10. Pharmakokinetik / Metabolismus



Adsorption kinetics, isotherm, and thermodynamics studies of acetyl-11-keto-β-boswellic acids (AKBA) from Boswellia serrata extract using macroporous resin.

Prep Biochem Biotechnol. 2017 Sep;47(8):804-812.
PMID: 28662360 [PubMed - indexed for MEDLINE]


New water soluble glycosides of 11-keto-β-boswellic acid: A paradigm.

Nat Prod Res. 2018 Jan;32(2):154-161.
PMID: 28627258 [PubMed - indexed for MEDLINE]


P-gp modulatory acetyl-11-keto-β-boswellic acid based nanoemulsified carrier system for augmented oral chemotherapy of docetaxel.

Colloids Surf B Biointerfaces. 2017 Jul;155():276-286.
PMID: 28437753 [PubMed - indexed for MEDLINE]


A single-dose, randomized, cross-over, two-way, open-label study for comparing the absorption of boswellic acids and its lecithin formulation.

Phytomedicine. 2016 Nov;23(12):1375-1382.
PMID: 27765357 [PubMed - indexed for MEDLINE]


Metabolic Profile of 3-Acetyl-11-Keto-β-Boswellic Acid and 11-Keto-β-Boswellic Acid in Human Preparations In Vitro, Species Differences, and Bioactivity Variation.

AAPS J. 2016 09;18(5):1273-88.
PMID: 27329304 [PubMed - indexed for MEDLINE]


Nanoparticle formulation of 11-keto-β-boswellic acid (KBA): anti-inflammatory activity and in vivo pharmacokinetics.

Pharm Biol. 2016 Dec;54(12):2909-2916.
PMID: 27305832 [PubMed - as supplied by publisher]


Comparative studies of pharmacokinetics and anticoagulatory effect in rats after oral administration of Frankincense and its processed products.

J Ethnopharmacol. 2015 Aug;172():118-23.
PMID: 26117531 [PubMed - indexed for MEDLINE]


Boswellia carterii liquisolid systems with promoted anti-inflammatory activity.

Curr Drug Deliv. 2015;12(4):454-63.
PMID: 25895614 [PubMed - indexed for MEDLINE]


Acute and chronic toxicity, cytochrome p450 enzyme inhibition, and HERG channel blockade studies with a polyherbal, ayurvedic formulation for inflammation.

Biomed Res Int. 2015;2015():971982.
PMID: 25893199 [PubMed - indexed for MEDLINE]


Development and optimisation of 3-Acetyl-11-keto-β-boswellic acid loaded poly-lactic-co-glycolic acid-nanoparticles with enhanced oral bioavailability and in-vivo anti-inflammatory activity in rats.

J Pharm Pharmacol. 2015 Sep;67(9):1188-97.
PMID: 25851251 [PubMed - indexed for MEDLINE]


Prospects of boswellic acids as potential pharmaceutics.

Planta Med. 2015 Mar;81(4):259-71.
PMID: 25714728 [PubMed - indexed for MEDLINE]


Comparative pharmacokinetic study of two boswellic acids in normal and arthritic rat plasma after oral administration of Boswellia serrata extract or Huo Luo Xiao Ling Dan by LC-MS.

Biomed Chromatogr. 2014 Oct;28(10):1402-8.
PMID: 24806456 [PubMed - indexed for MEDLINE]


Transdermal microemulsions of Boswellia carterii Bird: formulation, characterization and in vivo evaluation of anti-inflammatory activity.

Drug Deliv. 2015;22(6):748-56.
PMID: 24725029 [PubMed - indexed for MEDLINE]


Interference of boswellic acids with the ligand binding domain of the glucocorticoid receptor.

J Chem Inf Model. 2014 Mar;54(3):978-86.
PMID: 24512031 [PubMed - indexed for MEDLINE]


Investigating permeability related hurdles in oral delivery of 11-keto-β-boswellic acid.

Int J Pharm. 2014 Apr;464(1-2):104-10.
PMID: 24463070 [PubMed - indexed for MEDLINE]


Microbial transformation of acetyl-11-keto-boswellic acid by Cunninghamella elegans.

J Asian Nat Prod Res. 2013 Nov;15(11):1173-8.
PMID: 24168329 [PubMed - indexed for MEDLINE]


Biotransformation of 11-keto-β-boswellic acid by Cunninghamella blakesleana.

Phytochemistry. 2013 Dec;96():330-6.
PMID: 23962801 [PubMed - indexed for MEDLINE]


A new cytochrome P450 system from Bacillus megaterium DSM319 for the hydroxylation of 11-keto-β-boswellic acid (KBA).

Appl Microbiol Biotechnol. 2014 Feb;98(4):1701-17.
PMID: 23797329 [PubMed - indexed for MEDLINE]


Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugate.

Bioorg Med Chem Lett. 2012 Dec;22(24):7582-7.
PMID: 23107483 [PubMed - indexed for MEDLINE]


In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins.

Fitoterapia. 2013 Jan;84():99-106.
PMID: 23103296 [PubMed - indexed for MEDLINE]


Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.

