8.2.1 Nervensystem



Autophagy machinery plays an essential role in traumatic brain injury-induced apoptosis and its related behavioral abnormalities in mice: focus on Sacra gum resin.
Interdonato L, Marino Y, Impellizzeri D, D'Amico R, Siracusa R, Fusco R, Cammilleri G, Pantano L, Modafferi S, Abdelhameed AS, Fritsch T, Rashan LJ, Cuzzocrea S, Calabrese V, Cordaro M, Di Paola R

Front Physiol. 2023;14():1320960.
PMID: 38250661 [PubMed - as supplied by publisher]


Acetyl-11-Keto-β-Boswellic Acid Accelerates the Repair of Spinal Cord Injury in Rats by Resisting Neuronal Pyroptosis with Nrf2.
Wang Y, Xiong Z, Zhang Q, Liu M, Zhang J, Qi X, Jiang X, Yu W

Int J Mol Sci. 2023 Dec;25(1):.
PMID: 38203528 [PubMed - indexed for MEDLINE]


Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat.
Aljarari RM

Braz J Biol. 2023;83():e272466.
PMID: 37851769 [PubMed - indexed for MEDLINE]


The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases.
Darwish SF, Elbadry AMM, Elbokhomy AS, Salama GA, Salama RM

Front Aging. 2023;4():1231706.
PMID: 37744008 [PubMed - as supplied by publisher]


Synergistic effects of Boswellia serrata and Acmella oleracea extract combination for treating neuropathic pain in a preclinical model of spared nerve injury.
Boccella S, Mattia C, Perrone M, Morace AM, Karabacak E, Guida F, Maione S, Luongo L

Phytother Res. 2024 Apr;38(4):1731-1734.
PMID: 37661796 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-beta boswellic acid(AKBA) modulates CSTC-pathway by activating SIRT-1/Nrf2-HO-1 signalling in experimental rat model of obsessive-compulsive disorder: Evidenced by CSF, blood plasma and histopathological alterations.
Sethi P, Mehan S, Khan Z, Chhabra S

Neurotoxicology. 2023 Sep;98():61-85.
PMID: 37549874 [PubMed - indexed for MEDLINE]


Acetyl-11-Keto-Beta-Boswellic Acid Activates the Nrf2/HO-1 Signaling Pathway in Schwann Cells to Reduce Oxidative Stress and Promote Sciatic Nerve Injury Repair.
Zhou C, Wang Y, Zhang Q, Zhou G, Ma X, Jiang X, Yu W

Planta Med. 2023 Dec;89(15):1468-1482.
PMID: 37541437 [PubMed - indexed for MEDLINE]


Modulation of Kv7 Channel Currents by Echinocystic Acid.
Geng D, Li Y, Zheng R, Wang R, Yang B, Zhang H, Zhang Y, Zhang F

Mol Pharmacol. 2023 Aug;104(2):42-50.
PMID: 37280100 [PubMed - indexed for MEDLINE]


Novel synergistic mechanism of 11-keto-β-boswellic acid and Z-Guggulsterone on ischemic stroke revealed by single-cell transcriptomics.
Liu T, Bai M, Liu M, Li T, Liao Y, Zhao C, Yao M, Wang J, Wen A, Ding Y

Pharmacol Res. 2023 Jul;193():106803.
PMID: 37230158 [PubMed - indexed for MEDLINE]


Molecular Targets Underlying the Neuroprotective Effects of Boswellic Acid: A Systematic Review.
Khaafi F, Javadi B

Mini Rev Med Chem. 2023;23(19):1912-1925.
PMID: 36998129 [PubMed - indexed for MEDLINE]


Protective Mechanisms of 3-Acetyl-11-keto-β-Boswellic Acid and Piperine in Fluid Percussion Rat Model of Traumatic Brain Injury Targeting Nrf2 and NFkB Signaling.
Kundu S, Singh S

Neurotox Res. 2023 Feb;41(1):57-84.
PMID: 36576717 [PubMed - indexed for MEDLINE]


