8.2.1 Nervensystem



3-Acetyl-11-keto-β-boswellic acid attenuated oxidative glutamate toxicity in neuron-like cell lines by apoptosis inhibition.
Rajabian A, Sadeghnia HR, Hosseini A, Mousavi SH, Boroushaki MT

J Cell Biochem. 2019 Oct;():.
PMID: 31642100 [PubMed - as supplied by publisher]


Loading AKBA on surface of silver nanoparticles to improve their sedative-hypnotic and anti-inflammatory efficacies.
Khan A, Al-Harrasi A, Rehman NU, Sarwar R, Ahmad T, Ghaffar R, Khan H, Al-Amri I, Csuk R, Al-Rawahi A

Nanomedicine (Lond). 2019 Nov;14(21):2783-2798.
PMID: 31617445 [PubMed - as supplied by publisher]


Acetyl-11-keto-β-boswellic acid regulates the repair of rat sciatic nerve injury by promoting the proliferation of Schwann cells.
Jiang X, Wang Y, Zhang B, Fei X, Gou X, Jia Y, Yu W

Life Sci. 2019 Oct;():116887.
PMID: 31606377 [PubMed - as supplied by publisher]


The Effects of Frankincense Essential Oil on Stress in Rats.
Okano S, Honda Y, Kodama T, Kimura M

J Oleo Sci. 2019;68(10):1003-1009.
PMID: 31582666 [PubMed - as supplied by publisher]


Beta-Boswellic Acid and Ethanolic Extract of Olibanum Regulating the Expression Levels of and Genes.
Jebelli A, Khalaj-Kondori M, Bonyadi M, Hosseinpour Feizi MA, Rahmati-Yamchi M

Iran J Pharm Res. 2019;18(2):877-886.
PMID: 31531070 [PubMed - as supplied by publisher]


Acetyl-11-keto-β-boswellic acid (AKBA) Attenuates Oxidative Stress, Inflammation, Complement Activation and Cell Death in Brain Endothelial Cells Following OGD/Reperfusion.
Ahmad S, Khan SA, Kindelin A, Mohseni T, Bhatia K, Hoda MN, Ducruet AF

Neuromolecular Med. 2019 Dec;21(4):505-516.
PMID: 31515728 [PubMed - as supplied by publisher]


Effects of resin extract on motor dysfunction and brain oxidative stress in an experimental model of Parkinson's disease.
Doaee P, Rajaei Z, Roghani M, Alaei H, Kamalinejad M

Avicenna J Phytomed. 2019 May-Jun;9(3):281-290.
PMID: 31143695 [PubMed - as supplied by publisher]


Evidence for the involvement of a GABAergic mechanism in the effectiveness of natural and synthetically modified incensole derivatives in neuropharmacological disorders: A computational and pharmacological approach.
Al-Harrasi A, Khan A, Rehman NU, Al-Shidhani S, Karim N, Khan I, Halim SA, Al-Rawahi A, Hussain J, Csuk R

Phytochemistry. 2019 Jul;163():58-74.
PMID: 31015070 [PubMed - indexed for MEDLINE]


Wound Healing Potential of the Standardized Extract of Boswellia serrata on Experimental Diabetic Foot Ulcer via Inhibition of Inflammatory, Angiogenetic and Apoptotic Markers.
Pengzong Z, Yuanmin L, Xiaoming X, Shang D, Wei X, Zhigang L, Dongzhou D, Wenjing Y, Jianbiao Y, Yang X, Xia L

Planta Med. 2019 May;85(8):657-669.
PMID: 30909313 [PubMed - indexed for MEDLINE]


16S rRNA gene profiling and genome reconstruction reveal community metabolic interactions and prebiotic potential of medicinal herbs used in neurodegenerative disease and as nootropics.
Peterson CT, Sharma V, Iablokov SN, Albayrak L, Khanipov K, Uchitel S, Chopra D, Mills PJ, Fofanov Y, Rodionov DA, Peterson SN

PLoS One. 2019;14(3):e0213869.
PMID: 30889210 [PubMed - as supplied by publisher]


A Review of Herbal Therapy in Multiple Sclerosis.
Mojaverrostami S, Bojnordi MN, Ghasemi-Kasman M, Ebrahimzadeh MA, Hamidabadi HG

Adv Pharm Bull. 2018 Nov;8(4):575-590.
PMID: 30607330 [PubMed - as supplied by publisher]


Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.
Bai J, Gao Y, Chen L, Yin Q, Lou F, Wang Z, Xu Z, Zhou H, Li Q, Cai W, Sun Y, Niu L, Wang H, Wei Z, Lu S, Zhou A, Zhang J, Wang H

