8.1.3 Nervous System



Acetyl-11-keto-beta-boswellic acid modulates macrophage polarization and Schwann cell migration to accelerate spinal cord injury repair in rats.
Wang Y, Xiong Z, Qiao Y, Zhang Q, Zhou G, Zhou C, Ma X, Jiang X, Yu W

CNS Neurosci Ther. 2024 Mar;30(3):e14642.
PMID: 38430464 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid improves clinical symptoms through modulation of Nrf2 and NF-κB pathways in SJL/J mouse model of experimental autoimmune encephalomyelitis.
Nadeem A, Ahmad SF, Al-Harbi NO, Sarawi W, Attia SM, Alanazi WA, Ibrahim KE, Alsanea S, Alqarni SA, Alfardan AS, Bakheet SA

Int Immunopharmacol. 2022 Jun;107():108703.
PMID: 35306283 [PubMed - indexed for MEDLINE]


The Biological Activity of 3-O-Acetyl-11-keto-β-Boswellic Acid in Nervous System Diseases.
Gong Y, Jiang X, Yang S, Huang Y, Hong J, Ma Y, Fang X, Fang Y, Wu J

Neuromolecular Med. 2022 Dec;24(4):374-384.
PMID: 35303275 [PubMed - indexed for MEDLINE]


The Effects of Incensole Acetate on Neuro-inflammation, Brain-Derived Neurotrophic Factor and Memory Impairment Induced by Lipopolysaccharide in Rats.
Marefati N, Beheshti F, Vafaee F, Barabadi M, Hosseini M

Neurochem Res. 2021 Sep;46(9):2473-2484.
PMID: 34173963 [PubMed - indexed for MEDLINE]


The effects of pre-treatment with olibanum and its constituent, boswellic acid on synaptic plasticity impairments induced by lipopolysaccharide in rats.
Marefati N, Beheshti F, Memarpour S, Rezaei M, Hosseini M

Avicenna J Phytomed. 2021;11(1):68-78.
PMID: 33628721 [PubMed - as supplied by publisher]


The effects of acetyl-11-keto-β-boswellic acid on brain cytokines and memory impairment induced by lipopolysaccharide in rats.
Marefati N, Beheshti F, Memarpour S, Bayat R, Naser Shafei M, Sadeghnia HR, Ghazavi H, Hosseini M

Cytokine. 2020 Jul;131():155107.
PMID: 32380425 [PubMed - indexed for MEDLINE]


Protective Effect and Mechanism of Boswellic Acid and Myrrha Sesquiterpenes with Different Proportions of Compatibility on Neuroinflammation by LPS-Induced BV2 Cells Combined with Network Pharmacology.
Miao XD, Zheng LJ, Zhao ZZ, Su SL, Zhu Y, Guo JM, Shang EX, Qian DW, Duan JA

Molecules. 2019 Oct;24(21):.
PMID: 31683684 [PubMed - indexed for MEDLINE]


Acetyl-11-keto-β-boswellic acid (AKBA) Attenuates Oxidative Stress, Inflammation, Complement Activation and Cell Death in Brain Endothelial Cells Following OGD/Reperfusion.
Ahmad S, Khan SA, Kindelin A, Mohseni T, Bhatia K, Hoda MN, Ducruet AF

Neuromolecular Med. 2019 Dec;21(4):505-516.
PMID: 31515728 [PubMed - indexed for MEDLINE]


Distribution of the anti-inflammatory and anti-depressant compounds: Incensole and incensole acetate in genus Boswellia.
Al-Harrasi A, Csuk R, Khan A, Hussain J

Phytochemistry. 2019 May;161():28-40.
PMID: 30802641 [PubMed - indexed for MEDLINE]


Role of 3-Acetyl-11-Keto-Beta-Boswellic Acid in Counteracting LPS-Induced Neuroinflammation via Modulation of miRNA-155.
Sayed AS, Gomaa IEO, Bader M, El Sayed NSED

Mol Neurobiol. 2018 Jul;55(7):5798-5808.
PMID: 29079998 [PubMed - indexed for MEDLINE]


Acetyl-lupeolic acid inhibits Akt signaling and induces apoptosis in chemoresistant prostate cancer cells and .
Schmidt C, Loos C, Jin L, Schmiech M, Schmidt CQ, Gaafary ME, Syrovets T, Simmet T

Oncotarget. 2017 Aug;8(33):55147-55161.
PMID: 28903409 [PubMed - as supplied by publisher]


Anti-inflammatory and neuroprotective activity of boswellic acids in rotenone parkinsonian rats.
Ameen AM, Elkazaz AY, Mohammad HMF, Barakat BM

Can J Physiol Pharmacol. 2017 Jul;95(7):819-829.
PMID: 28249117 [PubMed - indexed for MEDLINE]


Co-administration of 3-Acetyl-11-Keto-Beta-Boswellic Acid Potentiates the Protective Effect of Celecoxib in Lipopolysaccharide-Induced Cognitive Impairment in Mice: Possible Implication of Anti-inflammatory and Antiglutamatergic Pathways.
Sayed AS, El Sayed NS

J Mol Neurosci. 2016 May;59(1):58-67.
PMID: 26984336 [PubMed - indexed for MEDLINE]


Tongxinluo reduces brain edema and inhibits post-ischemic inflammation after middle cerebral artery occlusion in rats.
Cai M, Yu Z, Wang L, Song X, Zhang J, Zhang Z, Zhang W, Li W, Xiang J, Cai D

J Ethnopharmacol. 2016 Apr;181():136-45.
PMID: 26805468 [PubMed - indexed for MEDLINE]


Enhanced Neuroprotection of Acetyl-11-Keto-β-Boswellic Acid (AKBA)-Loaded O-Carboxymethyl Chitosan Nanoparticles Through Antioxidant and Anti-Inflammatory Pathways.
Ding Y, Qiao Y, Wang M, Zhang H, Li L, Zhang Y, Ge J, Song Y, Li Y, Wen A

Mol Neurobiol. 2016 Aug;53(6):3842-3853.
PMID: 26162321 [PubMed - indexed for MEDLINE]


Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii.
Moussaieff A, Shein NA, Tsenter J, Grigoriadis S, Simeonidou C, Alexandrovich AG, Trembovler V, Ben-Neriah Y, Schmitz ML, Fiebich BL, Munoz E, Mechoulam R, Shohami E

J Cereb Blood Flow Metab. 2008 Jul;28(7):1341-52.
PMID: 18414499 [PubMed - indexed for MEDLINE]


Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice.
Bishnoi M, Patil CS, Kumar A, Kulkarni SK

Pharmacology. 2007;79(1):34-41.
PMID: 17139192 [PubMed - indexed for MEDLINE]


Dietary support with Boswellia resin in canine inflammatory joint and spinal disease.
Reichling J, Schmökel H, Fitzi J, Bucher S, Saller R

Schweiz Arch Tierheilkd. 2004 Feb;146(2):71-9.
PMID: 14994484 [PubMed - indexed for MEDLINE]


Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis.
Wildfeuer A, Neu IS, Safayhi H, Metzger G, Wehrmann M, Vogel U, Ammon HP

Arzneimittelforschung. 1998 Jun;48(6):668-74.
PMID: 9689425 [PubMed - indexed for MEDLINE]