AKBA Promotes Axonal Regeneration via RhoA/Rictor to Repair Damaged Sciatic Nerve.
Wang Y, Xiong Z, Zhou C, Zhang Q, Liu S, Dong S, Jiang X, Yu W

Int J Mol Sci. 2022 Dec;23(24):.
PMID: 36555556 [PubMed - indexed for MEDLINE]


Synthesis and antidepressant-like effects of new 5-epi-incensole and 5-epi- incensole acetate in chronic unpredictable mild stress model of depression; behavioural and biochemical correlates.
Avula SK, Khan A, Halim SA, Rehman NU, Karim N, Khan I, Csuk R, Das B, Al-Harrasi A

Biomed Pharmacother. 2022 Dec;156():113960.
PMID: 36411640 [PubMed - indexed for MEDLINE]


Boswellic acids as promising agents for the management of brain diseases.
Rajabian A, Farzanehfar M, Hosseini H, Arab FL, Nikkhah A

Life Sci. 2023 Jan;312():121196.
PMID: 36400202 [PubMed - indexed for MEDLINE]


Frankincense-Myrrh treatment alleviates neuropathic pain via the inhibition of neuroglia activation mediated by the TLR4/MyD88 pathway and TRPV1 signaling.
Liao Y, Guo C, Wen A, Bai M, Ran Z, Hu J, Wang J, Yang J, Ding Y

Phytomedicine. 2023 Jan;108():154540.
PMID: 36379093 [PubMed - indexed for MEDLINE]


Beta-Boswellic Acid Reverses 3-Nitropropionic Acid-Induced Molecular, Mitochondrial, and Histopathological Defects in Experimental Rat Model of Huntington's Disease.
Albekairi TH, Kamra A, Bhardwaj S, Mehan S, Giri A, Suri M, Alshammari A, Alharbi M, Alasmari AF, Narula AS, Kalfin R

Biomedicines. 2022 Nov;10(11):.
PMID: 36359390 [PubMed - as supplied by publisher]


Neuropharmacological Effects of Terpenoids on Preclinical Animal Models of Psychiatric Disorders: A Review.
Mony TJ, Elahi F, Choi JW, Park SJ

Antioxidants (Basel). 2022 Sep;11(9):.
PMID: 36139909 [PubMed - as supplied by publisher]


Inhibition Of Tau Protein Aggregation By a Chaperone-like β-Boswellic Acid Conjugated To Gold Nanoparticles.
Gharb M, Nouralishahi A, Riazi A, Riazi G

ACS Omega. 2022 Aug;7(34):30347-30358.
PMID: 36061732 [PubMed - as supplied by publisher]


Nrf2/HO-1 Signaling Stimulation through Acetyl-11-Keto-Beta-Boswellic Acid (AKBA) Provides Neuroprotection in Ethidium Bromide-Induced Experimental Model of Multiple Sclerosis.
Upadhayay S, Mehan S, Prajapati A, Sethi P, Suri M, Zawawi A, Almashjary MN, Tabrez S

Genes (Basel). 2022 Jul;13(8):.
PMID: 35893061 [PubMed - indexed for MEDLINE]


Methanolic Extract of Boswellia serrata Gum Protects the Nigral Dopaminergic Neurons from Rotenone-Induced Neurotoxicity.
Shadfar S, Khanal S, Bohara G, Kim G, Sadigh-Eteghad S, Ghavami S, Choi H, Choi DY

Mol Neurobiol. 2022 Sep;59(9):5874-5890.
PMID: 35804280 [PubMed - indexed for MEDLINE]


Author Correction: Neuroprotection by acetyl-11-keto-β-boswellic acid, in ischemic brain injury involves the Nrf2/HO-1 defense pathway.
Ding Y, Chen M, Wang M, Wang M, Zhang T, Park J, Zhu Y, Guo C, Jia Y, Li Y, Wen A

Sci Rep. 2022 Jul;12(1):11547.
PMID: 35798757 [PubMed - as supplied by publisher]