EBioMedicine. 2019 Jan;39():575-590.
PMID: 30591370 [PubMed - indexed for MEDLINE]


Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells.
Seo EJ, Efferth T, Panossian A

Phytomedicine. 2018 Nov;50():285-299.
PMID: 30466988 [PubMed - indexed for MEDLINE]


Effects of 900-MHz radiation on the hippocampus and cerebellum of adult rats and attenuation of such effects by folic acid and .
Kivrak EG, Altunkaynak BZ, Alkan I, Yurt KK, Kocaman A, Onger ME

J Microsc Ultrastruct. 2017 Oct-Dec;5(4):216-224.
PMID: 30023257 [PubMed - as supplied by publisher]


Frankincense upregulates the hippocampal calcium/calmodulin kinase II-α during development of the rat brain and improves memory performance.
Beheshti S, Ghorbanpour Skakakomi A, Ghaedi K, Dehestani H

Int J Dev Neurosci. 2018 Oct;69():44-48.
PMID: 29966740 [PubMed - indexed for MEDLINE]


Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells.
El-Magd MA, Khalifa SF, A Alzahrani FA, Badawy AA, El-Shetry ES, Dawood LM, Alruwaili MM, Alrawaili HA, Risha EF, El-Taweel FM, Marei HE

Biomed Pharmacother. 2018 Sep;105():813-823.
PMID: 29913410 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid extracted from promotes Schwann cell proliferation and sciatic nerve function recovery.
Jiang XW, Zhang BQ, Qiao L, Liu L, Wang XW, Yu WH

Neural Regen Res. 2018 Mar;13(3):484-491.
PMID: 29623934 [PubMed - as supplied by publisher]


Sadeghnia HR, Arjmand F, Ghorbani A

Acta Pol Pharm. 2017 May;74(3):911-920.
PMID: 29513961 [PubMed - indexed for MEDLINE]


Boswellic Acid Improves Cognitive Function in a Rat Model Through Its Antioxidant Activity: - Neuroprotective effect of Boswellic acid.
Ebrahimpour S, Fazeli M, Mehri S, Taherianfard M, Hosseinzadeh H

J Pharmacopuncture. 2017 Mar;20(1):10-17.
PMID: 28392957 [PubMed - as supplied by publisher]


Boswellia serrata gum resin aqueous extract upregulatesBDNF but not CREB expression in adult male rat hippocampus.
Khalaj-Kondori M, Sadeghi F, Hosseinpourfeizi MA, Shaikhzadeh-Hesari F, Nakhlband A, Rahmati-Yamchi M

Turk J Med Sci. 2016 Nov;46(5):1573-1578.
PMID: 27966331 [PubMed - indexed for MEDLINE]


Combined Administration of and Extracts in an Animal Model of Memory.
Mahboubi M, Taghizadeh M, Talaei SA, Takht Firozeh SM, Rashidi AA, Tamtaji OR

Iran J Psychiatry Behav Sci. 2016 Sep;10(3):e681.
PMID: 27822272 [PubMed - as supplied by publisher]


Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves.
Kohoude MJ, Gbaguidi F, Agbani P, Ayedoun MA, Cazaux S, Bouajila J

Pharm Biol. 2017 Dec;55(1):33-42.
PMID: 27650786 [PubMed - indexed for MEDLINE]


The Effects of Alpha Boswellic Acid on Reelin Expression and Tau Phosphorylation in Human Astrocytes.
Fathi E, Katouli FH, Riazi GH, Shasaltaneh MD, Parandavar E, Bayati S, Afrasiabi A, Nazari R

Neuromolecular Med. 2017 Mar;19(1):136-146.
PMID: 27567921 [PubMed - indexed for MEDLINE]


Aqueous and Ethanolic Extracts of Boswellia serrata Protect Against Focal Cerebral Ischemia and Reperfusion Injury in Rats.
Forouzanfar F, Hosseinzadeh H, Ebrahimzadeh Bideskan A, Sadeghnia HR

Phytother Res. 2016 Dec;30(12):1954-1967.
PMID: 27515127 [PubMed - indexed for MEDLINE]


Boswellia serrata Protects Against Glutamate-Induced Oxidative Stress and Apoptosis in PC12 and N2a Cells.
Rajabian A, Boroushaki MT, Hayatdavoudi P, Sadeghnia HR

DNA Cell Biol. 2016 Nov;35(11):666-679.
PMID: 27494534 [PubMed - indexed for MEDLINE]


Beneficial effect of Boswellia serrata gum resin on spatial learning and the dendritic tree of dentate gyrus granule cells in aged rats.
Hosseini-Sharifabad M, Kamali-Ardakani R, Hosseini-Sharifabad A