Fitoterapia. 2013 Jan;84():89-98.
PMID: 23092618 [PubMed - indexed for MEDLINE]


Effect of phospholipid-based formulations of Boswellia serrata extract on the solubility, permeability, and absorption of the individual boswellic acid constituents present.

J Nat Prod. 2012 Oct;75(10):1675-82.
PMID: 23013292 [PubMed - indexed for MEDLINE]


[Does a positive finding of tetrahydrocannabinol in the blood result from ingestion of Indian frankincense (Boswellia serrata)?].

Arch Kriminol. 2012 May-Jun;229(5-6):154-62.
PMID: 22834359 [PubMed - indexed for MEDLINE]


Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice.

J Agric Food Chem. 2012 Aug;60(31):7697-701.
PMID: 22816768 [PubMed - indexed for MEDLINE]


Hydroxylation of the triterpenoid dipterocarpol with CYP106A2 from Bacillus megaterium.

FEBS J. 2012 May;279(9):1663-74.
PMID: 22269065 [PubMed - indexed for MEDLINE]


Increased bioavailability of 11-keto-β-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: modeling and simulation considerations for evaluating drug exposures.

J Clin Pharmacol. 2012 Oct;52(10):1592-600.
PMID: 22167571 [PubMed - indexed for MEDLINE]


Determination of major boswellic acids in plasma by high-pressure liquid chromatography/mass spectrometry.

J Pharm Biomed Anal. 2011 Dec;56(5):998-1005.
PMID: 21855244 [PubMed - indexed for MEDLINE]


A new Bacillus megaterium whole-cell catalyst for the hydroxylation of the pentacyclic triterpene 11-keto-β-boswellic acid (KBA) based on a recombinant cytochrome P450 system.

Appl Microbiol Biotechnol. 2012 Feb;93(3):1135-46.
PMID: 21779845 [PubMed - indexed for MEDLINE]


Complexation with phosphatidyl choline as a strategy for absorption enhancement of boswellic acid.

Drug Deliv. 2010 Nov;17(8):587-95.
PMID: 20624027 [PubMed - indexed for MEDLINE]


3-Acetyl-11-keto-beta-boswellic acid loaded-polymeric nanomicelles for topical anti-inflammatory and anti-arthritic activity.

J Pharm Pharmacol. 2010 Feb;62(2):273-8.
PMID: 20487208 [PubMed - indexed for MEDLINE]


Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2.

Eur J Pharm Sci. 2009 Feb;36(2-3):275-84.
PMID: 19010411 [PubMed - indexed for MEDLINE]


Metabolism of boswellic acids in vitro and in vivo.

Drug Metab Dispos. 2008 Jun;36(6):1135-42.
PMID: 18356270 [PubMed - indexed for MEDLINE]


Compression coated systems for colonic delivery of 5-fluorouracil.

J Pharm Pharmacol. 2007 Mar;59(3):359-65.
PMID: 17331338 [PubMed - indexed for MEDLINE]


Estimation of boswellic acids from market formulations of Boswellia serrata extract and 11-keto beta-boswellic acid in human plasma by high-performance thin-layer chromatography.

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Apr;848(2):232-8.
PMID: 17101304 [PubMed - indexed for MEDLINE]


Modulation of Pgp function by boswellic acids.

Planta Med. 2006 May;72(6):507-13.
PMID: 16773534 [PubMed - indexed for MEDLINE]


Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction.

J Chromatogr A. 2006 Apr;1112(1-2):255-62.
PMID: 16364338 [PubMed - indexed for MEDLINE]


High-performance liquid chromatographic determination of acetyl-11-keto-alpha-boswellic acid, a novel pentacyclic triterpenoid, in plasma using a fluorinated stationary phase and photodiode array detection: application in pharmacokinetic studies.

J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Dec;829(1-2):144-8.
PMID: 16266833 [PubMed - indexed for MEDLINE]


Determination of boswellic acids in brain and plasma by high-performance liquid chromatography/tandem mass spectrometry.

Anal Chem. 2005 Oct;77(20):6640-5.
PMID: 16223251 [PubMed - indexed for MEDLINE]


Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers.

Planta Med. 2004 Dec;70(12):1155-60.
PMID: 15643550 [PubMed - indexed for MEDLINE]


Pharmacokinetic study of 11-Keto beta-Boswellic acid.

Phytomedicine. 2004 Feb;11(2-3):255-60.
PMID: 15070181 [PubMed - indexed for MEDLINE]


Analysis of 12 different pentacyclic triterpenic acids from frankincense in human plasma by high-performance liquid chromatography and photodiode array detection.

J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Oct;795(2):355-62.
PMID: 14522040 [PubMed - indexed for MEDLINE]


Determination of 11-keto-boswellic acid in human plasma.

J Pharm Biomed Anal. 2002 May;28(3-4):729-39.
PMID: 12008153 [PubMed - indexed for MEDLINE]


Development of a high-performance liquid chromatographic method for the determination of 11-keto-beta-boswellic acid in human plasma.

J Chromatogr B Biomed Sci Appl. 2001 Sep;761(2):221-7.
PMID: 11587352 [PubMed - indexed for MEDLINE]