Incensole derivatives from frankincense: Isolation, enhancement, synthetic modification, and a plausible mechanism of their anti-depression activity.
Ur Rehman N, Al-Shidhani S, Karim N, Khan A, Khan I, Ahsan Halim S, Khan Sadozai S, Kumar Avula S, Csuk R, Al-Harrasi A

Bioorg Chem. 2022 Sep;126():105900.
PMID: 35671644 [PubMed - indexed for MEDLINE]


Boswellic acids ameliorate neurodegeneration induced by AlCl: the implication of Wnt/β-catenin pathway.
Mohamed EA, Ahmed HI, Zaky HS, Badr AM

Environ Sci Pollut Res Int. 2022 Oct;29(50):76135-76143.
PMID: 35668264 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-beta-boswellic acid promotes sciatic nerve repair after injury: molecular mechanism.
Wang Y, Xiong ZL, Ma XL, Zhou C, Huo MH, Jiang XW, Yu WH

Neural Regen Res. 2022 Dec;17(12):2778-2784.
PMID: 35662229 [PubMed - as supplied by publisher]


Beta-Boswellic Acid Protects Against Cerebral Ischemia/Reperfusion Injury via the Protein Kinase C Epsilon/Nuclear Factor Erythroid 2-like 2/Heme Oxygenase-1 Pathway.
Wang M, Yu J, Yang Q, Guo C, Zhang W, Li W, Weng Y, Ding Y, Wang J

Mol Neurobiol. 2022 Jul;59(7):4242-4256.
PMID: 35505050 [PubMed - indexed for MEDLINE]


The Biological Activity of 3-O-Acetyl-11-keto-β-Boswellic Acid in Nervous System Diseases.
Gong Y, Jiang X, Yang S, Huang Y, Hong J, Ma Y, Fang X, Fang Y, Wu J

Neuromolecular Med. 2022 Dec;24(4):374-384.
PMID: 35303275 [PubMed - indexed for MEDLINE]


Molecular evidences on anti-inflammatory, anticancer, and memory-boosting effects of frankincense.
Khajehdehi M, Khalaj-Kondori M, Baradaran B

Phytother Res. 2022 Mar;36(3):1194-1215.
PMID: 35142408 [PubMed - indexed for MEDLINE]


Review of the Chemical Composition, Pharmacological Effects, Pharmacokinetics, and Quality Control of .
Huang K, Chen Y, Liang K, Xu X, Jiang J, Liu M, Zhou F

Evid Based Complement Alternat Med. 2022;2022():6627104.
PMID: 35069765 [PubMed - as supplied by publisher]


Mechanistic role of boswellic acids in Alzheimer's disease: Emphasis on anti-inflammatory properties.
Siddiqui A, Shah Z, Jahan RN, Othman I, Kumari Y

Biomed Pharmacother. 2021 Dec;144():112250.
PMID: 34607104 [PubMed - indexed for MEDLINE]


3-O-Acetyl-11-keto-β-boswellic acid ameliorates chronic unpredictable mild stress induced HPA axis dysregulation in relation with glutamate/GABA aberration in depressive rats.
Gunasekaran V, Augustine A, Avarachan J, Khayum A, Ramasamy A

Clin Exp Pharmacol Physiol. 2021 Dec;48(12):1633-1641.
PMID: 34343356 [PubMed - indexed for MEDLINE]


An engineered microfluidic blood-brain barrier model to evaluate the anti-metastatic activity of β-boswellic acid.
Vakilian S, Alam K, Al-Kindi J, Jamshidi-Adegani F, Rehman NU, Tavakoli R, Al-Riyami K, Hasan A, Zadjali F, Csuk R, Al-Harrasi A, Al-Hashmi S

Biotechnol J. 2021 Oct;16(10):e2100044.
PMID: 34313388 [PubMed - indexed for MEDLINE]


Protection of Beta Boswellic Acid against Streptozotocin-induced Alzheimer's Model by Reduction of Tau Phosphorylation Level and Enhancement of Reelin Expression.
Shasaltaneh MD, Naghdi N, Ramezani S, Alizadeh L, Riazi GH