Avicenna J Phytomed. 2016 Mar-Apr;6(2):189-97.
PMID: 27222832 [PubMed - as supplied by publisher]


Co-administration of 3-Acetyl-11-Keto-Beta-Boswellic Acid Potentiates the Protective Effect of Celecoxib in Lipopolysaccharide-Induced Cognitive Impairment in Mice: Possible Implication of Anti-inflammatory and Antiglutamatergic Pathways.
Sayed AS, El Sayed NS

J Mol Neurosci. 2016 May;59(1):58-67.
PMID: 26984336 [PubMed - indexed for MEDLINE]


Tongxinluo reduces brain edema and inhibits post-ischemic inflammation after middle cerebral artery occlusion in rats.
Cai M, Yu Z, Wang L, Song X, Zhang J, Zhang Z, Zhang W, Li W, Xiang J, Cai D

J Ethnopharmacol. 2016 Apr;181():136-45.
PMID: 26805468 [PubMed - indexed for MEDLINE]


Enhanced Neuroprotection of Acetyl-11-Keto-β-Boswellic Acid (AKBA)-Loaded O-Carboxymethyl Chitosan Nanoparticles Through Antioxidant and Anti-Inflammatory Pathways.
Ding Y, Qiao Y, Wang M, Zhang H, Li L, Zhang Y, Ge J, Song Y, Li Y, Wen A

Mol Neurobiol. 2016 08;53(6):3842-3853.
PMID: 26162321 [PubMed - indexed for MEDLINE]


The effects of aqueous extract of Boswellia Serrata on hippocampal region CA1 and learning deficit in kindled rats.
Jalili C, Salahshoor MR, Pourmotabbed A, Moradi S, Roshankhah Sh, Darehdori AS, Motaghi M

Res Pharm Sci. 2014 Sep-Oct;9(5):351-8.
PMID: 25657807 [PubMed - as supplied by publisher]


Posttreatment with 11-Keto-β-Boswellic Acid Ameliorates Cerebral Ischemia-Reperfusion Injury: Nrf2/HO-1 Pathway as a Potential Mechanism.
Ding Y, Chen M, Wang M, Li Y, Wen A

Mol Neurobiol. 2015 Dec;52(3):1430-1439.
PMID: 25452227 [PubMed - indexed for MEDLINE]


Neuroprotection by acetyl-11-keto-β-Boswellic acid, in ischemic brain injury involves the Nrf2/HO-1 defense pathway.
Ding Y, Chen M, Wang M, Wang M, Zhang T, Park J, Zhu Y, Guo C, Jia Y, Li Y, Wen A

Sci Rep. 2014 Nov;4():7002.
PMID: 25384416 [PubMed - indexed for MEDLINE]


Analgesic effects of crude extracts and fractions of Omani frankincense obtained from traditional medicinal plant Boswellia sacra on animal models.
Al-Harrasi A, Ali L, Hussain J, Rehman NU, Mehjabeen , Ahmed M, Al-Rawahi A

Asian Pac J Trop Med. 2014 Sep;7S1():S485-90.
PMID: 25312172 [PubMed - as supplied by publisher]


Identification of dehydroabietc acid from Boswellia thurifera resin as a positive GABAA receptor modulator.
Rueda DC, Raith M, De Mieri M, Schöffmann A, Hering S, Hamburger M

Fitoterapia. 2014 Dec;99():28-34.
PMID: 25200370 [PubMed - indexed for MEDLINE]


The therapeutic effect of the aqueous extract of boswellia serrata on the learning deficit in kindled rats.
Jalili C, Salahshoor MR, Moradi S, Pourmotabbed A, Motaghi M

Int J Prev Med. 2014 May;5(5):563-8.
PMID: 24932387 [PubMed - as supplied by publisher]


Effect of Boswellia serrata gum resin on the morphology of hippocampal CA1 pyramidal cells in aged rat.
Hosseini-sharifabad M, Esfandiari E

Anat Sci Int. 2015 Jan;90(1):47-53.
PMID: 24515442 [PubMed - indexed for MEDLINE]


An in vitro study of the role of β-boswellic acid in the microtubule assembly dynamics.
Karima O, Riazi G, Khodadadi S, Yousefi R, Mahnam K, Mokhtari F, Cheraghi T, Hoveizi E, Moosavi-Movahedi AA

FEBS Lett. 2012 Nov;586(23):4132-8.
PMID: 23098754 [PubMed - indexed for MEDLINE]


Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression of submissive animals.
Moussaieff A, Gross M, Nesher E, Tikhonov T, Yadid G, Pinhasov A

