11.10 Tumores

Wie im experimentellen Teil gezeigt, hemmen gewissen Boswelliasäuren das Wachstum verschiedener Karzinomzellen in vitro durch

  • Hemmung der Zellteilung (Proliferation)
  • Hemmung der für die Zellteilung wichtigen Topoisomerasen
  • Selbsttötung (Apoptose)

Studien, die eine Wirksamkeit eines Weihrauchextraktes oder von Boswelliasäuren beim Menschen beweisen, gibt es derzeit nicht.

Dagegen gibt es einige Studien, die eine Verminderung peritumoraler Hirnödeme nahelegen. Dies könnte etwas mit der ödemproduzierenden Wirkung von Leukotrien zu tun haben, über die manche Tumore verfügen.

Cysteinyl-leukotrienes as potential mediators of the peritumoral brain oedema in astrocytoma patients.
Heldt RM, Winking M, Simmet Th.
Dept. or Pharmacology and Toxicology, Ruhr University, D-44780 Bochum and Dept. of Neurosurgery, Justus-Liebig University, D-35385 Gießen, Germany.
We have previously observed that human malignant astrocytomas or glioblastomas synthesize large amounts of cysteinyl-leukotrienes (LT) both in vitro as well as in vivo. Indeed patients with malignant astrocytomas were found to excrete large amounts of urinary LTE4 as determined by reverse phase HPLC and radioimmunoassay. After neurosurgical tumor removal urinary LTE4 excretion dropped to control levels. In cases with tumor recidives urinary LTE4 excretion increased again. Cysteinyl-LT could possibly contribute to the so-called perifocal brain oedema in such patients. Therefore, by computer-assisted tomography both peritumoral brain oedema as well as the brain tumor volume were determined. Analysis of the urinary LTE4 excretion revealed that a highly significant correlation exists between the urinary LTE4 excretion and the perifocal brain oedema volume. Treament of such patients with dexamethasone 4×4 mg/d over a 7 day period did not significantly affect neither the peritumoral oedema volume nor the urinary LTE4 excretion. It has recently been reported that boswellic acids contained in extracts from boswellia serrata are nonredox inhibitors of the 5-lipoxygenase pathway (J Pharmacol Exp Ther 261:143, 1992). In a preliminary study we have tested the effects of such an extract, H15, available on the swiss market on urinary LTE4 excretion, on ex vivo cysteinyl-LT formation in ionophore A23187-stimulated whole blood and on perifocal brain oedema as assessed by CCT scans. Patients were treated with 3×3 tablets (400 mg/tablet) over 7 days. The parameters mentioned were determined before and after 7 days of treatment. The treatment regimen led to a significant decrease in all parameters, i.e. urinary LTE4 excretion, ex vivo cysteinly-LT formation as well as perifocal brain oedema volume. These results support the hypothesis that cysteinyl-LT might play a role in the pathogenesis of the peritumoral brain oedema in astrocytome or glioblastoma patients.
Archives of Pharmacology. Supplement to Volume 353 No.4 (1996) P 142

oedem.jpg

Die Rolle von Boswellia-Säuren in der Therapie maligner Gliome.
Böker DK, Winking M.
RESÜMEE: Boswellia-Säuren vermögen offenbar über eine Hemmung der Leukotrienensynthese durch Gliomzellen die Ausprägung des perifokalen Ödems günstig zu beeinflussen. Unsere Studie zeigt eine eindeutige Dosis/Wirkungsbeziehung. Aufgrund dieser Studie kann allerdings keine Aussage darüber gemacht werden, ob mit längerer Therapiedauer ein Nachlassen der Wirksamkeit eintritt. Während der nur siebentägigen Therapie hat sich ein belegbarer Effekt von Boswellia-Säuren auf die Tumorgröße im Sinne einer Tumorreduktion nicht nachweisen lassen. Allerdings hat sich in vitro an Gliomzell-Linien, die mit Boswellia-Säuresubtypen in Reinsubstanz inkubiert wurden, eine konzentrationsabhängige Abnahme vitaler Tumorzellen zeigen lassen. Hieraus könnte neben der antiödematösen Wirkung auch eine gliomzell-proliferationshemmende Wirkung abgeleitet werden. Dieser Schluß ist jedoch bei dem derzeitigen Stand der Kenntnisse verfrüht.
Deutsches Ärzteblatt 94, B 958 – B 960, 1997

Publications

1.