Planta Med. 2022 Apr;88(5):367-379.
PMID: 34116571 [PubMed - indexed for MEDLINE]


Nrf2/HO-1 Signaling Activator Acetyl-11-keto-beta Boswellic Acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-Induced Experimental Model of ALS.
Minj E, Upadhayay S, Mehan S

Neurochem Res. 2021 Nov;46(11):2867-2884.
PMID: 34075522 [PubMed - indexed for MEDLINE]


Sublingual AKBA Exerts Antidepressant Effects in the Aβ-Treated Mouse Model.
Morgese MG, Bove M, Francavilla M, Schiavone S, Dimonte S, Colia AL, Bevilacqua M, Trabace L, Tucci P

Biomolecules. 2021 May;11(5):.
PMID: 34063630 [PubMed - indexed for MEDLINE]


Boswellia serrata suppress fipronil-induced neuronal necrosis and neurobehavioral alterations via promoted inhibition of oxidative/inflammatory/apoptotic pathways.
Khafaga AF, El-Kazaz SE, Noreldin AE

Sci Total Environ. 2021 Sep;785():147384.
PMID: 33933775 [PubMed - indexed for MEDLINE]


Identification of Potential Antiseizure Agents in using Zebrafish and Mouse Epilepsy Models.
Brillatz T, Jacmin M, Queiroz EF, Marcourt L, Morin H, Shahbazi N, Boulens N, Riva A, Crawford AD, Allémann E, Wolfender JL

ACS Chem Neurosci. 2021 May;12(10):1791-1801.
PMID: 33926190 [PubMed - indexed for MEDLINE]


Alzheimer's disease improved through the activity of mitochondrial chain complexes and their gene expression in rats by boswellic acid.
Mohamed TM, Youssef MAM, Bakry AA, El-Keiy MM

Metab Brain Dis. 2021 Feb;36(2):255-264.
PMID: 33159653 [PubMed - indexed for MEDLINE]


The effects of the combination of Cyperus rotundus, Crocus sativus, Piper nigrum, and Boswellia serrata on learning and memory deficit and oxidative damage in brain tissue of hypothyroid rats.
Saeri S, Hadjzadeh MA, Hosseini M, Hosseinian S, Arab Z

J Food Biochem. 2020 Sep;44(9):e13391.
PMID: 32696531 [PubMed - indexed for MEDLINE]


The Effect of Beta-Boswellic Acid on the Expression of and Genes in the PC12 Cell Line.
Jebelli A, Khalaj-Kondori M, Rahmati-Yamchi M

Adv Pharm Bull. 2020 Jul;10(3):437-443.
PMID: 32665903 [PubMed - as supplied by publisher]


PCL/gelatin scaffolds and beta-boswellic acid synergistically increase the efficiency of CGR8 stem cells differentiation into dopaminergic neuron: A new paradigm of Parkinson's disease cell therapy.
Kheradmand H, Babaloo H, Vojgani Y, Mirzakhanlouei S, Bayat N

J Biomed Mater Res A. 2021 Apr;109(4):562-571.
PMID: 32588502 [PubMed - indexed for MEDLINE]


Ten undescribed cembrane-type diterpenoids from the gum resin of Boswellia sacra and their biological activities.
Wang JJ, Sun HR, Suo XY, Xue Wang , Sun H, Wang XL, Jiang JD, Ji TF

Phytochemistry. 2020 Sep;177():112425.
PMID: 32535347 [PubMed - indexed for MEDLINE]


Genus as a new candidate for neurodegenerative disorders.
Rajabian A, Sadeghnia H, Fanoudi S, Hosseini A

Iran J Basic Med Sci. 2020 Mar;23(3):277-286.
PMID: 32440312 [PubMed - as supplied by publisher]


Frankincense and myrrh and their bioactive compounds ameliorate the multiple myeloma through regulation of metabolome profiling and JAK/STAT signaling pathway based on U266 cells.
Gao R, Miao X, Sun C, Su S, Zhu Y, Qian D, Ouyang Z, Duan J