J Psychopharmacol. 2012 Dec;26(12):1584-93.
PMID: 23015543 [PubMed - indexed for MEDLINE]


The synergistic effect of beta-boswellic acid and Nurr1 overexpression on dopaminergic programming of antioxidant glutathione peroxidase-1-expressing murine embryonic stem cells.
Abasi M, Massumi M, Riazi G, Amini H

Neuroscience. 2012 Oct;222():404-16.
PMID: 22800564 [PubMed - indexed for MEDLINE]


Protective effects of incensole acetate on cerebral ischemic injury.
Moussaieff A, Yu J, Zhu H, Gattoni-Celli S, Shohami E, Kindy MS

Brain Res. 2012 Mar;1443():89-97.
PMID: 22284622 [PubMed - indexed for MEDLINE]


The effects of olibanum administered to methimazole-treated dams during lactation on learning and memory of offspring rats.
Hosseini M, Shafei MN, Safari V, Taiarani Z, Kafami Ladani M, Sadeghian R

Nat Prod Res. 2012;26(16):1544-8.
PMID: 22007658 [PubMed - indexed for MEDLINE]


Evaluation of systemic administration of Boswellia papyrifera extracts on spatial memory retention in male rats.
Mahmoudi A, Hosseini-Sharifabad A, Monsef-Esfahani HR, Yazdinejad AR, Khanavi M, Roghani A, Beyer C, Sharifzadeh M

J Nat Med. 2011 Jul;65(3-4):519-25.
PMID: 21479965 [PubMed - indexed for MEDLINE]


Anticholinesterase activity of endemic plant extracts from Soqotra.
Bakthira H, Awadh Ali NA, Arnold N, Teichert A, Wessjohann L

Afr J Tradit Complement Altern Med. 2011;8(3):296-9.
PMID: 22468008 [PubMed - indexed for MEDLINE]


The beneficial effects of olibanum on memory deficit induced by hypothyroidism in adult rats tested in Morris water maze.
Hosseini M, Hadjzadeh MA, Derakhshan M, Havakhah S, Rassouli FB, Rakhshandeh H, Saffarzadeh F

Arch Pharm Res. 2010 Mar;33(3):463-8.
PMID: 20361313 [PubMed - indexed for MEDLINE]


The enhancement effect of beta-boswellic acid on hippocampal neurites outgrowth and branching (an in vitro study).
Karima O, Riazi G, Yousefi R, Movahedi AA

Neurol Sci. 2010 Jun;31(3):315-20.
PMID: 20217445 [PubMed - indexed for MEDLINE]


Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain.
Moussaieff A, Rimmerman N, Bregman T, Straiker A, Felder CC, Shoham S, Kashman Y, Huang SM, Lee H, Shohami E, Mackie K, Caterina MJ, Walker JM, Fride E, Mechoulam R

FASEB J. 2008 Aug;22(8):3024-34.
PMID: 18492727 [PubMed - indexed for MEDLINE]


Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii.
Moussaieff A, Shein NA, Tsenter J, Grigoriadis S, Simeonidou C, Alexandrovich AG, Trembovler V, Ben-Neriah Y, Schmitz ML, Fiebich BL, Munoz E, Mechoulam R, Shohami E

J Cereb Blood Flow Metab. 2008 Jul;28(7):1341-52.
PMID: 18414499 [PubMed - indexed for MEDLINE]


Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice.
Bishnoi M, Patil CS, Kumar A, Kulkarni SK

Pharmacology. 2007;79(1):34-41.
PMID: 17139192 [PubMed - indexed for MEDLINE]


Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid.
Bishnoi M, Patil CS, Kumar A, Kulkarni SK

Indian J Exp Biol. 2006 Feb;44(2):128-32.
PMID: 16480179 [PubMed - indexed for MEDLINE]


Protective effects of nimesulide (COX Inhibitor), AKBA (5-LOX Inhibitor), and their combination in aging-associated abnormalities in mice.
Bishnoi M, Patil CS, Kumar A, Kulkarni SK

Methods Find Exp Clin Pharmacol. 2005 Sep;27(7):465-70.
PMID: 16258590 [PubMed - indexed for MEDLINE]


Analgesic and psychopharmacological effects of the gum resin of Boswellia serrata.
Menon MK, Kar A

Planta Med. 1971 Apr;19(4):333-41.
PMID: 5573545 [PubMed - indexed for MEDLINE]


Analgesic effect of the gum resin of Boswellia serata Roxb.
Kar A, Menon MK

Life Sci. 1969 Oct;8(19):1023-8.
PMID: 5351016 [PubMed - indexed for MEDLINE]