Frankincense Essential Oil as a Supportive Therapy for Cancer-Related Fatigue: A Case Study.

Holist Nurs Pract. 2018 May/Jun;32(3):140-142.
PMID: 29642127 [PubMed - indexed for MEDLINE]

2.

A Pilot Study to Examine the Effects of an Anti-inflammatory Supplement on Eicosanoid Derivatives in Patients with Chronic Kidney Disease.

J Altern Complement Med. 2017 Aug;23(8):632-638.
PMID: 28375641 [PubMed - indexed for MEDLINE]

3.

Cancer Chemopreventive Effects of Boswellia sacra Gum Resin Hydrodistillates on Invasive Urothelial Cell Carcinoma: Report of a Case.

Integr Cancer Ther. 2017 12;16(4):605-611.
PMID: 27531547 [PubMed - indexed for MEDLINE]

4.

A randomized trial of Boswellia in association with betaine and myo-inositol in the management of breast fibroadenomas.

Eur Rev Med Pharmacol Sci. 2016 05;20(9):1860-5.
PMID: 27212181 [PubMed - indexed for MEDLINE]

5.

A Randomized Pilot Study of Inositol in Association with Betaine and Boswellia in the Management of Mastalgia and Benign Breast Lump in Premenopausal Women.

Breast Cancer (Auckl). 2016;10():37-43.
PMID: 27127407 [PubMed - as supplied by publisher]

6.

An association of boswellia, betaine and myo-inositol (Eumastós) in the treatment of mammographic breast density: a randomized, double-blind study.

Eur Rev Med Pharmacol Sci. 2015 Nov;19(22):4419-26.
PMID: 26636532 [PubMed - indexed for MEDLINE]

7.

Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial.

Eur Rev Med Pharmacol Sci. 2015 Apr;19(8):1338-44.
PMID: 25967706 [PubMed - indexed for MEDLINE]

8.

The use of aromasticks at a cancer centre: a retrospective audit.

Complement Ther Clin Pract. 2014 Nov;20(4):203-6.
PMID: 25486854 [PubMed - indexed for MEDLINE]

9.

A case of metastatic bladder cancer in both lungs treated with korean medicine therapy alone.

Case Rep Oncol. 2014 May;7(2):534-40.
PMID: 25232323 [PubMed - as supplied by publisher]

10.

The use of an anti-inflammatory supplement in patients with chronic kidney disease.

J Complement Integr Med. 2013 Jul;10():.
PMID: 23828329 [PubMed - indexed for MEDLINE]

11.

Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial.

Cancer. 2011 Aug;117(16):3788-95.
PMID: 21287538 [PubMed - indexed for MEDLINE]

12.

Temporary anti-cancer & anti-pain effects of mechanical stimulation of any one of 3 front teeth (1st incisor, 2nd incisor, & canine) of right & left side of upper & lower jaws and their possible mechanism, & relatively long term disappearance of pain & cancer parameters by one optimal dose of DHEA, Astragalus, Boswellia Serrata, often with press needle stimulation of True ST. 36.

Acupunct Electrother Res. 2009;34(3-4):175-203.
PMID: 20344885 [PubMed - indexed for MEDLINE]

13.

[Effects of aroma hand massage on pain, state anxiety and depression in hospice patients with terminal cancer].

Taehan Kanho Hakhoe Chi. 2008 Aug;38(4):493-502.
PMID: 18753801 [PubMed - indexed for MEDLINE]

14.

A lipoxygenase inhibitor in breast cancer brain metastases.

J Neurooncol. 2007 Mar;82(1):91-3.
PMID: 17001517 [PubMed - indexed for MEDLINE]

15.

Response of radiochemotherapy-associated cerebral edema to a phytotherapeutic agent, H15.

Neurology. 2001 May;56(9):1219-21.
PMID: 11342692 [PubMed - indexed for MEDLINE]

16.

Boswellic acids in the palliative therapy of children with progressive or relapsed brain tumors.

Klin Padiatr. 2000 Jul-Aug;212(4):189-95.
PMID: 10994549 [PubMed - indexed for MEDLINE]