BMC Complement Med Ther. 2020 Mar;20(1):96.
PMID: 32293402 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid ameliorates cognitive deficits and reduces amyloid-β levels in APPswe/PS1dE9 mice through antioxidant and anti-inflammatory pathways.
Wei C, Fan J, Sun X, Yao J, Guo Y, Zhou B, Shang Y

Free Radic Biol Med. 2020 Apr;150():96-108.
PMID: 32109514 [PubMed - indexed for MEDLINE]


11-Keto-β-Boswellic Acid Attenuates Glutamate Release and Kainic Acid-Induced Excitotoxicity in the Rat Hippocampus.
Lu CW, Lin TY, Wang SJ

Planta Med. 2020 Apr;86(6):434-441.
PMID: 32097973 [PubMed - indexed for MEDLINE]


3--Acetyl-11-keto- -boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma.
Li W, Ren L, Zheng X, Liu J, Wang J, Ji T, Du G

Acta Pharm Sin B. 2020 Feb;10(2):301-312.
PMID: 32082975 [PubMed - as supplied by publisher]


Kinetic and thermodynamic study of beta-Boswellic acid interaction with Tau protein investigated by surface plasmon resonance and molecular modeling methods.
Haghaei H, Aref Hosseini SR, Soltani S, Fathi F, Mokhtari F, Karima S, Rashidi MR

Bioimpacts. 2020;10(1):17-25.
PMID: 31988853 [PubMed - as supplied by publisher]


3-Acetyl-11-keto-β-boswellic acid attenuated oxidative glutamate toxicity in neuron-like cell lines by apoptosis inhibition.
Rajabian A, Sadeghnia HR, Hosseini A, Mousavi SH, Boroushaki MT

J Cell Biochem. 2020 Feb;121(2):1778-1789.
PMID: 31642100 [PubMed - indexed for MEDLINE]


Loading AKBA on surface of silver nanoparticles to improve their sedative-hypnotic and anti-inflammatory efficacies.
Khan A, Al-Harrasi A, Rehman NU, Sarwar R, Ahmad T, Ghaffar R, Khan H, Al-Amri I, Csuk R, Al-Rawahi A

Nanomedicine (Lond). 2019 Nov;14(21):2783-2798.
PMID: 31617445 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid regulates the repair of rat sciatic nerve injury by promoting the proliferation of Schwann cells.
Jiang X, Wang Y, Zhang B, Fei X, Guo X, Jia Y, Yu W

Life Sci. 2020 Aug;254():116887.
PMID: 31606377 [PubMed - indexed for MEDLINE]


The Effects of Frankincense Essential Oil on Stress in Rats.
Okano S, Honda Y, Kodama T, Kimura M

J Oleo Sci. 2019;68(10):1003-1009.
PMID: 31582666 [PubMed - indexed for MEDLINE]


A bioinspired 3D shape olibanum-collagen-gelatin scaffolds with tunable porous microstructure for efficient neural tissue regeneration.
Ghorbani F, Zamanian A, Kermanian F, Shamoosi A

Biotechnol Prog. 2020 Jan;36(1):e2918.
PMID: 31576679 [PubMed - indexed for MEDLINE]


Beta-Boswellic Acid and Ethanolic Extract of Olibanum Regulating the Expression Levels of and Genes.
Jebelli A, Khalaj-Kondori M, Bonyadi M, Hosseinpour Feizi MA, Rahmati-Yamchi M

Iran J Pharm Res. 2019;18(2):877-886.
PMID: 31531070 [PubMed - as supplied by publisher]


Acetyl-11-keto-β-boswellic acid (AKBA) Attenuates Oxidative Stress, Inflammation, Complement Activation and Cell Death in Brain Endothelial Cells Following OGD/Reperfusion.
Ahmad S, Khan SA, Kindelin A, Mohseni T, Bhatia K, Hoda MN, Ducruet AF

Neuromolecular Med. 2019 Dec;21(4):505-516.
PMID: 31515728 [PubMed - indexed for MEDLINE]


