8.2.7 Metabolism / Diabetes

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Auszug aus Phytomedicine 18 (2011) 1037-1044
mit Erlaubnis: Elsevier GmbH, Urban & Fischer Verlag München

Prevention of Multiple Low-Dose Streptozotocin (MLD-STZ) diabetes
in mice by an extract from gum resin of Boswellia serrata (BE)

Ahmed M. Shehata (a, c), L. Quintanilla-Fend (b) , Sabrina Bettio (b), H.P.T. Ammon (a)
(a) Department of Pharmacology, Institute of Pharmaceutical Sciences, University of Tuebingen, Germany
(b) Institute of Pathology, University of Tuebingen, Germany
(c) Department of Pharmacology, Faculty of Pharmacy, Beni-Sueif University, Egypt

Type 1-diabetes is an autoimmune disease, where a chronic inflammatory process
finally causes β-cell death and insulin deficiency. Extracts from gum resin of Boswellia
serrata (BE) have been shown to posses anti-inflammatory properties especially by
targeting factors/mediators related to autoimmune diseases. Multiple Low Dose-
Streptozotocin (MLD-STZ) treatment is a method to induce diabetes in animals similar
to Type 1 diabetes in humans.
It was aimed to study whether or not a BE could prevent hyperglycemia, inflammation of
pancreatic islets and increase of proinflammatory cytokines in the blood in MLD-STZ
treated mice.
In BK+/+ wild type mice, 5 days of daily treatment with 40 mg/kg STZ i.p. produced
permanent increase of blood glucose, infiltration of lymphocytes into pancreatic islets
(CD3-stain), apoptosis of periinsular cells (staining for activated caspase 3) after 10
days as well as shrinking of islet tissue after 35 days (H&E staining). This was
associated with an increase of granulocyte colony stimulating factor (G-CSF),
granulocyte/macrophage colony stimulating factor (GM-CSF) and proinflammatory
cytokines (IL-1A, IL-1B, IL-2, IL-6, IFN-γ, TNF-α) in the blood. Whereas BE alone did
not affect blood glucose in non diabetic mice, in STZ treated mice simultaneous i.p.
injection of 150 mg/kg of BE over 10 days prevented animals from increase of blood
glucose levels. Histochemical studies showed, that i.p. injection of 150 mg/kg BE for 10
days starting with STZ treatment, avoided lymphocyte infiltration into islets, apoptosis of
periinsular cells and shrinking of islet size 35 days after STZ. As far as the cytokines
tested are concerned, there was a significant inhibition of the increase of G-CSF and
GM-CSF. BE also significantly prevented the increase of IL-1A, IL-1B, IL-2, IL-6, IFN-γ
and TNF-α. It is concluded that extracts from the gum resin of Boswellia serrata prevent
islet destruction and consequent hyperglycemia in an animal model of type 1 diabetes
probably by inhibition of the production/action of cytokines related to induction of islet
inflammation in an autoimmune process.



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