedicine. 2004 Feb;11(2-3):255-60.
PMID: 15070181 [PubMed - indexed for MEDLINE]

37. Analysis of 12 different pentacyclic triterpenic acids from frankincense in human plasma by high-performance liquid chromatography and photodiode array detection.
Büchele B, Simmet T

J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Oct;795(2):355-62.
PMID: 14522040 [PubMed - indexed for MEDLINE]

38. Determination of 11-keto-boswellic acid in human plasma.
Kaunzinger A, Baumeister A, Cuda K, Häring N, Schug B, Blume HH, Raddatz K, Fischer G, Schubert-Zsilavecz M

J Pharm Biomed Anal. 2002 May;28(3-4):729-39.
PMID: 12008153 [PubMed - indexed for MEDLINE]

39. Development of a high-performance liquid chromatographic method for the determination of 11-keto-beta-boswellic acid in human plasma.
Tawab MA, Kaunzinger A, Bahr U, Karas M, Wurglics M, Schubert-Zsilavecz M

J Chromatogr B Biomed Sci Appl. 2001 Sep;761(2):221-7.
PMID: 11587352 [PubMed - indexed for MEDLINE]