Effects of resin extract on motor dysfunction and brain oxidative stress in an experimental model of Parkinson's disease.
Doaee P, Rajaei Z, Roghani M, Alaei H, Kamalinejad M

Avicenna J Phytomed. 2019;9(3):281-290.
PMID: 31143695 [PubMed - as supplied by publisher]


Evidence for the involvement of a GABAergic mechanism in the effectiveness of natural and synthetically modified incensole derivatives in neuropharmacological disorders: A computational and pharmacological approach.
Al-Harrasi A, Khan A, Rehman NU, Al-Shidhani S, Karim N, Khan I, Halim SA, Al-Rawahi A, Hussain J, Csuk R

Phytochemistry. 2019 Jul;163():58-74.
PMID: 31015070 [PubMed - indexed for MEDLINE]


Wound Healing Potential of the Standardized Extract of Boswellia serrata on Experimental Diabetic Foot Ulcer via Inhibition of Inflammatory, Angiogenetic and Apoptotic Markers.
Pengzong Z, Yuanmin L, Xiaoming X, Shang D, Wei X, Zhigang L, Dongzhou D, Wenjing Y, Jianbiao Y, Yang X, Xia L

Planta Med. 2019 May;85(8):657-669.
PMID: 30909313 [PubMed - indexed for MEDLINE]


16S rRNA gene profiling and genome reconstruction reveal community metabolic interactions and prebiotic potential of medicinal herbs used in neurodegenerative disease and as nootropics.
Peterson CT, Sharma V, Iablokov SN, Albayrak L, Khanipov K, Uchitel S, Chopra D, Mills PJ, Fofanov Y, Rodionov DA, Peterson SN

PLoS One. 2019;14(3):e0213869.
PMID: 30889210 [PubMed - indexed for MEDLINE]


A Review of Herbal Therapy in Multiple Sclerosis.
Mojaverrostami S, Bojnordi MN, Ghasemi-Kasman M, Ebrahimzadeh MA, Hamidabadi HG

Adv Pharm Bull. 2018 Nov;8(4):575-590.
PMID: 30607330 [PubMed - as supplied by publisher]


Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.
Bai J, Gao Y, Chen L, Yin Q, Lou F, Wang Z, Xu Z, Zhou H, Li Q, Cai W, Sun Y, Niu L, Wang H, Wei Z, Lu S, Zhou A, Zhang J, Wang H

EBioMedicine. 2019 Jan;39():575-590.
PMID: 30591370 [PubMed - indexed for MEDLINE]


Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells.
Seo EJ, Efferth T, Panossian A

Phytomedicine. 2018 Nov;50():285-299.
PMID: 30466988 [PubMed - indexed for MEDLINE]


Effects of 900-MHz radiation on the hippocampus and cerebellum of adult rats and attenuation of such effects by folic acid and .
Kivrak EG, Altunkaynak BZ, Alkan I, Yurt KK, Kocaman A, Onger ME

J Microsc Ultrastruct. 2017;5(4):216-224.
PMID: 30023257 [PubMed - as supplied by publisher]


Frankincense upregulates the hippocampal calcium/calmodulin kinase II-α during development of the rat brain and improves memory performance.
Beheshti S, Ghorbanpour Skakakomi A, Ghaedi K, Dehestani H

Int J Dev Neurosci. 2018 Oct;69():44-48.
PMID: 29966740 [PubMed - indexed for MEDLINE]


Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells.
El-Magd MA, Khalifa SF, A Alzahrani FA, Badawy AA, El-Shetry ES, Dawood LM, Alruwaili MM, Alrawaili HA, Risha EF, El-Taweel FM, Marei HE

Biomed Pharmacother. 2018 Sep;105():813-823.
PMID: 29913410 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid extracted from promotes Schwann cell proliferation and sciatic nerve function recovery.
Jiang XW, Zhang BQ, Qiao L, Liu L, Wang XW, Yu WH

Neural Regen Res. 2018 Mar;13(3):484-491.
PMID: 29623934 [PubMed - as supplied by publisher]


Sadeghnia HR, Arjmand F, Ghorbani A

Acta Pol Pharm. 2017 May;74(3):911-920.
PMID: 29513961 [PubMed - indexed for MEDLINE]


Boswellic Acid Improves Cognitive Function in a Rat Model Through Its Antioxidant Activity: - Neuroprotective effect of Boswellic acid.
Ebrahimpour S, Fazeli M, Mehri S, Taherianfard M, Hosseinzadeh H

J Pharmacopuncture. 2017 Mar;20(1):10-17.
PMID: 28392957 [PubMed - as supplied by publisher]


Boswellia serrata gum resin aqueous extract upregulatesBDNF but not CREB expression in adult male rat hippocampus.
Khalaj-Kondori M, Sadeghi F, Hosseinpourfeizi MA, Shaikhzadeh-Hesari F, Nakhlband A, Rahmati-Yamchi M

Turk J Med Sci. 2016 Nov;46(5):1573-1578.
PMID: 27966331 [PubMed - indexed for MEDLINE]


Combined Administration of and Extracts in an Animal Model of Memory.
Mahboubi M, Taghizadeh M, Talaei SA, Takht Firozeh SM, Rashidi AA, Tamtaji OR

Iran J Psychiatry Behav Sci. 2016 Sep;10(3):e681.
PMID: 27822272 [PubMed - as supplied by publisher]


Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves.
Kohoude MJ, Gbaguidi F, Agbani P, Ayedoun MA, Cazaux S, Bouajila J

Pharm Biol. 2017 Dec;55(1):33-42.
PMID: 27650786 [PubMed - indexed for MEDLINE]


The Effects of Alpha Boswellic Acid on Reelin Expression and Tau Phosphorylation in Human Astrocytes.
Fathi E, Katouli FH, Riazi GH, Shasaltaneh MD, Parandavar E, Bayati S, Afrasiabi A, Nazari R

Neuromolecular Med. 2017 Mar;19(1):136-146.
PMID: 27567921 [PubMed - indexed for MEDLINE]


Aqueous and Ethanolic Extracts of Boswellia serrata Protect Against Focal Cerebral Ischemia and Reperfusion Injury in Rats.
Forouzanfar F, Hosseinzadeh H, Ebrahimzadeh Bideskan A, Sadeghnia HR

Phytother Res. 2016 Dec;30(12):1954-1967.
PMID: 27515127 [PubMed - indexed for MEDLINE]


Boswellia serrata Protects Against Glutamate-Induced Oxidative Stress and Apoptosis in PC12 and N2a Cells.
Rajabian A, Boroushaki MT, Hayatdavoudi P, Sadeghnia HR

DNA Cell Biol. 2016 Nov;35(11):666-679.
PMID: 27494534 [PubMed - indexed for MEDLINE]


Beneficial effect of Boswellia serrata gum resin on spatial learning and the dendritic tree of dentate gyrus granule cells in aged rats.
Hosseini-Sharifabad M, Kamali-Ardakani R, Hosseini-Sharifabad A

Avicenna J Phytomed. 2016;6(2):189-97.
PMID: 27222832 [PubMed - as supplied by publisher]


Co-administration of 3-Acetyl-11-Keto-Beta-Boswellic Acid Potentiates the Protective Effect of Celecoxib in Lipopolysaccharide-Induced Cognitive Impairment in Mice: Possible Implication of Anti-inflammatory and Antiglutamatergic Pathways.
Sayed AS, El Sayed NS

J Mol Neurosci. 2016 May;59(1):58-67.
PMID: 26984336 [PubMed - indexed for MEDLINE]


Tongxinluo reduces brain edema and inhibits post-ischemic inflammation after middle cerebral artery occlusion in rats.
Cai M, Yu Z, Wang L, Song X, Zhang J, Zhang Z, Zhang W, Li W, Xiang J, Cai D

J Ethnopharmacol. 2016 Apr;181():136-45.
PMID: 26805468 [PubMed - indexed for MEDLINE]


Enhanced Neuroprotection of Acetyl-11-Keto-β-Boswellic Acid (AKBA)-Loaded O-Carboxymethyl Chitosan Nanoparticles Through Antioxidant and Anti-Inflammatory Pathways.
Ding Y, Qiao Y, Wang M, Zhang H, Li L, Zhang Y, Ge J, Song Y, Li Y, Wen A

Mol Neurobiol. 2016 Aug;53(6):3842-3853.
PMID: 26162321 [PubMed - indexed for MEDLINE]


The effects of aqueous extract of Boswellia Serrata on hippocampal region CA1 and learning deficit in kindled rats.
Jalili C, Salahshoor MR, Pourmotabbed A, Moradi S, Roshankhah Sh, Darehdori AS, Motaghi M

Res Pharm Sci. 2014;9(5):351-8.
PMID: 25657807 [PubMed - as supplied by publisher]


Posttreatment with 11-Keto-β-Boswellic Acid Ameliorates Cerebral Ischemia-Reperfusion Injury: Nrf2/HO-1 Pathway as a Potential Mechanism.
Ding Y, Chen M, Wang M, Li Y, Wen A

Mol Neurobiol. 2015 Dec;52(3):1430-1439.
PMID: 25452227 [PubMed - indexed for MEDLINE]


Neuroprotection by acetyl-11-keto-β-Boswellic acid, in ischemic brain injury involves the Nrf2/HO-1 defense pathway.
Ding Y, Chen M, Wang M, Wang M, Zhang T, Park J, Zhu Y, Guo C, Jia Y, Li Y, Wen A

Sci Rep. 2014 Nov;4():7002.
PMID: 25384416 [PubMed - indexed for MEDLINE]


Analgesic effects of crude extracts and fractions of Omani frankincense obtained from traditional medicinal plant Boswellia sacra on animal models.
Al-Harrasi A, Ali L, Hussain J, Rehman NU, Mehjabeen , Ahmed M, Al-Rawahi A

Asian Pac J Trop Med. 2014 Sep;7S1():S485-90.
PMID: 25312172 [PubMed - as supplied by publisher]


Identification of dehydroabietc acid from Boswellia thurifera resin as a positive GABAA receptor modulator.
Rueda DC, Raith M, De Mieri M, Schöffmann A, Hering S, Hamburger M

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The therapeutic effect of the aqueous extract of boswellia serrata on the learning deficit in kindled rats.
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Effect of Boswellia serrata gum resin on the morphology of hippocampal CA1 pyramidal cells in aged rat.
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An in vitro study of the role of β-boswellic acid in the microtubule assembly dynamics.
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Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression of submissive animals.
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J Psychopharmacol. 2012 Dec;26(12):1584-93.
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The synergistic effect of beta-boswellic acid and Nurr1 overexpression on dopaminergic programming of antioxidant glutathione peroxidase-1-expressing murine embryonic stem cells.
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The effects of olibanum administered to methimazole-treated dams during lactation on learning and memory of offspring rats.
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Evaluation of systemic administration of Boswellia papyrifera extracts on spatial memory retention in male rats.
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Anticholinesterase activity of endemic plant extracts from Soqotra.
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The beneficial effects of olibanum on memory deficit induced by hypothyroidism in adult rats tested in Morris water maze.
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Arch Pharm Res. 2010 Mar;33(3):463-8.
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The enhancement effect of beta-boswellic acid on hippocampal neurites outgrowth and branching (an in vitro study).
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Neurol Sci. 2010 Jun;31(3):315-20.
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Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain.
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Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii.
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Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice.
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Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid.
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Indian J Exp Biol. 2006 Feb;44(2):128-32.
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Protective effects of nimesulide (COX Inhibitor), AKBA (5-LOX Inhibitor), and their combination in aging-associated abnormalities in mice.
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Analgesic and psychopharmacological effects of the gum resin of Boswellia serrata.
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Analgesic effect of the gum resin of Boswellia serata Roxb.
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Life Sci. 1969 Oct;8(19):1023-8.
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